Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study

AbstractIn human lung fibrotic lesions, fibroblasts were shown to be closely associated with immature dendritic cell (DC) accumulation. The aim of the present pilot study was to characterize the role of pulmonary fibroblasts on DC phenotype and function, using co-culture of lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) and from control patients, with a DC cell line MUTZ-3. We observed that co-culture of lung control and IPF fibroblasts with DCs reduced the expression of specific DC markers and down-regulated their T-cell stimulatory activity. This suggests that pulmonary fibroblasts might sustain chronic inflammation in the fibrotic lung by maintaining in situ a pool of immature DCs.

Mots clés

Lung Fibroblasts Dendritic cells Fibrosis

Domaines

Sciences du Vivant [q-bio]

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12931_2016_Article_345.pdf (1.03 Mo)

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https://inserm.hal.science/inserm-01322542

Soumis le : vendredi 27 mai 2016-11:43:03

Dernière modification le : jeudi 14 décembre 2023-13:50:37

Archivage à long terme le : dimanche 28 août 2016-10:32:02

Dates et versions

inserm-01322542 , version 1 (27-05-2016)

Identifiants

HAL Id : inserm-01322542 , version 1
DOI : 10.1186/s12931-016-0345-4
PUBMED : 27044262
PUBMEDCENTRAL : PMC4820963

Citer

Olivia Freynet, Joëlle Marchal-Sommé, Francette Jean-Louis, Arnaud Mailleux, Bruno Crestani, et al.. Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study. Respiratory Research, 2015, 17 (1), pp.36. ⟨10.1186/s12931-016-0345-4⟩. ⟨inserm-01322542⟩

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