Skip to Main content Skip to Navigation
Journal articles

Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial

Abstract : Purpose Few data are available regarding the relation of left ventricular (LV) mechanical dyssynchrony to remodelling after acute myocardial infarction (MI) and stem cell therapy. We evaluated the 1-year time course of both LV mechanical dyssynchrony and remodelling in patients enrolled in the BONAMI trial, a randomized, multicenter controlled trial assessing cell therapy in patients with reperfused MI. Methods Patients with acute MI and ejection fraction (EF) ≤ 45 % were randomized to cell therapy or to control and underwent thallium single-photon emission computed to-mography (SPECT), radionuclide angiography, and echocar-diography at baseline, 3 months, and 1 year. Eighty-three patients with a comprehensive 1-year follow-up were included. LV dyssynchrony was assessed by the standard deviation (SD) of the LV phase histogram using radionuclide angiography. Electronic supplementary material The online version of this article (doi:10.1007/s00259-015-3279-z) contains supplementary material, which is available to authorized users.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-01261620
Contributor : Patricia Lemarchand <>
Submitted on : Wednesday, February 3, 2016 - 9:53:01 AM
Last modification on : Wednesday, August 19, 2020 - 11:17:11 AM
Long-term archiving on: : Saturday, November 12, 2016 - 4:48:46 AM

Files

38. Bonami REMOD soumis 20 OCT...
Files produced by the author(s)

Identifiers

Citation

Alain Manrique, Patricia Lemarchand, Béatrice Delasalle, Olivier Lairez, Catherine Sportouch-Duckan, et al.. Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial. European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2015, ⟨10.1007/s00259-015-3279-z⟩. ⟨inserm-01261620⟩

Share

Metrics

Record views

373

Files downloads

452