B. Kahn and J. Flier, Obesity and insulin resistance, Journal of Clinical Investigation, vol.106, issue.4, pp.473-481, 2000.
DOI : 10.1172/JCI10842

M. Herman and B. Kahn, Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony, Journal of Clinical Investigation, vol.116, issue.7, pp.1767-1775, 2006.
DOI : 10.1172/JCI29027

G. Hotamisligil, Inflammation and metabolic disorders, Nature, vol.314, issue.7121, pp.860-867, 2006.
DOI : 10.1038/nature05485

S. Furukawa, T. Fujita, M. Shimabukuro, M. Iwaki, Y. Yamada et al., Increased oxidative stress in obesity and its impact on metabolic syndrome, Journal of Clinical Investigation, vol.114, issue.12, pp.1752-1761, 2004.
DOI : 10.1172/JCI21625DS1

N. Houstis, E. Rosen, and E. Lander, Reactive oxygen species have a causal role in multiple forms of insulin resistance, Nature, vol.18, issue.7086, pp.944-948, 2006.
DOI : 10.1038/nature04634

P. Trayhurn, Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity, Annual Review of Nutrition, vol.34, issue.1, pp.207-236, 2014.
DOI : 10.1146/annurev-nutr-071812-161156

M. Gregor and G. Hotamisligil, Inflammatory Mechanisms in Obesity, Annual Review of Immunology, vol.29, issue.1, pp.415-445, 2011.
DOI : 10.1146/annurev-immunol-031210-101322

N. Bashan, J. Kovsan, I. Kachko, H. Ovadia, and A. Rudich, Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species, Physiological Reviews, vol.89, issue.1, pp.27-71, 2009.
DOI : 10.1152/physrev.00014.2008

J. Tanti and J. Jager, Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation, Current Opinion in Pharmacology, vol.9, issue.6, pp.753-762, 2009.
DOI : 10.1016/j.coph.2009.07.004

C. Regazzetti, P. Peraldi, T. Grémeaux, R. Najem-lendom, I. Ben-sahra et al., Hypoxia Decreases Insulin Signaling Pathways in Adipocytes, Diabetes, vol.58, issue.1, pp.95-103, 2009.
DOI : 10.2337/db08-0457

URL : https://hal.archives-ouvertes.fr/hal-00442082

H. Hafsi and P. Hainaut, Redox Control and Interplay Between p53 Isoforms: Roles in the Regulation of Basal p53 Levels, Cell Fate, and Senescence, Antioxidants & Redox Signaling, vol.15, issue.6, pp.155-1667, 2011.
DOI : 10.1089/ars.2010.3771

P. Hallenborg, S. Feddersen, L. Madsen, and K. Kristiansen, The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function, Expert Opinion on Therapeutic Targets, vol.375, issue.2, pp.235-246, 2009.
DOI : 10.1080/07853890701408194

M. Schupp, F. Chen, E. Briggs, S. Rao, H. Pelzmann et al., Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues, BMC Genomics, vol.14, issue.1, p.758, 2013.
DOI : 10.1093/nar/gkq1289

N. Yahagi, H. Shimano, T. Matsuzaka, Y. Najima, M. Sekiya et al., p53 Activation in Adipocytes of Obese Mice, Journal of Biological Chemistry, vol.278, issue.28, pp.25395-25400, 2003.
DOI : 10.1074/jbc.M302364200

T. Minamino, M. Orimo, I. Shiminzu, T. Kunieda, M. Yokoyama et al., A crucial role for adipose tissue p53 in the regulation of insulin resistance, Nature Medicine, vol.14, issue.9, pp.1082-1087, 2009.
DOI : 10.1038/nm.2014

E. Phillips and P. Mckinnon, DNA double-strand break repair and development, Oncogene, vol.18, issue.56, pp.7799-7808, 2007.
DOI : 10.1038/ncb1446

V. Kaddai, J. Jager, T. Gonzalez, R. Najem-lendom, S. Bonnafous et al., Involvement of TNF-?? in abnormal adipocyte and muscle sortilin expression in obese mice and humans, Diabetologia, vol.157, issue.5, pp.932-940, 2009.
DOI : 10.1007/s00125-009-1273-3

J. Jager, T. Grémeaux, T. Gonzalez, S. Bonnafous, C. Debard et al., Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1?? and Tumor Necrosis Factor-?? Effects on Extracellular Signal-Regulated Kinase Activation and Lipolysis, Diabetes, vol.59, issue.1, pp.61-70, 2010.
DOI : 10.2337/db09-0470

V. Kaddai, T. Gonzalez, F. Keslair, T. Grémeaux, S. Bonnafous et al., Rab4b Is a Small GTPase Involved in the Control of the Glucose Transporter GLUT4 Localization in Adipocyte, PLoS ONE, vol.38, issue.4, p.5257, 2009.
DOI : 10.1371/journal.pone.0005257.s006

S. Obba, Z. Hizir, L. Boyer, D. Selimoglu-buet, A. Pfeifer et al., The PRKAA1/AMPK??1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML, Autophagy, vol.11, issue.7, pp.1114-1129, 2015.
DOI : 10.4161/auto.19496

J. Jager, V. Corcelle, T. Gremeaux, K. Laurent, A. Waget et al., Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity, Diabetologia, vol.118, issue.1, pp.180-189, 2011.
DOI : 10.1007/s00125-010-1944-0

URL : https://hal.archives-ouvertes.fr/hal-00533842

M. Mari, P. Monzo, V. Kaddai, T. Gonzalez, L. Marchand-brustel et al., The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes, Journal of Cell Science, vol.119, issue.7, pp.1297-1306, 2006.
DOI : 10.1242/jcs.02850

J. Gilleron, W. Querbes, A. Zeigerer, A. Borodovsky, G. Marsico et al., Image-based analysis of lipid nanoparticle???mediated siRNA delivery, intracellular trafficking and endosomal escape, Nature Biotechnology, vol.20, issue.7, pp.638-646, 2013.
DOI : 10.1093/nar/gkq568

N. Renier, Z. Wu, D. Simon, J. Yang, P. Ariel et al., iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging, Cell, vol.159, issue.4, pp.896-910, 2014.
DOI : 10.1016/j.cell.2014.10.010

M. Ritchie, B. Phipson, D. Wu, Y. Hu, C. Law et al., limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Research, vol.43, issue.7, p.47, 2015.
DOI : 10.1093/nar/gkv007

V. Kaddai, T. Gonzalez, M. Bolla, L. Marchand-brustel, Y. Cormont et al., The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016, stimulates glucose transport and glucose transporters translocation in 3T3-L1 adipocytes, AJP: Endocrinology and Metabolism, vol.295, issue.1, pp.162-169, 2008.
DOI : 10.1152/ajpendo.00622.2007

M. Dizdaroglu and P. Jaruga, Mechanisms of free radical-induced damage to DNA, Free Radical Research, vol.297, issue.5, pp.382-419, 2012.
DOI : 10.1002/ijc.2910620313

D. Munoz-espin and M. Serrano, Cellular senescence: from physiology to pathology, Nature Reviews Molecular Cell Biology, vol.501, issue.7, pp.482-496, 2014.
DOI : 10.1038/nrm3823

A. Hock and K. Vousden, The role of ubiquitin modification in the regulation of p53, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1843, issue.1, pp.137-149, 2014.
DOI : 10.1016/j.bbamcr.2013.05.022

P. Arner and D. Langin, Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance, Trends in Endocrinology & Metabolism, vol.25, issue.5, pp.255-262, 2014.
DOI : 10.1016/j.tem.2014.03.002

URL : https://hal.archives-ouvertes.fr/inserm-01055325

D. Brasaemle, Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis, The Journal of Lipid Research, vol.48, issue.12, pp.2547-2559, 2007.
DOI : 10.1194/jlr.R700014-JLR200

N. Tanaka, S. Takahashi, T. Matsubara, C. Jiang, W. Sakamoto et al., Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice, Journal of Biological Chemistry, vol.290, issue.5, pp.3092-3105, 2015.
DOI : 10.1074/jbc.M114.605980

F. Ortega, J. Moreno-navarrete, D. Mayas, M. Serino, J. Rodriguez-hermosa et al., Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression, International Journal of Obesity, vol.19, issue.5, pp.735-745, 2014.
DOI : 10.2337/diab.35.9.990

M. Yokoyama, S. Okada, A. Nakagomi, J. Moriya, I. Shimizu et al., Inhibition of Endothelial p53 Improves Metabolic Abnormalities Related to Dietary Obesity, Cell Reports, vol.7, issue.5, pp.1691-1703, 2014.
DOI : 10.1016/j.celrep.2014.04.046

N. Inoue, N. Yahagi, T. Yamamoto, M. Ishikawa, K. Watanabe et al., Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance, Journal of Biological Chemistry, vol.283, issue.30, pp.21220-21229, 2008.
DOI : 10.1074/jbc.M801824200

M. Cooke, M. Evans, M. Dizdaroglu, and J. Lunec, Oxidative DNA damage: mechanisms, mutation, and disease, The FASEB Journal, vol.17, issue.10, pp.1195-1214, 2003.
DOI : 10.1096/fj.02-0752rev

J. Eriksson, Metabolic stress in insulin's target cells leads to ROS accumulation - A hypothetical common pathway causing insulin resistance, FEBS Letters, vol.444, issue.19, pp.3734-3742, 2007.
DOI : 10.1016/j.febslet.2007.06.044

V. Vieira-potter, Inflammation and macrophage modulation in adipose tissues, Cellular Microbiology, vol.211, issue.10, pp.1484-1492, 2014.
DOI : 10.1111/cmi.12336

G. Chatzinikolaou, I. Karakasilioti, and G. Garinis, DNA damage and innate immunity: links and trade-offs, Trends in Immunology, vol.35, issue.9, pp.429-435, 2014.
DOI : 10.1016/j.it.2014.06.003

B. Surmi and A. Hasty, The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue, Vascular Pharmacology, vol.52, issue.1-2, pp.27-36, 2009.
DOI : 10.1016/j.vph.2009.12.004