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Journal articles
Early objective response may not be a prognostic factor of survival for patients with metastatic urothelial carcinoma: from a retrospective analysis of a cohort of 113 patients
Abstract : Background: This study aims to better define prognostic factors for patients with metastatic urothelial carcinoma (mUC), and to identify patients who will benefit from first-line cisplatin-based chemotherapy. We test the hypothesis that early objective response (EOR), defined as the occurrence of an objective response following 2 or 3 courses of chemotherapy, could be a prognostic factor for overall survival (OS) and thus be used to guide treatment decisions. Data from 113 patients with evaluable mUC receiving first-line cisplatin-based treatment between January 2004 and December 2006 was collected retrospectively from prospectively-maintained databases across seven French cancer centers. Clinical factors potentially associated with survival and EOR were analyzed in univariate and multivariate analysis. Results: One hundred three patient records were complete and available for inclusion in the multivariate model. Four factors were independently associated with OS: Performance status 1 and 2 (HR 2.3 [95 % CI 1.3–3.9], p = 0.002; HR 3.4 [95 % CI 1.6–7.2], p = 0.001 respectively); presence of visceral metastases (HR 2.2 [95 % CI 1.3–3.9], p = 0.004); abnormal hemoglobin levels (HR 1.7 [95 % CI 1.01–2.8], p = 0.045); disease progression (HR 10.1 [95 % CI 4.2–24.1], p < 0.001).
Cited literature [24 references]
https://www.hal.inserm.fr/inserm-01264496
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Submitted on : Friday, January 29, 2016 - 12:42:58 PM
Last modification on : Friday, December 3, 2021 - 12:12:56 PM
Long-term archiving on: : Friday, November 11, 2016 - 8:40:56 PM
Contributor : Bmc Bmc Connect in order to contact the contributor
Submitted on : Friday, January 29, 2016 - 12:42:58 PM
Last modification on : Friday, December 3, 2021 - 12:12:56 PM
Long-term archiving on: : Friday, November 11, 2016 - 8:40:56 PM
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