Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice

Anne Gomez-Brouchet 1 Nelly Blaes 2 Lionel Mouledous 3 Olivier Fourcade 4 Ivan Tack 2 Bernard Francès 5 Jean-Pierre Girolami 2 Vincent Minville 4, 2, *
* Auteur correspondant
1 Service d’Anatomie Pathologique et Histologie ‑ Cytologie
2 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
3 IPBS - Institut de pharmacologie et de biologie structurale
4 Service d'Anesthésie - Réanimation
5 CRCA - Centre de Recherches sur la Cognition Animale
Abstract : AbstractBackgroundDiabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid induced hyperalgesia in diabetic and non-diabetic mice.MethodsDiabetic and non-diabetic mice underwent plantar surgery. Levobupivacaine and sufentanil were used before surgery, for sciatic nerve block (regional anaesthesia) and analgesia, respectively. Diabetic and non-diabetic groups were each randomly assigned to three subgroups: control, no sufentanil and no levobupivacaine; sufentanil and no levobupivacaine; sufentanil and levobupivacaine. Three tests were used to assess pain behaviour: mechanical nociception; thermal nociception and guarding behaviours using a pain scale.ResultsSufentanil, alone or in combination with levobupivacaine, produced antinociceptive effects shortly after administration. Subsequently, sufentanil induced hyperalgesia in diabetic and non-diabetic mice. Opioid-induced hyperalgesia was enhanced in diabetic mice. Levobupivacaine associated to sufentanil completely prevented hyperalgesia in both groups of mice.ConclusionThe results suggest that regional anaesthesia can decrease opioid-induced hyperalgesia in diabetic as well as in non-diabetic mice. These observations may be clinically relevant for the management of diabetic patients.
Keywords : Pain Plantar incision Regional anaesthesia Diabetes Levobupivacaine Naloxone Opioid induced hyperalgesia Sufentanil
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Article dans une revue
Journal of Translational Medicine, BioMed Central, 2015, 13 (1), pp.208. 〈10.1186/s12967-015-0575-0〉
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Anne Gomez-Brouchet, Nelly Blaes, Lionel Mouledous, Olivier Fourcade, Ivan Tack, et al.. Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice. Journal of Translational Medicine, BioMed Central, 2015, 13 (1), pp.208. 〈10.1186/s12967-015-0575-0〉. 〈inserm-01264509〉

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