Abstract : There are still unmet medical needs in the treatment of glioblastoma, the
most common and the most aggressive glioma of all brain tumors. Here, we found
that O-acetyl GD2 is expressed in surgically resected human glioblastoma tissue.
In addition, we demonstrated that 8B6 monoclonal antibody specific for O-acetylat
GD2 could effectively inhibit glioblastoma cell proliferation in vitro and in vivo. Taken
together, these results indicate that O-acetylated GD2 represents a novel antigen for
immunotherapeutic-based treatment of high-grade gliomas.
