G. A. Alencar, ARMC5 Mutations Are a Frequent Cause of Primary Macronodular Adrenal 522

L. Gagliardi, Mutations Are Common in Familial Bilateral Macronodular Adrenal Hyperplasia, The Journal of Clinical Endocrinology & Metabolism, vol.99, issue.9, pp.1784-1792, 2014.
DOI : 10.1210/jc.2014-1265

S. Espiard, ARMC5 Mutations in a Large Cohort of Primary Macronodular Adrenal 526

. Hyperplasia, Clinical and Functional Consequences, J. Clin. Endocrinol. Metab, vol.100, pp.926-935, 2015.

E. Louiset, Intraadrenal Corticotropin in Bilateral Macronodular Adrenal Hyperplasia, New England Journal of Medicine, vol.369, issue.22, p.529
DOI : 10.1056/NEJMoa1215245

E. Ghorayeb, N. Bourdeau, I. Lacroix, and A. , Multiple aberrant hormone receptors in Cushing's syndrome, European Journal of Endocrinology, vol.173, issue.4, pp.45-60, 2015.
DOI : 10.1530/EJE-15-0200

G. Assié, Integrated genomic characterization of adrenocortical carcinoma, Nature Genetics, vol.11, issue.6, pp.607-612, 2014.
DOI : 10.1038/ng.2953

M. Antonio and . Lerario, in Late-Breaking Adrenal/HPA Axis II LBF, pp.73-073, 2015.

C. C. Juhlin, Whole-Exome Sequencing Characterizes the Landscape of Somatic Mutations and Copy Number Alterations in Adrenocortical Carcinoma, The Journal of Clinical Endocrinology & Metabolism, vol.100, issue.3, pp.493-539, 2015.
DOI : 10.1210/jc.2014-3282

J. S. Ross, Next-generation sequencing of adrenocortical carcinoma reveals new routes to targeted therapies, Journal of Clinical Pathology, vol.46, issue.11, pp.968-973, 2014.
DOI : 10.1136/jclinpath-2014-202514

D. Martino and M. C. , Molecular Screening for a Personalized Treatment Approach in Advanced 543

H. Hao, ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner, Nature, vol.39, issue.7397, p.545
DOI : 10.1038/nature11019

J. Zhao, Combined comparative genomic hybridization and genomic microarray for detection of gene amplifications in pulmonary artery intimal sarcomas and adrenocortical tumors, Genes, Chromosomes and Cancer, vol.157, issue.1, pp.48-57, 2002.
DOI : 10.1002/gcc.10035

B. Ragazzon, Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas, European Journal of Endocrinology, vol.170, issue.3, pp.385-391, 2014.
DOI : 10.1530/EJE-13-0778

G. Ciriello, Emerging landscape of oncogenic signatures across human cancers, Nature Genetics, vol.63, issue.10, pp.1127-1133, 2013.
DOI : 10.1016/j.csda.2006.11.025

T. J. Giordano, Distinct Transcriptional Profiles of Adrenocortical Tumors Uncovered by DNA 554

D. Velázquez-fernández, Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy, Surgery, vol.138, issue.6, pp.1087-94, 2005.
DOI : 10.1016/j.surg.2005.09.031

E. P. Slater, Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors, European Journal of Endocrinology, vol.154, issue.4, pp.587-98, 2006.
DOI : 10.1530/eje.1.02116

G. G. Fernandez-ranvier, Identification of biomarkers of adrenocortical carcinoma using 566

Z. Tömböl, Integrative molecular bioinformatics study of human adrenocortical tumors, p.569

P. S. Soon, Microarray gene expression and immunohistochemistry analyses of adrenocortical tumors identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomas, Endocrine Related Cancer, vol.16, issue.2, pp.573-583, 2009.
DOI : 10.1677/ERC-08-0237

C. Laurell, Transcriptional profiling enables molecular classification of adrenocortical tumours, European Journal of Endocrinology, vol.161, issue.1, pp.141-152, 2009.
DOI : 10.1530/EJE-09-0068

C. Gicquel, Rearrangements at the 11p15 locus and overexpression of insulin-like growth 577 factor-II gene in sporadic adrenocortical tumors, J. Clin. Endocrinol. Metab, vol.78, pp.1444-53, 1994.

F. M. Barlaskar, Preclinical Targeting of the Type 1 Insulin-like Growth Factor Receptor, p.579

E. E. Patterson, A. K. Holloway, J. Weng, T. Fojo, and E. Kebebew, MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy, Cancer, vol.70, issue.8, pp.1630-1639, 2011.
DOI : 10.1002/cncr.25724

P. S. Soon, miR-195 and miR-483-5p Identified as Predictors of Poor Prognosis, p.584

O. Chabre, Serum miR-483-5p and miR-195 are predictive of recurrence risk in 586 adrenocortical cancer patients, Endocr. Relat. Cancer, vol.20, pp.579-594, 2013.

D. M. Özata, The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma, Endocrine Related Cancer, vol.18, issue.6, pp.643-655, 2011.
DOI : 10.1530/ERC-11-0082

K. J. Schmitz, Differential expression of microRNA-675, microRNA-139-3p and microRNA- 590

N. S. Rechache, DNA Methylation Profiling Identifies Global Methylation Differences and Markers of Adrenocortical Tumors, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.6, pp.1004-1013, 2012.
DOI : 10.1210/jc.2011-3298

M. Kulis and M. Esteller, DNA Methylation and Cancer, Adv. Genet, vol.70, pp.27-56, 2010.
DOI : 10.1016/B978-0-12-380866-0.60002-2

O. Barreau, Identification of a CpG Island Methylator Phenotype in Adrenocortical 595

E. A. Stephan, Adrenocortical carcinoma survival rates correlated to genomic copy number variants, Molecular Cancer Therapeutics, vol.7, issue.2, pp.425-431, 2008.
DOI : 10.1158/1535-7163.MCT-07-0267

P. M. Szabó, Meta-analysis of adrenocortical tumour genomics data: novel pathogenic pathways revealed, Oncogene, vol.155, issue.21, pp.3163-3172, 2010.
DOI : 10.1038/onc.2010.80

O. Barreau, Clinical and Pathophysiological Implications of Chromosomal Alterations in Adrenocortical Tumors: An Integrated Genomic Approach, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.2, pp.301-311, 2012.
DOI : 10.1210/jc.2011-1588

C. L. Ronchi, Single nucleotide polymorphism array profiling of adrenocortical tumors

T. J. Giordano, Molecular Classification and Prognostication of Adrenocortical Tumors by 606

M. Toyota, CpG island methylator phenotype in colorectal cancer, Proc. Natl. Acad. Sci. U. 608 S. A. 96, pp.8681-8686, 1999.
DOI : 10.1073/pnas.96.15.8681

F. Tissier, Adrenocortical Tumors, The American Journal of Surgical Pathology, vol.36, issue.8, pp.36-1194, 2012.
DOI : 10.1097/PAS.0b013e31825a6308
URL : https://hal.archives-ouvertes.fr/inserm-00349152

A. Viola, Diagnosis and Treatment of Unilateral Forms of Primary Aldosteronism, Current Hypertension Reviews, vol.9, issue.2, p.613
DOI : 10.2174/15734021113099990008

S. Gaujoux, Wnt/??-Catenin and 3???,5???-Cyclic Adenosine 5???-Monophosphate/Protein Kinase A Signaling Pathways Alterations and Somatic ??-Catenin Gene Mutations in the Progression of Adrenocortical Tumors, The Journal of Clinical Endocrinology & Metabolism, vol.93, issue.10, pp.4135-4140, 2008.
DOI : 10.1210/jc.2008-0631

U. Elbelt, Molecular and clinical evidence for an ARMC5 tumor syndrome, p.618

M. Bisceglia, Oncocytic Adrenocortical Tumors, Pathology Case Reviews, vol.10, issue.5, pp.231-243, 2004.
DOI : 10.1097/01.pcr.0000175102.22075.54

M. C. Fragoso, Combined expression of BUB1B, DLGAP5, and PINK1 as predictors of poor outcome in adrenocortical tumors: validation in a Brazilian cohort of adult and pediatric patients, European Journal of Endocrinology, vol.166, issue.1, pp.61-67, 2012.
DOI : 10.1530/EJE-11-0806

L. A. Diaz and A. Bardelli, Liquid Biopsies: Genotyping Circulating Tumor DNA, Journal of Clinical Oncology, vol.32, issue.6, p.626
DOI : 10.1200/JCO.2012.45.2011

A. Sebio, M. Kahn, and H. Lenz, The potential of targeting Wnt/??-catenin in colon cancer, Expert Opinion on Therapeutic Targets, vol.162, issue.6
DOI : 10.1517/14728222.2014.906580

A. R. Glover, microRNA-7 as a tumor suppressor and novel therapeutic for adrenocortical 630 carcinoma, Oncotarget, pp.10-18632, 2015.

R. P. Lifton, A chimaeric ll??-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension, Nature, vol.355, issue.6357, pp.262-267, 1992.
DOI : 10.1038/355262a0

L. S. Kirschner, Mutations of the gene encoding the protein kinase A type I-alpha regulatory 634 subunit in patients with the Carney complex, Nat. Genet, vol.26, pp.89-92, 2000.

T. Wang, Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands, European Journal of Endocrinology, vol.164, issue.4, pp.613-619, 2011.
DOI : 10.1530/EJE-10-1085

E. A. Azizan, Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing 663

S. Monticone, Effect of KCNJ5 mutations on gene expression in aldosterone-producing 666

A. L. Fonseca, Comprehensive DNA methylation analysis of benign and malignant adrenocortical tumors, Genes, Chromosomes and Cancer, vol.17, issue.10, pp.949-960, 2012.
DOI : 10.1002/gcc.21978

B. Howard, in Aldosteronomas, The Journal of Clinical Endocrinology & Metabolism, vol.99, issue.3, pp.536-543, 2014.
DOI : 10.1210/jc.2013-3495

M. Murakami, Integration of transcriptome and methylome analysis of aldosterone-producing adenomas, European Journal of Endocrinology, vol.173, issue.2, pp.185-195, 2015.
DOI : 10.1530/EJE-15-0148

A. R. Glover, Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence, Endocrine Related Cancer, vol.22, issue.1, pp.99-109, 2015.
DOI : 10.1530/ERC-14-0457

D. R. Szabó, Analysis of circulating microRNAs in adrenocortical tumors, Laboratory Investigation, vol.28, issue.3, p.677
DOI : 10.1016/S0002-9440(10)63846-1

D. Patel, MiR-34a and miR-483-5p are candidate serum biomarkers for adrenocortical tumors, Surgery, vol.154, issue.6, pp.1224-1228, 2013.
DOI : 10.1016/j.surg.2013.06.022

S. Robertson, MicroRNA-24 Is a Novel Regulator of Aldosterone and Cortisol Production in the Human Adrenal Cortex, Hypertension, vol.62, issue.3, pp.572-578, 2013.
DOI : 10.1161/HYPERTENSIONAHA.113.01102

D. Velázquez-fernández, MicroRNA expression patterns associated with hyperfunctioning 683 and non-hyperfunctioning phenotypes in adrenocortical adenomas, Eur. J. Endocrinol. Eur. Fed, p.684

C. L. Ronchi, Single nucleotide polymorphism microarray analysis in cortisol-secreting 686