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Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.

Abstract : Highlights x Excitatory GABA effect was implemented in a computational neural mass model x Dynamic emergence of depolarizing GABA triggers interictal to ictal transitions x Results suggest a major role of GABAergic interneurons in seizure onset x Model reproduces clinical patterns found in a severe infantile epilepsy
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https://www.hal.inserm.fr/inserm-01341764
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Submitted on : Monday, July 4, 2016 - 5:14:51 PM
Last modification on : Wednesday, April 15, 2020 - 9:58:40 AM
Long-term archiving on: : Wednesday, October 5, 2016 - 3:01:47 PM

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Polina Kurbatova, Fabrice Wendling, Anna Kaminska, Anna Rosati, Rima Nabbout, et al.. Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.. Experimental Neurology, Elsevier, 2016, 283 (Pt A), pp.57-72. ⟨10.1016/j.expneurol.2016.05.037⟩. ⟨inserm-01341764⟩

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