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Aminobisphosphonates inhibit dendritic cell-mediated antigen-specific activation of CD1d-restricted iNKT cells ☆ , ☆☆

Abstract : CD1d-restricted invariant natural killer T (iNKT) cells constitute an important immunoregulatory T cell subset that can be activated by the synthetic glycolipid α-galactosylceramide (α-GalCer) and initiate antitumor immune responses. As cancer patients are frequently treated with aminobisphosphonates (NBP), it is relevant to determine possible effects of NBP on CD1d-restricted glycolipid Ag-presentation to iNKT cells. We report a striking reduction of α-GalCer-induced iNKT cell activation by monocyte derived dendritic cells (moDC) upon their exposure to NBP during maturation. We found that production of apolipoprotein E (apoE), which is a known facilitator of trans-membrane transport of exogenously derived glycolipids, was significantly diminished in moDC exposed to NBP. As the inhibitory effect of NBP on iNKT cell activation was alleviated by exogenous apoE, our data indicate that reduced
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https://www.hal.inserm.fr/inserm-01280781
Contributor : Elizabeth Bernardo <>
Submitted on : Tuesday, March 1, 2016 - 10:33:53 AM
Last modification on : Friday, September 4, 2020 - 2:16:39 PM

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Famke Schneiders, Charlotte Huijts, Aslihan Mantici, Mica Menks, Emmanuel Scotet, et al.. Aminobisphosphonates inhibit dendritic cell-mediated antigen-specific activation of CD1d-restricted iNKT cells ☆ , ☆☆. Clinical Immunology, Elsevier, 2015, 158 (92-99), ⟨10.1016/j.clim.2015.03.007⟩. ⟨inserm-01280781⟩

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