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No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.

Abstract : A hybrid allele between the carboxyl ester lipase gene (CEL) and its pseudogene, CELP (called CEL–HYB), generated by non-allelic homologous recombination between CEL intron 10 and CELP intron 10′, was found to increase susceptibility to chronic pancreatitis in a case–control study of patients of European ancestry. We attempted to replicate this finding in 3 independent cohorts from China, Japan, and India, but failed to detect the CEL–HYB allele in any of these populations. The CEL–HYB allele might therefore be an ethnic-specific risk factor for chronic pancreatitis. An alternative hybrid allele (CEL–HYB2) was identified in all 3 Asian populations (1.7% combined carrier frequency), but was not associated with chronic pancreatitis.
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https://www.hal.inserm.fr/inserm-01293422
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Submitted on : Thursday, March 24, 2016 - 4:26:34 PM
Last modification on : Tuesday, June 9, 2020 - 3:22:06 PM
Long-term archiving on: : Saturday, June 25, 2016 - 2:20:15 PM

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Wen-Bin Zou, Arnaud Boulling, Atsushi Masamune, Prachand Issarapu, Emmanuelle Masson, et al.. No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.. Gastroenterology, WB Saunders, 2016, ⟨10.1053/j.gastro.2016.02.071⟩. ⟨inserm-01293422⟩

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