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Imaging ROS-induced modifications in living systems 4 5

Abstract : Significance: Reactive Oxygen Species (ROS) mayregulatesignaling, ion channels, transcription factors and biosynthetic processes. ROS-related diseases can be either due to a shortage or to an excess of ROS. Recent advances: Since biological activity of ROSdepends on not only concentration but also spatial and temporal distribution, real-time imagingof ROS, possibly “invivo”, has be-come a need for scientists,with potential for clinical translation. New imaging techniques, as well as new contrast agents in clinically established modalities, was developed in the last decade. Critical issues: An ideal imaging technique should determine ROS changeswith high spatio-temporal resolution, detectphysiologically relevant variations in ROS concentration and provide specificity towards different redox couples. Furthermore, for invivoapplications, bioavailability of sensors, tissue penetrationand a highsignal-to-noise ratio are additional requirements to be satisfied. Future directions: None of the presented techniques fulfill all requirements for clinical translation. The obvious way forward is to incorporate anatomical and functional imaging into a common hybrid-imaging platform.
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Submitted on : Monday, May 9, 2016 - 3:57:15 PM
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  • HAL Id : inserm-01313147, version 1
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Giuseppe Maulucci, Goran Bačić, Lori Bridal, Harald Hhw Schmidt, Bertrand Tavitian, et al.. Imaging ROS-induced modifications in living systems 4 5. Antioxidants and Redox Signaling, Mary Ann Liebert, 2016, 24 (16), pp.939-58. ⟨inserm-01313147⟩



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