E. Abraham, J. Arcaroli, A. Carmody, H. Wang, and K. J. Tracey, Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation, The Journal of Immunology, vol.165, issue.6, pp.2950-2954, 2000.
DOI : 10.4049/jimmunol.165.6.2950

D. Agnello, H. Wang, H. Yang, K. J. Tracey, and P. Ghezzi, HMGB-1, A DNA-BINDING PROTEIN WITH CYTOKINE ACTIVITY, INDUCES BRAIN TNF AND IL-6 PRODUCTION, AND MEDIATES ANOREXIA AND TASTE AVERSION, Cytokine, vol.18, issue.4, pp.231-236, 2002.
DOI : 10.1006/cyto.2002.0890

K. Benchenane, V. Berezowski, C. Ali, M. Fernandez-monreal, J. P. Lopez-atalaya et al., Tissue-Type Plasminogen Activator Crosses the Intact Blood-Brain Barrier by Low-Density Lipoprotein Receptor-Related Protein-Mediated Transcytosis, Circulation, vol.111, issue.17, pp.2241-2249, 2005.
DOI : 10.1161/01.CIR.0000163542.48611.A2

URL : https://hal.archives-ouvertes.fr/hal-00542121

K. Benchenane, V. Berezowski, M. Fernandez-monreal, J. Brillault, S. Valable et al., Oxygen Glucose Deprivation Switches the Transport of tPA Across the Blood-Brain Barrier From an LRP-Dependent to an Increased LRP-Independent Process, Stroke, vol.36, issue.5, pp.1065-1070, 2005.
DOI : 10.1161/01.STR.0000163050.39122.4f

URL : https://hal.archives-ouvertes.fr/hal-00542010

K. Benchenane, H. Castel, M. Boulouard, R. Bluthe, M. Fernandez-monreal et al., Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory, Journal of Cell Science, vol.120, issue.4, pp.578-585, 2007.
DOI : 10.1242/jcs.03354

URL : https://hal.archives-ouvertes.fr/hal-00178289

T. Bonaldi, F. Talamo, P. Scaffidi, D. Ferrera, A. Porto et al., Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion, The EMBO Journal, vol.22, issue.20, pp.5551-5560, 2003.
DOI : 10.1093/emboj/cdg516

J. Brillault, V. Berezowski, R. Cecchelli, and M. P. Dehouck, Intercommunications between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood-brain barrier during ischaemia, Journal of Neurochemistry, vol.9, issue.4, pp.807-817, 2002.
DOI : 10.1046/j.1471-4159.2002.01186.x

URL : https://hal.archives-ouvertes.fr/hal-00525298

M. Bustin, Regulation of DNA-Dependent Activities by the Functional Motifs of the High-Mobility-Group Chromosomal Proteins, Molecular and Cellular Biology, vol.19, issue.8, pp.5237-5246, 1999.
DOI : 10.1128/MCB.19.8.5237

M. Culot, C. Mysiorek, M. Renftel, B. D. Roussel, Y. Hommet et al., Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study, Brain Research, vol.1294, pp.144-152, 2009.
DOI : 10.1016/j.brainres.2009.07.035

URL : https://hal.archives-ouvertes.fr/hal-00544037

M. P. Dehouck, S. Meresse, P. Delorme, J. C. Fruchart, and R. Cecchelli, An Easier, Reproducible, and Mass-Production Method to Study the Blood?Brain Barrier In Vitro, Journal of Neurochemistry, vol.214, issue.5, pp.1798-1801, 1990.
DOI : 10.1002/jemt.1060010412

URL : https://hal.archives-ouvertes.fr/hal-00523911

M. P. Dehouck, P. Jolliet-riant, F. Bree, J. C. Fruchart, R. Cecchelli et al., Drug Transfer Across the Blood-Brain Barrier: Correlation Between In Vitro and In Vivo Models, Journal of Neurochemistry, vol.2, issue.5, pp.1790-1797, 1992.
DOI : 10.1038/285041a0

URL : https://hal.archives-ouvertes.fr/hal-00529693

U. Dirnagl, C. Iadecola, and M. A. Moskowitz, Pathobiology of ischaemic stroke: an integrated view, Trends in Neurosciences, vol.22, issue.9, pp.391-397, 1999.
DOI : 10.1016/S0166-2236(99)01401-0

G. Faraco, S. Fossati, M. E. Bianchi, M. Patrone, M. Pedrazzi et al., High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo, Journal of Neurochemistry, vol.297, issue.part 1, pp.590-603, 2007.
DOI : 10.1111/j.1471-4159.2007.04788.x

W. Hacke, M. Kaste, E. Bluhmki, M. Brozman, A. Davalos et al., Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke, New England Journal of Medicine, vol.359, issue.13, pp.1317-1329, 2008.
DOI : 10.1056/NEJMoa0804656

K. Hayakawa, K. Mishima, M. Nozako, M. Hazekawa, S. Mishima et al., Delayed Treatment With Minocycline Ameliorates Neurologic Impairment Through Activated Microglia Expressing a High-Mobility Group Box1-Inhibiting Mechanism, Stroke, vol.39, issue.3, pp.951-958, 2008.
DOI : 10.1161/STROKEAHA.107.495820

K. Hayakawa, K. Arai, and E. H. Lo, Role of ERK map kinase and CRM1 in IL- 1beta-stimulated release of HMGB1 from cortical astrocytes, Glia, vol.58, pp.1007-1015, 2010.

K. Hayakawa, J. Qiu, and E. H. Lo, Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke, Annals of the New York Academy of Sciences, vol.35, issue.1, pp.50-57, 2010.
DOI : 10.1111/j.1749-6632.2010.05728.x

J. B. Kim, S. Choi, J. Yu, Y. M. Nam, K. Piao et al., HMGB1, a Novel Cytokine-Like Mediator Linking Acute Neuronal Death and Delayed Neuroinflammation in the Postischemic Brain, Journal of Neuroscience, vol.26, issue.24, pp.6413-6421, 2006.
DOI : 10.1523/JNEUROSCI.3815-05.2006

M. Kvajo, H. Albrecht, M. Meins, U. Hengst, E. Troncoso et al., Regulation of Brain Proteolytic Activity Is Necessary for the In Vivo Function of NMDA Receptors, Journal of Neuroscience, vol.24, issue.43, pp.9734-9743, 2004.
DOI : 10.1523/JNEUROSCI.3306-04.2004

D. Landsman and M. Bustin, A signature for the HMG-1 box DNA-binding proteins, BioEssays, vol.12, issue.8, pp.539-546, 1993.
DOI : 10.1002/bies.950150807

K. Liu, S. Mori, H. K. Takahashi, Y. Tomono, H. Wake et al., Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats, The FASEB Journal, vol.21, issue.14, pp.3904-3916, 2007.
DOI : 10.1096/fj.07-8770com

J. P. Lopez-atalaya, B. D. Roussel, C. Ali, E. Maubert, K. U. Petersen et al., Recombinant Desmodus rotundus Salivary Plasminogen Activator Crosses the Blood-Brain Barrier Through a Low-Density Lipoprotein Receptor-Related Protein-Dependent Mechanism Without Exerting Neurotoxic Effects, Stroke, vol.38, issue.3, pp.1036-1043, 2007.
DOI : 10.1161/01.STR.0000258100.04923.84

URL : https://hal.archives-ouvertes.fr/hal-00543483

J. P. Lopez-atalaya, B. D. Roussel, D. Levrat, J. Parcq, O. Nicole et al., Toward Safer Thrombolytic Agents in Stroke: Molecular Requirements for NMDA Receptor-Mediated Neurotoxicity, Journal of Cerebral Blood Flow & Metabolism, vol.384, issue.6, pp.1212-1221, 2008.
DOI : 10.1056/NEJM199512143332401

S. Muhammad, W. Barakat, S. Stoyanov, S. Murikinati, H. Yang et al., The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage, Journal of Neuroscience, vol.28, issue.46, pp.12023-12031, 2008.
DOI : 10.1523/JNEUROSCI.2435-08.2008

C. Mysiorek, M. Culot, L. Dehouck, B. Derudas, B. Staels et al., Peroxisome Proliferator-Activated Receptor-α Activation Protects Brain Capillary Endothelial Cells from Oxygen-Glucose Deprivation-Induced Hyperpermeability in the Blood-Brain Barrier, Current Neurovascular Research, vol.6, issue.3, pp.181-193, 2009.
DOI : 10.2174/156720209788970081

O. Nicole, F. Docagne, C. Ali, I. Margaill, P. Carmeliet et al., The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling, Nat. Med, vol.7, pp.59-64, 2001.

J. Parkkinen and H. Rauvala, Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin, J. Biol. Chem, vol.266, pp.16730-16735, 1991.

J. Qiu, M. Nishimura, Y. Wang, J. R. Sims, S. Qiu et al., Early Release of HMGB-1 from Neurons after the Onset of Brain Ischemia, Journal of Cerebral Blood Flow & Metabolism, vol.78, issue.5, pp.927-938, 2008.
DOI : 10.1126/science.285.5425.248

J. Qiu, J. Xu, Y. Zheng, Y. Wei, X. Zhu et al., High-Mobility Group Box 1 Promotes Metalloproteinase-9 Upregulation Through Toll-Like Receptor 4 After Cerebral Ischemia, Stroke, vol.41, issue.9, pp.2077-2082, 2010.
DOI : 10.1161/STROKEAHA.110.590463

A. Rouhiainen, S. Tumova, L. Valmu, N. Kalkkinen, and H. Rauvala, Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin), Journal of Leukocyte Biology, vol.81, issue.1, pp.49-58, 2007.
DOI : 10.1189/jlb.0306200

A. L. Samson and R. L. Medcalf, Tissue-Type Plasminogen Activator: A Multifaceted Modulator of Neurotransmission and Synaptic Plasticity, Neuron, vol.50, issue.5, pp.673-678, 2006.
DOI : 10.1016/j.neuron.2006.04.013

A. L. Samson, S. T. Nevin, D. Croucher, B. Niego, P. B. Daniel et al., Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function, Journal of Neurochemistry, vol.20, pp.1091-1101, 2008.
DOI : 10.1111/j.1471-4159.2008.05687.x

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198853

M. Saqqur, G. Tsivgoulis, C. A. Molina, A. M. Demchuk, M. Siddiqui et al., Symptomatic intracerebral hemorrhage and recanalization after IV rt-PA: A multicenter study, Neurology, vol.71, issue.17, pp.1304-1312, 2008.
DOI : 10.1212/01.wnl.0000313936.15842.0d

Y. Sha, J. Zmijewski, Z. Xu, and E. Abraham, HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines, The Journal of Immunology, vol.180, issue.4, pp.2531-2537, 2008.
DOI : 10.4049/jimmunol.180.4.2531

P. Tanswell, E. Seifried, P. C. Su, W. Feuerer, and D. C. Rijken, Pharmacokinetics and systemic effects of tissue-type plasminogen activator in normal subjects, Clinical Pharmacology and Therapeutics, vol.46, issue.2, pp.155-162, 1989.
DOI : 10.1038/clpt.1989.120

J. Tian, A. M. Avalos, S. Y. Mao, B. Chen, K. Senthil et al., Toll-like receptor 9???dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE, Nature Immunology, vol.198, issue.5, pp.487-496, 2007.
DOI : 10.1038/ni1457

S. E. Tsirka, A. Gualandris, D. G. Amaral, and S. Strickland, Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator, Nature, vol.377, issue.6547, pp.340-344, 1995.
DOI : 10.1038/377340a0

J. D. Vassalli, A. P. Sappino, and D. Belin, The plasminogen activator/plasmin system., Journal of Clinical Investigation, vol.88, issue.4, pp.1067-1072, 1991.
DOI : 10.1172/JCI115405

H. Wang, O. Bloom, M. Zhang, J. M. Vishnubhakat, M. Ombrellino et al., HMG-1 as a Late Mediator of Endotoxin Lethality in Mice, Science, vol.285, issue.5425, pp.248-251, 1999.
DOI : 10.1126/science.285.5425.248

X. Wang, A. Rosell, and E. H. Lo, Targeting Extracellular Matrix Proteolysis for Hemorrhagic Complications of tPA Stroke Therapy, CNS & Neurological Disorders - Drug Targets, vol.7, issue.3, pp.235-242, 2008.
DOI : 10.2174/187152708784936635

M. Yepes, B. D. Roussel, C. Ali, and D. Vivien, Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic, Trends in Neurosciences, vol.32, issue.1, pp.48-55, 2009.
DOI : 10.1016/j.tins.2008.09.006

URL : https://hal.archives-ouvertes.fr/inserm-01296642