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J. Frijhoff, Clinical Relevance of Biomarkers of Oxidative Stress, Antioxidants & Redox Signaling, vol.23, issue.14, 2015.
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U. Jahn, J. M. Galano, and T. Durand, Beyond prostaglandins--chemistry and biology of cyclic oxygenated metabolites formed by freeradical pathways from polyunsaturated fatty acids, Angew Chem Int Ed Engl, issue.32, pp.47-5894, 2008.

G. L. Milne, Isoprostane Generation and Function, Chemical Reviews, vol.111, issue.10, pp.5973-96, 2011.
DOI : 10.1021/cr200160h

R. Milne and S. Brownstein, Advanced glycation end products and diabetic retinopathy, Amino Acids, vol.53, issue.112, pp.1397-407, 2013.
DOI : 10.1007/s00726-011-1071-3

G. L. Milne, Q. Dai, and L. J. Roberts, The isoprostanes???25 years later, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1851, issue.4, pp.1851-433, 2015.
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L. Minghetti, Nonenzymatic oxygenated metabolites of alpha-linolenic acid B1-and L1-phytoprostanes protect immature neurons from oxidant injury and promote differentiation of oligodendrocyte progenitors through PPAR-gamma activation, Free Radic Biol Med, issue.73, pp.41-50, 2014.

J. M. Galano, Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and alpha-linolenic acids; bioactivities and potential use as biomarkers, Biochim Biophys Acta, issue.4, pp.1851-446, 2015.

C. Gladine, Neuroprostanes, produced by free-radical mediated peroxidation of DHA, inhibit the inflammatory response of human macrophages, Free Radical Biology and Medicine, vol.75, issue.1, pp.75-90, 2014.
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J. M. Galano, Special Issue onAnalytical Methods for Oxidized Biomolecules and Antioxidants" The use of isoprostanoids as biomarkers of oxidative damage, and their role in human dietary intervention studies, Free Radic Res, vol.11, issue.5, pp.49-583, 2015.

J. Klawitter, Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared, Rapid Communications in Mass Spectrometry, vol.399, issue.4, pp.463-471, 2011.
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C. Vigor, Non-enzymatic lipid oxidation products in biological systems: Assessment of the metabolites from polyunsaturated fatty acids, Journal of Chromatography B, vol.964, pp.65-78, 2014.
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URL : https://hal.archives-ouvertes.fr/hal-01058094

T. Durand, Syntheses and preliminary pharmacological evaluation of the two epimers of the 5-F-2t-isoprostane, Bioorganic & Medicinal Chemistry Letters, issue.1118, pp.2495-2498, 2001.

T. Durand, Total syntheses of four metabolites of 15-F-2t-isoprostane, European Journal of Organic Chemistry, issue.4, pp.809-819, 2001.

T. Durand, Total synthesis of (15R)-and (15S)-F-2t-isoprostanes by a biomimetic process using the cyclization of acyclic dihydroxylated octa-5,7-dienyl radicals, Journal of Organic Chemistry, issue.11, pp.67-3615, 2002.

E. Fangour and S. , Total synthesis of the eight diastereomers of the syn-anti-syn phytoprostanes F1 types I and II, J Org Chem, issue.7, pp.69-2498, 2004.

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DOI : 10.1016/S0040-4039(98)01290-8

J. Frijhoff, Clinical Relevance of Biomarkers of Oxidative Stress, Antioxidants & Redox Signaling, vol.23, issue.14, 2015.
DOI : 10.1089/ars.2015.6317

U. Jahn, J. M. Galano, and T. Durand, Beyond prostaglandins--chemistry and biology of cyclic oxygenated metabolites formed by freeradical pathways from polyunsaturated fatty acids, Angew Chem Int Ed Engl, issue.32, pp.47-5894, 2008.

G. L. Milne, Isoprostane Generation and Function, Chemical Reviews, vol.111, issue.10, pp.5973-96, 2011.
DOI : 10.1021/cr200160h

R. Milne and S. Brownstein, Advanced glycation end products and diabetic retinopathy, Amino Acids, vol.53, issue.112, pp.1397-407, 2013.
DOI : 10.1007/s00726-011-1071-3

G. L. Milne, Q. Dai, and L. J. Roberts, The isoprostanes???25 years later, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1851, issue.4, pp.1851-433, 2015.
DOI : 10.1016/j.bbalip.2014.10.007

L. Minghetti, Nonenzymatic oxygenated metabolites of alpha-linolenic acid B1-and L1-phytoprostanes protect immature neurons from oxidant injury and promote differentiation of oligodendrocyte progenitors through PPAR-gamma activation, Free Radic Biol Med, issue.73, pp.41-50, 2014.

J. M. Galano, Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and alpha-linolenic acids; bioactivities and potential use as biomarkers, Biochim Biophys Acta, issue.4, pp.1851-446, 2015.

C. Gladine, Neuroprostanes, produced by free-radical mediated peroxidation of DHA, inhibit the inflammatory response of human macrophages, Free Radical Biology and Medicine, vol.75, issue.1, pp.75-90, 2014.
DOI : 10.1016/j.freeradbiomed.2014.10.590

J. M. Galano, Special Issue onAnalytical Methods for Oxidized Biomolecules and Antioxidants" The use of isoprostanoids as biomarkers of oxidative damage, and their role in human dietary intervention studies, Free Radic Res, vol.11, issue.5, pp.49-583, 2015.

J. Klawitter, Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared, Rapid Communications in Mass Spectrometry, vol.399, issue.4, pp.463-471, 2011.
DOI : 10.1002/rcm.4871

C. Vigor, Non-enzymatic lipid oxidation products in biological systems: Assessment of the metabolites from polyunsaturated fatty acids, Journal of Chromatography B, vol.964, pp.65-78, 2014.
DOI : 10.1016/j.jchromb.2014.04.042

URL : https://hal.archives-ouvertes.fr/hal-01058094

T. Durand, Syntheses and preliminary pharmacological evaluation of the two epimers of the 5-F-2t-isoprostane, Bioorganic & Medicinal Chemistry Letters, issue.1118, pp.2495-2498, 2001.

T. Durand, Total syntheses of four metabolites of 15-F-2t-isoprostane, European Journal of Organic Chemistry, issue.4, pp.809-819, 2001.

T. Durand, Total synthesis of (15R)-and (15S)-F-2t-isoprostanes by a biomimetic process using the cyclization of acyclic dihydroxylated octa-5,7-dienyl radicals, Journal of Organic Chemistry, issue.11, pp.67-3615, 2002.

E. Fangour and S. , Total synthesis of the eight diastereomers of the syn-anti-syn phytoprostanes F1 types I and II, J Org Chem, issue.7, pp.69-2498, 2004.

A. Guy, Total synthesis of ent-15(RS)-2,3-dinor-5,6-dihydro-8-epi-PGF2??, Tetrahedron Letters, vol.39, issue.34, pp.6181-6184, 1998.
DOI : 10.1016/S0040-4039(98)01290-8

. Ent-15, RS)-2,3-dinor- 5,6-dihydro-15-F 2t -IsoP 62