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Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial

Abstract : Purpose Few data are available regarding the relation of left ventricular (LV) mechanical dyssynchrony to remodelling after acute myocardial infarction (MI) and stem cell therapy. We evaluated the 1-year time course of both LV mechanical dyssynchrony and remodelling in patients enrolled in the BONAMI trial, a randomized, multicenter controlled trial assessing cell therapy in patients with reperfused MI. Methods Patients with acute MI and ejection fraction (EF) ≤ 45 % were randomized to cell therapy or to control and underwent thallium single-photon emission computed to-mography (SPECT), radionuclide angiography, and echocar-diography at baseline, 3 months, and 1 year. Eighty-three patients with a comprehensive 1-year follow-up were included. LV dyssynchrony was assessed by the standard deviation (SD) of the LV phase histogram using radionuclide angiography. Electronic supplementary material The online version of this article (doi:10.1007/s00259-015-3279-z) contains supplementary material, which is available to authorized users.
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https://www.hal.inserm.fr/inserm-01261620
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Submitted on : Wednesday, February 3, 2016 - 9:53:01 AM
Last modification on : Wednesday, December 2, 2020 - 3:18:02 PM
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Alain Manrique, Patricia Lemarchand, Béatrice Delasalle, Olivier Lairez, Catherine Sportouch, et al.. Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial. European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2015, ⟨10.1007/s00259-015-3279-z⟩. ⟨inserm-01261620⟩

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