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Cleaning and asthma characteristics in women.

Abstract : We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, immunological and inflammatory aspects. Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed). Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2-6.4)) and severe asthma (5.1(1.7-15.3)). An association was suggested for poorly controlled asthma (2.2(0.9-5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1-8.3)), with a low IgE level (2.8(1.2-6.2)), and with a low eosinophil count (3.2(1.5-7.1)). Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures.
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https://www.hal.inserm.fr/inserm-01324231
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Submitted on : Tuesday, May 31, 2016 - 5:17:44 PM
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U823 | UVSQ | EGEA | CESP | UGA

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Orianne Dumas, Valérie Siroux, Frédéric Luu, Rachel Nadif, Jan-Paul Zock, et al.. Cleaning and asthma characteristics in women.. American Journal of Industrial Medicine, Wiley, 2014, 57 (3), pp.303-11. ⟨10.1002/ajim.22244⟩. ⟨inserm-01324231⟩

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