Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial

Abstract : Purpose Few data are available regarding the relation of left ventricular (LV) mechanical dyssynchrony to remodelling after acute myocardial infarction (MI) and stem cell therapy. We evaluated the 1-year time course of both LV mechanical dyssynchrony and remodelling in patients enrolled in the BONAMI trial, a randomized, multicenter controlled trial assessing cell therapy in patients with reperfused MI. Methods Patients with acute MI and ejection fraction (EF) ≤ 45 % were randomized to cell therapy or to control and underwent thallium single-photon emission computed to-mography (SPECT), radionuclide angiography, and echocar-diography at baseline, 3 months, and 1 year. Eighty-three patients with a comprehensive 1-year follow-up were included. LV dyssynchrony was assessed by the standard deviation (SD) of the LV phase histogram using radionuclide angiography. Electronic supplementary material The online version of this article (doi:10.1007/s00259-015-3279-z) contains supplementary material, which is available to authorized users.
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Article dans une revue
European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2015, 〈10.1007/s00259-015-3279-z〉
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http://www.hal.inserm.fr/inserm-01261620
Contributeur : Patricia Lemarchand <>
Soumis le : mercredi 3 février 2016 - 09:53:01
Dernière modification le : jeudi 13 septembre 2018 - 10:50:02
Document(s) archivé(s) le : samedi 12 novembre 2016 - 04:48:46

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Alain Manrique, Patricia Lemarchand, Béatrice Delasalle, Olivier Lairez, Catherine Sportouch-Duckan, et al.. Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial. European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2015, 〈10.1007/s00259-015-3279-z〉. 〈inserm-01261620〉

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