Skip to Main content Skip to Navigation
Journal articles

The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer

Abstract : AbstrAct Protein phosphorylation on tyrosine (Tyr) residues has evolved as an important mechanism to coordinate cell communication in multicellular organisms. The importance of this process has been revealed by the discovery of the prominent oncogenic properties of tyrosine kinases (TK) upon deregulation of their physiological activities, often due to protein overexpression and/or somatic mutation. Recent reports suggest that TK oncogenic signaling is also under the control of small adaptor proteins. These cytosolic proteins lack intrinsic catalytic activity and signal by linking two functional members of a catalytic pathway. While most adaptors display positive regulatory functions, a small group of this family exerts negative regulatory functions by targeting several components of the TK signaling cascade. Here, we review how these less studied adaptor proteins negatively control TK activities and how their loss of function induces abnormal TK signaling, promoting tumor formation. We also discuss the therapeutic consequences of this novel regulatory mechanism in human oncology.
Document type :
Journal articles
Complete list of metadatas

Cited literature [189 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01292961
Contributor : Mireille Bos <>
Submitted on : Thursday, March 24, 2016 - 10:07:41 AM
Last modification on : Tuesday, March 24, 2020 - 1:34:22 AM
Long-term archiving on: : Monday, November 14, 2016 - 3:45:42 AM

File

6929-105190-4-PB.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Cécile Naudin, Clément Chevalier, Serge Roche. The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer. Oncotarget, Impact journals, 2016, 7, pp.11033-11055. ⟨10.18632/oncotarget.6929⟩. ⟨inserm-01292961⟩

Share

Metrics

Record views

360

Files downloads

912