Skip to Main content Skip to Navigation
Journal articles

The stress protein TP53INP1 plays a tumor suppressive role by regulating metabolic homeostasis

Abstract : In the recent years, we have provided evidence that Tumor Protein 53-Induced Nuclear Protein 1 (TP53INP1) is a key stress protein with antioxidant-associated tumor suppressive function. The TP53INP1 gene, which is highly conserved in mammals, is over-expressed during stress responses including inflammation. This gene encodes two protein isoforms with nuclear or cytoplasmic subcellular locali-zation depending on the context. TP53INP1 contributes to stress responses, thus preventing stress-induced dysfunctions leading to pathologies such as cancer. Two major mechanisms by which TP53INP1 functions have been unveiled. First, in the nucleus, TP53INP1 was shown to regulate the transcriptional activity of p53 and p73 by direct interaction, and to mediate the antioxidant activity of p53. Second, independently of p53, TP53INP1 contributes to autophagy and more particularly mitophagy through direct interaction with molecular actors of autophagy. TP53INP1 is thus required for the ho-meostasis of the mitochondrial compartment, and is therefore involved in the regulation of energetic metabolism. Finally, the antioxidant function of TP53INP1 stems from the control of mitochondrial reactive oxygen species production. In conclusion, TP53INP1 is a multifaceted protein endowed with multiple functions, including metabolic regulation, as is its main functional partner p53.
Document type :
Journal articles
Complete list of metadatas

Cited literature [102 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01270301
Contributor : Alice Carrier <>
Submitted on : Saturday, February 6, 2016 - 6:29:01 PM
Last modification on : Monday, September 23, 2019 - 3:32:04 PM
Long-term archiving on: : Saturday, November 12, 2016 - 11:56:16 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Houda Saadi, Marion Seillier, Alice Carrier. The stress protein TP53INP1 plays a tumor suppressive role by regulating metabolic homeostasis. Biochimie, Elsevier, 2015, 118, pp.44-50. ⟨10.1016/j.biochi.2015.07.024⟩. ⟨inserm-01270301⟩

Share

Metrics

Record views

189