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Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease.

François de Guio 1, 2 Eric Jouvent 1, 2, 3 Geert Jan Biessels 4 Sandra E Black 5 Carol Brayne 6 Christopher Chen 7 Charlotte Cordonnier 8 Frank-Eric de Leeuw 9 Martin Dichgans 10, 11 Fergus Doubal 12 Marco Duering 11 Carole Dufouil 13 Emrah Duzel 14 Franz Fazekas 15 Vladimir Hachinski 16 Arfan M Ikram 17, 18 Jennifer Linn 19 Paul M Matthews 20 Bernard Mazoyer 21 Vincent Mok 22 Bo Norrving 23 John T O'Brien 24 Leonardo Pantoni 25 Stefan Ropele 15 Perminder Sachdev 26 Reinhold Schmidt 27 Sudha Seshadri 28 Eric E Smith 29 Luciano A Sposato 16 Blossom Stephan 30 Richard H Swartz 5 Christophe Tzourio 13 Mark van Buchem 31 Aad van Der Lugt 17 Robert van Oostenbrugge 32 Meike W Vernooij 17, 18 Anand Viswanathan 33 David Werring 34 Frank Wollenweber 11 Joanna M Wardlaw 35, 12 Hugues Chabriat 1, 2, 3, * 
* Corresponding author
Abstract : Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.
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Submitted on : Wednesday, May 18, 2016 - 7:00:42 PM
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François de Guio, Eric Jouvent, Geert Jan Biessels, Sandra E Black, Carol Brayne, et al.. Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease.. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2016, 36 (8), pp.1319-37. ⟨10.1177/0271678X16647396⟩. ⟨inserm-01317759⟩



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