Understanding Dopaminergic Cell Death Pathways in Parkinson Disease: Cell Death in Parkinson Disease

Abstract : Parkinson’s disease (PD) is a multifactorial neurodegenerative disorder, the etiology of which remains largely unknown. Progressive impairment of voluntary motor control, which represents the primary clinical feature of the disease, is caused by a loss of midbrain substantia nigra dopamine (DA) neurons. We present, here, a synthetic overview of cell autonomous mechanisms that are likely to participate in DA cell death in both sporadic and inherited forms of the disease. In particular, we describe how damage to vulnerable DA neurons may arise from cellular disturbances produced by protein misfolding and aggregation, disruption of autophagic catabolism, endoplasmic reticulum (ER) stress, mitochondrial dysfunction or loss of calcium homeostasis. Where pertinent, we show how these mechanisms may mutually cooperate to promote neuronal death.
Type de document :
Article dans une revue
Neuron, Elsevier, 2016, 90 ((4)), pp.675-91. 〈10.1016/j.neuron.2016.03.038〉
Liste complète des métadonnées

Littérature citée [62 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01348875
Contributeur : Etienne Hirsch <>
Soumis le : mardi 26 juillet 2016 - 09:30:41
Dernière modification le : vendredi 31 août 2018 - 09:03:57
Document(s) archivé(s) le : jeudi 27 octobre 2016 - 10:40:11

Fichier

HirschRevised30March2016Hal.pd...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

UPMC | ICM

Citation

Patrick P. Michel, Etienne Hirsch, Stéphane Hunot. Understanding Dopaminergic Cell Death Pathways in Parkinson Disease: Cell Death in Parkinson Disease. Neuron, Elsevier, 2016, 90 ((4)), pp.675-91. 〈10.1016/j.neuron.2016.03.038〉. 〈inserm-01348875〉

Partager

Métriques

Consultations de la notice

189

Téléchargements de fichiers

352