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Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
Abstract : There are still unmet medical needs in the treatment of glioblastoma, the
most common and the most aggressive glioma of all brain tumors. Here, we found
that O-acetyl GD2 is expressed in surgically resected human glioblastoma tissue.
In addition, we demonstrated that 8B6 monoclonal antibody specific for O-acetylat
GD2 could effectively inhibit glioblastoma cell proliferation in vitro and in vivo. Taken
together, these results indicate that O-acetylated GD2 represents a novel antigen for
immunotherapeutic-based treatment of high-grade gliomas.
Cited literature [25 references]
https://www.hal.inserm.fr/inserm-01319327
Contributor : Elizabeth Bernardo <>
Submitted on : Friday, May 20, 2016 - 4:05:23 PM
Last modification on : Thursday, February 7, 2019 - 3:12:18 PM
Contributor : Elizabeth Bernardo <>
Submitted on : Friday, May 20, 2016 - 4:05:23 PM
Last modification on : Thursday, February 7, 2019 - 3:12:18 PM
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