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Reply to Pattou et al. GASTRO-D-16-00421

Abstract : We thank Pattou, Daoudi and Baud for their interest in our work 1 , as well as for their complementary work 2 , on intestinal absorption of ingested glucose after Roux-en-Y Gastric Bypass (RYGB). Based on their recent data obtained with a minipig model of RYGB, they claim this bariatric surgery to affect postprandial glucose metabolism primarily by modulating sodium-glucose intestinal cotransport. They further propose this hypothesis as an " alternative explanation " of our previous data obtained in a rat model and in human subjects who underwent RYGB surgery. First of all, and contrary to what is stated in the above Letter, we never concluded in Cavin et al. 1 that " RYGB does not modify the uptake of ingested glucose ". Our ex vivo studies on intestinal transport revealed that greater amounts of ingested glucose remain within the Roux limb mucosa, as shown by increased luminal glucose uptake and increased SGLT-1 activity when compared to sham rats 1. In vivo, such a retention may result in a reduced transfer of ingested glucose to the blood.
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Submitted on : Tuesday, July 19, 2016 - 12:29:17 PM
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Maude Le Gall, André Bado, Jean-Baptiste Cavin. Reply to Pattou et al. GASTRO-D-16-00421. Gastroenterology, Elsevier, 2016, ⟨10.1053/j.gastro.2016.05.043⟩. ⟨inserm-01346607⟩



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