J. Hoeijmakers, S. Burma, B. P. Chen, D. J. Chen, Y. Ma et al., Genome maintenance mechanisms for preventing cancer Role of non-homologous end joining (NHEJ) in maintaining genomic integrity The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination, Nature DNA Repair DNA Repair, vol.411, issue.3, pp.366-374, 2001.

S. J. Collis, T. L. Deweese, P. A. Jeggo, and A. R. Parker, The life and death of DNA-PK, Oncogene, vol.24, issue.6, pp.949-961, 2005.
DOI : 10.1038/sj.onc.1208332

D. W. Chan, C. H. Mody, N. S. Ting, and S. P. Lees-miller, Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta, Biochemistry and Cell Biology, vol.74, issue.1, pp.67-73, 1996.
DOI : 10.1139/o96-007

R. T. Abraham, PI 3-kinase related kinases: ???big??? players in stress-induced signaling pathways, DNA Repair, vol.3, issue.8-9, pp.883-887, 2004.
DOI : 10.1016/j.dnarep.2004.04.002

C. J. Bakkenist and M. B. Kastan, Initiating Cellular Stress Responses, Cell, vol.118, issue.1, pp.9-17, 2004.
DOI : 10.1016/j.cell.2004.06.023

X. Kong, Y. Shen, N. Jiang, X. Fei, and J. Mi, Emerging roles of DNA-PK besides DNA repair. Cell Signal, pp.1273-1280, 2011.

S. E. Lee, R. A. Mitchell, A. Cheng, and E. A. Hendrickson, Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle., Molecular and Cellular Biology, vol.17, issue.3, pp.1425-1433, 1997.
DOI : 10.1128/MCB.17.3.1425

H. Lucero, D. Gae, and G. Taccioli, Novel Localization of the DNA-PK Complex in Lipid Rafts: A PUTATIVE ROLE IN THE SIGNAL TRANSDUCTION PATHWAY OF THE IONIZING RADIATION RESPONSE, Journal of Biological Chemistry, vol.278, issue.24, pp.22136-22143, 2003.
DOI : 10.1074/jbc.M301579200

D. W. Chan, B. P. Chen, S. Prithivirajsingh, A. Kurimasa, M. D. Story et al., Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks, Genes & Development, vol.16, issue.18, pp.2333-2338, 2002.
DOI : 10.1101/gad.1015202

X. Cui, Y. Yu, S. Gupta, Y. M. Cho, S. P. Lees-miller et al., Autophosphorylation of DNA-Dependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice, Molecular and Cellular Biology, vol.25, issue.24, pp.10842-10852, 2005.
DOI : 10.1128/MCB.25.24.10842-10852.2005

Q. Ding, Y. V. Reddy, W. Wang, T. Woods, P. Douglas et al., Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair, Molecular and Cellular Biology, vol.23, issue.16, pp.5836-5848, 2003.
DOI : 10.1128/MCB.23.16.5836-5848.2003

P. Douglas, G. B. Moorhead, R. Ye, and S. P. Lees-miller, Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity, Journal of Biological Chemistry, vol.276, issue.22, pp.18992-18998, 2001.
DOI : 10.1074/jbc.M011703200

D. J. Chen and C. S. Nirodi, The Epidermal Growth Factor Receptor: A Role in Repair of Radiation-Induced DNA Damage, Clinical Cancer Research, vol.13, issue.22, pp.6555-6560, 2007.
DOI : 10.1158/1078-0432.CCR-07-1610

M. Kriegs, U. Kasten-pisula, T. Rieckmann, K. Holst, J. Saker et al., The epidermal growth factor receptor modulates DNA double-strand break repair by regulating non-homologous end-joining, DNA Repair, vol.9, issue.8, pp.889-897, 2010.
DOI : 10.1016/j.dnarep.2010.05.005

N. E. Hynes and G. Macdonald, ErbB receptors and signaling pathways in cancer, Current Opinion in Cell Biology, vol.21, issue.2, pp.177-184, 2009.
DOI : 10.1016/j.ceb.2008.12.010

J. Mendelsohn and J. Baselga, Epidermal Growth Factor Receptor Targeting in Cancer, Seminars in Oncology, vol.33, issue.4, pp.369-385, 2006.
DOI : 10.1053/j.seminoncol.2006.04.003

I. Szumiel, Epidermal growth factor receptor and DNA double strand break repair: The cell's self-defence, Cellular Signalling, vol.18, issue.10, pp.1537-1548, 2006.
DOI : 10.1016/j.cellsig.2006.03.010

S. E. Golding, R. N. Morgan, B. R. Adams, A. J. Hawkins, L. F. Povirk et al., Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells, Cancer Biology & Therapy, vol.8, issue.8, pp.730-738, 2009.
DOI : 10.4161/cbt.8.8.7927

D. Bandyopadhyay, M. Mandal, L. Adam, J. Mendelsohn, and R. Kumar, Physical Interaction between Epidermal Growth Factor Receptor and DNA-dependent Protein Kinase in Mammalian Cells, Journal of Biological Chemistry, vol.273, issue.3, pp.1568-1573, 1998.
DOI : 10.1074/jbc.273.3.1568

K. Dittmann, C. Mayer, B. Fehrenbacher, M. Schaller, U. Raju et al., Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase, Journal of Biological Chemistry, vol.280, issue.35, pp.31182-31189, 2005.
DOI : 10.1074/jbc.M506591200

K. Dittmann, C. Mayer, and H. P. Rodemann, Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity, Radiotherapy and Oncology, vol.76, issue.2, pp.157-161, 2005.
DOI : 10.1016/j.radonc.2005.06.022

M. Toulany, U. Kasten-pisula, I. Brammer, S. Wang, J. Chen et al., Blockage of Epidermal Growth Factor Receptor-Phosphatidylinositol 3-Kinase-AKT Signaling Increases Radiosensitivity of K-RAS Mutated Human Tumor Cells In vitro by Affecting DNA Repair, Clinical Cancer Research, vol.12, issue.13, pp.4119-4126, 2006.
DOI : 10.1158/1078-0432.CCR-05-2454

V. Sakanyan, M. Angelini, M. Le-bechec, M. F. Lecocq, F. Benaiteau et al., Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells, Scientific Reports, vol.9
DOI : 10.1038/srep03977
URL : https://hal.archives-ouvertes.fr/hal-01136283

R. G. Shao, C. X. Cao, H. Zhang, K. W. Kohn, M. S. Wold et al., Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes, The EMBO Journal, vol.18, issue.5, pp.1397-1406, 1999.
DOI : 10.1093/emboj/18.5.1397

I. Kouranti and A. Peyroche, Protein degradation in DNA damage response, Seminars in Cell & Developmental Biology, vol.23, issue.5, pp.538-545
DOI : 10.1016/j.semcdb.2012.02.004

R. Sakasai, H. Teraoka, and R. S. Tibbetts, Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin, DNA Repair, vol.9, issue.1, pp.76-82, 2010.
DOI : 10.1016/j.dnarep.2009.10.008

V. Sakanyan, P. Hulin, R. De-sousa, V. Silva, A. Hambardsumyan et al., Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1, Scientific Reports, vol.24, issue.1
DOI : 10.1074/mcp.M400181-MCP200
URL : https://hal.archives-ouvertes.fr/hal-01279094

D. Davidson, L. Amrein, and L. Panasci, Aloyz, R. Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond, Front. Pharmacol

M. E. Dolman, I. Van-der-ploeg, J. Koster, L. T. Bate-eya, R. Versteeg et al., DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells, PLOS ONE, vol.21, issue.1, p.145744, 2015.
DOI : 10.1371/journal.pone.0145744.s003

B. P. Chen, N. Uematsu, J. Kobayashi, Y. Lerenthal, A. Krempler et al., Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break, Journal of Biological Chemistry, vol.282, issue.9, pp.6582-6587, 2007.
DOI : 10.1074/jbc.M611605200

X. Jiang, Y. Sun, S. Chen, K. Roy, and B. D. Price, The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM, Journal of Biological Chemistry, vol.281, issue.23, pp.15741-15746, 2006.
DOI : 10.1074/jbc.M513172200

B. Mukherjee, C. Kessinger, J. Kobayashi, B. P. Chen, D. J. Chen et al., DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells, DNA Repair, vol.5, issue.5, pp.575-590, 2006.
DOI : 10.1016/j.dnarep.2006.01.011

P. Y. Wu, P. Frit, L. Malivert, P. Revy, D. Biard et al., Interplay between Cernunnos-XLF and Nonhomologous End-joining Proteins at DNA Ends in the Cell, Journal of Biological Chemistry, vol.282, issue.44, pp.31937-31943, 2007.
DOI : 10.1074/jbc.M704554200

R. W. Anantha, V. M. Vassin, and J. A. Borowiec, Sequential and Synergistic Modification of Human RPA Stimulates Chromosomal DNA Repair, Journal of Biological Chemistry, vol.282, issue.49, pp.35910-35923, 2007.
DOI : 10.1074/jbc.M704645200

R. Sakasai, K. Shinohe, Y. Ichijima, N. Okita, A. Shibata et al., Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks, Genes to Cells, vol.158, issue.3, pp.237-246, 2006.
DOI : 10.1074/jbc.272.38.23896

A. Salmeen, J. N. Andersen, M. P. Myers, T. C. Meng, J. A. Hinks et al., Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate, Nature, vol.423, issue.6941, pp.769-773, 2003.
DOI : 10.1038/nature01680

C. E. Paulsen, T. H. Truong, F. J. Garcia, A. Homann, V. Gupta et al., Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity, Nature Chemical Biology, vol.473, issue.1, pp.57-64, 2012.
DOI : 10.1002/anie.201007175

E. V. Patridge, E. S. Eriksson, P. G. Penketh, R. P. Baumann, R. Zhu et al., 7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide, Archives of Toxicology, vol.17, issue.1, pp.1613-1625, 2012.
DOI : 10.1007/s00204-012-0872-9

Y. P. Li, Y. Chen, A. S. Li, and M. B. Reid, Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes, AJP: Cell Physiology, vol.285, issue.4, pp.806-812, 2003.
DOI : 10.1152/ajpcell.00129.2003

H. R. Lu, H. Zhu, M. Huang, Y. Chen, Y. J. Cai et al., Reactive Oxygen Species Elicit Apoptosis by Concurrently Disrupting Topoisomerase II and DNA-Dependent Protein Kinase, Molecular Pharmacology, vol.68, issue.4, pp.983-994, 2005.
DOI : 10.1124/mol.105.011544

C. Muller, P. Calsou, P. Frit, C. Cayrol, T. Carter et al., UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells, Nucleic Acids Research, vol.26, issue.6, pp.1382-1389, 1998.
DOI : 10.1093/nar/26.6.1382

P. Peddi, C. W. Loftin, J. S. Dickey, J. M. Hair, K. J. Burns et al., DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells. Free Radic, Biol. Med, vol.48, pp.1435-1443, 2010.