R. Kannaiyan, M. Shanmugam, and G. Sethi, Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer, Cancer Letters, vol.303, issue.1, pp.9-20, 2011.
DOI : 10.1016/j.canlet.2010.10.025

C. Mi, H. Shi, J. Ma, L. Han, J. Lee et al., Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9, Oncology Reports, vol.32, issue.6, pp.2527-2559, 2014.
DOI : 10.3892/or.2014.3535

J. Kim, J. Lee, S. Lee, N. Kim, G. You et al., Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53???polo like kinase 2 (PLK-2) pathway, Cellular Signalling, vol.25, issue.4, pp.805-818, 2013.
DOI : 10.1016/j.cellsig.2012.12.005

H. Yang, D. Chen, Q. Cui, X. Yuan, and Q. Dou, Celastrol, a Triterpene Extracted from the Chinese "Thunder of God Vine," Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice, Cancer Research, vol.66, issue.9, pp.4758-65, 2006.
DOI : 10.1158/0008-5472.CAN-05-4529

Z. Liu, L. Ma, Z. Wen, Z. Hu, F. Wu et al., Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer, Carcinogenesis, vol.35, issue.4, pp.905-919, 2014.
DOI : 10.1093/carcin/bgt395

P. Rajendran, F. Li, M. Shanmugam, R. Kannaiyan, J. Goh et al., Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo, Cancer Prevention Research, vol.5, issue.4, pp.631-674, 2012.
DOI : 10.1158/1940-6207.CAPR-11-0420

M. Sha, J. Ye, L. Zhang, Z. Luan, Y. Chen et al., Celastrol Induces Apoptosis of Gastric Cancer Cells by miR-21 Inhibiting PI3K/Akt-NF-??B Signaling Pathway, Pharmacology, vol.93, issue.1-2, pp.39-46, 2014.
DOI : 10.1159/000357683

S. Abbas, A. Bhoumik, R. Dahl, S. Vasile, S. Krajewski et al., Preclinical Studies of Celastrol and Acetyl Isogambogic Acid in Melanoma, Clinical Cancer Research, vol.13, issue.22, pp.6769-78, 2007.
DOI : 10.1158/1078-0432.CCR-07-1536

B. Peng, L. Xu, F. Cao, T. Wei, C. Yang et al., HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way, Molecular Cancer, vol.9, issue.1, p.79, 2010.
DOI : 10.1186/1476-4598-9-79

URL : https://hal.archives-ouvertes.fr/inserm-00668221

S. Westerheide, J. Bosman, B. Mbadugha, T. Kawahara, G. Matsumoto et al., Celastrols as Inducers of the Heat Shock Response and Cytoprotection, Journal of Biological Chemistry, vol.279, issue.53, pp.56053-60, 2004.
DOI : 10.1074/jbc.M409267200

M. Matokanovic, K. Barisic, J. Filipovic-grcic, and D. Maysinger, Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90, European Journal of Pharmaceutical Sciences, vol.50, issue.1, pp.149-58, 2013.
DOI : 10.1016/j.ejps.2013.04.001

B. Peng, X. Zhang, F. Cao, Y. Wang, L. Xu et al., Peptide deformylase inhibitor actinonin reduces celastrol???s HSP70 induction while synergizing proliferation inhibition in tumor cells, BMC Cancer, vol.13, issue.2, p.146, 2014.
DOI : 10.1186/1471-2407-13-321

M. Haneklaus, M. Gerlic, O. Neill, L. Masters, and S. , miR-223: infection, inflammation and cancer, Journal of Internal Medicine, vol.38, issue.3, pp.215-241, 2013.
DOI : 10.1111/joim.12099

M. Yang, J. Chen, F. Su, Y. B. Su, F. Lin et al., Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells, Molecular Cancer, vol.10, issue.1, p.117, 2011.
DOI : 10.1186/1471-2172-3-7

E. Pinatel, F. Orso, E. Penna, D. Cimino, A. Elia et al., miR-223 Is a Coordinator of Breast Cancer Progression as Revealed by Bioinformatics Predictions, PLoS ONE, vol.32, issue.1, p.84859, 2014.
DOI : 10.1371/journal.pone.0084859.s004

Y. Wei, Y. J. Yi, L. Wang, Y. Dong, Z. Liu et al., MiR-223-3p targeting SEPT6 promotes the biological behavior of prostate cancer, Scientific Reports, vol.25, p.7546, 2014.
DOI : 10.1038/srep07546

L. Ma, Y. Chen, B. Zhang, and G. Liu, -associated gastric cancer contributed to cancer cell proliferation and migration, Bioscience, Biotechnology, and Biochemistry, vol.3, issue.294, pp.602-610, 2014.
DOI : 10.1016/j.bbrc.2009.12.182

URL : https://hal.archives-ouvertes.fr/hal-00018610

J. Zhang, X. Luo, H. Li, X. Yue, L. Deng et al., MicroRNA-223 functions as an oncogene in human colorectal cancer cells, Oncology Reports, vol.32, issue.1, pp.115-135, 2014.
DOI : 10.3892/or.2014.3173

Y. Kim, H. Kang, S. Jang, and J. Ko, Celastrol Inhibits Breast Cancer Cell Invasion via Suppression of NF-??B-mediated Matrix Metalloproteinase-9 Expression, Cellular Physiology and Biochemistry, vol.28, issue.2, pp.175-84, 2011.
DOI : 10.1159/000331729

N. Nam, Naturally Occurring NF-κB Inhibitors, Mini-Reviews in Medicinal Chemistry, vol.6, issue.8, pp.945-51, 2006.
DOI : 10.2174/138955706777934937

K. Chiang, K. Tsui, L. Chung, C. Yeh, W. Chen et al., Celastrol Blocks Interleukin-6 Gene Expression via Downregulation of NF-??B in Prostate Carcinoma Cells, PLoS ONE, vol.385, issue.3, p.93151, 2014.
DOI : 10.1371/journal.pone.0093151.g006

V. Kumar, R. Palermo, C. Talora, A. Campese, S. Checquolo et al., Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia, Leukemia, vol.204, issue.12, pp.2324-2359, 2014.
DOI : 10.1038/leu.2014.133

J. Lee, Y. Won, K. Park, M. Lee, H. Tachibana et al., Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling, Apoptosis, vol.557, issue.12, pp.1275-86, 2012.
DOI : 10.1007/s10495-012-0767-5

G. Sethi, K. Ahn, M. Pandey, and B. Aggarwal, Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation, Blood, vol.109, issue.7, pp.2727-2762, 2007.

S. Boridy, P. Le, K. Petrecca, and D. Maysinger, Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells, Cell Death and Disease, vol.56, issue.5, p.1216, 2014.
DOI : 10.1002/stem.98

X. Pang, Z. Yi, J. Zhang, B. Lu, B. Sung et al., Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway, Cancer Research, vol.70, issue.5, pp.1951-1960, 2010.
DOI : 10.1158/0008-5472.CAN-09-3201

H. Bao, H. Chen, X. Zhu, M. Zhang, G. Yao et al., MiR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin ??4 and ??5 in IgA nephropathy, Kidney International, vol.85, issue.3, pp.624-659, 2014.
DOI : 10.1038/ki.2013.469

G. Li, M. Cai, D. Fu, K. Chen, M. Sun et al., Heat Shock Protein 90B1 Plays an Oncogenic Role and is a Target of microRNA-223 in Human Osteosarcoma, Cellular Physiology and Biochemistry, vol.30, issue.6, pp.1481-90, 2012.
DOI : 10.1159/000343336

C. Jia, H. Li, X. Zhu, Y. Dong, D. Fu et al., MiR-223 Suppresses Cell Proliferation by Targeting IGF-1R, PLoS ONE, vol.405, issue.11, p.27008, 2011.
DOI : 10.1371/journal.pone.0027008.g009

D. Zhang, A. Marconi, L. Xu, C. Yang, G. Sun et al., Tripterine inhibits the expression of adhesion molecules in activated endothelial cells, Journal of Leukocyte Biology, vol.80, issue.2, pp.309-328, 2006.
DOI : 10.1189/jlb.1005611

URL : https://hal.archives-ouvertes.fr/inserm-00180304

G. Yang, H. Feng, and Y. Li, Di-and Triterpenoids from Tripterygium wilfordii, Natural Product Letters, vol.46, issue.2, pp.103-113, 2001.
DOI : 10.1021/np9902183

G. Harrison, A. Bennett, M. Moody, G. Read, and P. Williams, Use of formalinfixed , propidium iodide-stained human leukocytes as a standard for enumerating CD4+ T lymphocytes in a single-platform assay, Clin Diagn Lab Immunol, vol.8, issue.2, pp.397-401, 2001.

F. Cao, L. Xu, B. Peng, Q. Xie, G. Uzan et al., A routinely applicable way for using FCM in cell enumeration with CFSE-labeled Cell Beads as internal standard, Cytometry A, vol.75, issue.12, pp.975-983, 2009.

H. Li, Y. Li, D. Liu, H. Sun, and J. Liu, miR-224 is Critical for Celastrol-Induced Inhibition of Migration and Invasion of Hepatocellular Carcinoma Cells, Cellular Physiology and Biochemistry, vol.32, issue.2, pp.448-58, 2013.
DOI : 10.1159/000354450

K. Vickers, S. Landstreet, M. Levin, B. Shoucri, C. Toth et al., MicroRNA-223 coordinates cholesterol homeostasis, Proceedings of the National Academy of Sciences, vol.111, issue.40, pp.14518-14541, 2014.
DOI : 10.1073/pnas.1215767111

H. Lu, R. Buchan, and S. Cook, MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism, Cardiovascular Research, vol.86, issue.3, pp.410-430, 2010.
DOI : 10.1093/cvr/cvq010

Z. Yang, L. Zhong, R. Xian, and B. Yuan, MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage, Molecular Immunology, vol.65, issue.2, pp.267-76, 2015.
DOI : 10.1016/j.molimm.2014.12.018

A. Dorhoi, M. Iannaccone, M. Farinacci, K. Fae, J. Schreiber et al., MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment, Journal of Clinical Investigation, vol.123, issue.11, pp.4836-4884, 2013.
DOI : 10.1172/JCI67604DS1

J. Yang, J. Li, S. Jiang, H. Zhou, and L. Qu, ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data, Nucleic Acids Research, vol.41, issue.D1, pp.177-187, 2013.
DOI : 10.1093/nar/gks1060