Skip to Main content Skip to Navigation
Journal articles

Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice

Abstract : AbstractBackgroundDiabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid induced hyperalgesia in diabetic and non-diabetic mice.MethodsDiabetic and non-diabetic mice underwent plantar surgery. Levobupivacaine and sufentanil were used before surgery, for sciatic nerve block (regional anaesthesia) and analgesia, respectively. Diabetic and non-diabetic groups were each randomly assigned to three subgroups: control, no sufentanil and no levobupivacaine; sufentanil and no levobupivacaine; sufentanil and levobupivacaine. Three tests were used to assess pain behaviour: mechanical nociception; thermal nociception and guarding behaviours using a pain scale.ResultsSufentanil, alone or in combination with levobupivacaine, produced antinociceptive effects shortly after administration. Subsequently, sufentanil induced hyperalgesia in diabetic and non-diabetic mice. Opioid-induced hyperalgesia was enhanced in diabetic mice. Levobupivacaine associated to sufentanil completely prevented hyperalgesia in both groups of mice.ConclusionThe results suggest that regional anaesthesia can decrease opioid-induced hyperalgesia in diabetic as well as in non-diabetic mice. These observations may be clinically relevant for the management of diabetic patients.
Document type :
Journal articles
Complete list of metadatas

Cited literature [8 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01264509
Contributor : Bmc Bmc <>
Submitted on : Friday, January 29, 2016 - 12:43:33 PM
Last modification on : Thursday, September 10, 2020 - 3:08:09 PM
Long-term archiving on: : Friday, November 11, 2016 - 8:04:46 PM

File

12967_2015_Article_575.pdf
Publication funded by an institution

Identifiers

Collections

Citation

Anne Gomez-Brouchet, Nelly Blaes, Lionel Mouledous, Olivier Fourcade, Ivan Tack, et al.. Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice. Journal of Translational Medicine, BioMed Central, 2015, 13 (1), pp.208. ⟨10.1186/s12967-015-0575-0⟩. ⟨inserm-01264509⟩

Share

Metrics

Record views

197

Files downloads

329