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Repetitive Transcranial Magnetic Stimulation to Supplementary Motor Area in Refractory Obsessive-Compulsive Disorder Treatment: a Sham-Controlled Trial

Abstract : BACKGROUND: Repetitive transcranial magnetic stimulation has been explored in patients with obsessive-compulsive disorder, but with negative or conflicting results. This randomized double-blind study was designed to assess the efficacy of 1-Hz repetitive transcranial magnetic stimulation over the presupplementary area. METHODS: Forty medication-resistant patients were assigned to 4 weeks of either active or sham repetitive transcranial magnetic stimulation targeting the presupplementary area with the help of a neuronavigation system. RESULTS: According to the Yale-Brown obsessive-compulsive scale, the baseline-week 4 evolution showed no significant differences between groups. Responder rates at week 4 were not different between groups (repetitive transcranial magnetic stimulation 10.5% vs sham 20%; P=.63). CONCLUSION: Low-frequency repetitive transcranial magnetic stimulation applied to the presupplementary area seems ineffective for the treatment of obsessive-compulsive disorder patients, at least in severe and drug-refractory cases such as those included in this study. Further research is required to determine profiles of responder patients and appropriate repetitive transcranial magnetic stimulation parameters for obsessive-compulsive disorder.
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https://www.hal.inserm.fr/inserm-01320112
Contributor : Antoine Pelissolo <>
Submitted on : Monday, May 23, 2016 - 2:23:19 PM
Last modification on : Wednesday, August 19, 2020 - 11:18:10 AM

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Antoine Pelissolo, Ghina Harika-Germaneau, Fady Rachid, Christian Gaudeau-Bosma, Marie-Laure Tanguy, et al.. Repetitive Transcranial Magnetic Stimulation to Supplementary Motor Area in Refractory Obsessive-Compulsive Disorder Treatment: a Sham-Controlled Trial. International Journal of Neuropsychopharmacology, Oxford University Press (OUP), 2016, [Epub ahead of print]. ⟨10.1093/ijnp/pyw025⟩. ⟨inserm-01320112⟩

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