. Epcam, Epithelial cell adhesion molecule; FGF: Fibroblast growth factor

U. Puppi, J. Hughes, R. Mitry, and R. , Human hepatocyte transplantation: current experience and future challenges, Nat Rev Gastroenterol Hepatol, vol.7, issue.5, pp.288-98, 2010.

J. Puppi, S. Strom, R. Hughes, S. Bansal, J. Castell et al., Improving the Techniques for Human Hepatocyte Transplantation: Report From a Consensus Meeting in London, Cell Transplantation, vol.21, issue.1, pp.1-10, 2012.
DOI : 10.3727/096368911X566208

R. Hughes, R. Mitry, and A. Dhawan, Current Status of Hepatocyte Transplantation, Transplantation, vol.93, issue.4, pp.342-349, 2012.
DOI : 10.1097/TP.0b013e31823b72d6

S. Schwartz, C. Regillo, B. Lam, D. Eliott, P. Rosenfeld et al., Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies, The Lancet, vol.385, issue.9967, pp.509-525, 2015.
DOI : 10.1016/S0140-6736(14)61376-3

F. Lemaigre, Mechanisms of Liver Development: Concepts for Understanding Liver Disorders and Design of Novel Therapies, Gastroenterology, vol.137, issue.1, pp.62-79, 2009.
DOI : 10.1053/j.gastro.2009.03.035

K. Zaret and J. Carroll, Pioneer transcription factors: establishing competence for gene expression, Genes & Development, vol.25, issue.21, pp.2227-2268, 2011.
DOI : 10.1101/gad.176826.111

L. Vallier, T. Touboul, Z. Chng, M. Brimpari, N. Hannan et al., Early Cell Fate Decisions of Human Embryonic Stem Cells and Mouse Epiblast Stem Cells Are Controlled by the Same Signalling Pathways, PLoS ONE, vol.4, issue.6, 2009.
DOI : 10.1371/journal.pone.0006082.t002

D. Amour, K. Agulnick, A. Eliazer, S. Kelly, O. Kroon et al., Efficient differentiation of human embryonic stem cells to definitive endoderm, Nature Biotechnology, vol.132, issue.12, pp.1534-1575, 1163.
DOI : 10.1038/nbt1163

Y. Duan, A. Catana, Y. Meng, N. Yamamoto, S. He et al., Differentiation and Enrichment of Hepatocyte-Like Cells from Human Embryonic Stem Cells In Vitro and In Vivo, Stem Cells, vol.17, issue.12, pp.3058-68, 2007.
DOI : 10.1634/stemcells.2007-0291

H. Basma, A. Soto-gutierrez, G. Yannam, L. Liu, R. Ito et al., Differentiation and Transplantation of Human Embryonic Stem Cell???Derived Hepatocytes, Gastroenterology, vol.136, issue.3, pp.990-999, 2009.
DOI : 10.1053/j.gastro.2008.10.047

J. Cai, Y. Zhao, Y. Liu, F. Ye, Z. Song et al., Directed differentiation of human embryonic stem cells into functional hepatic cells, Hepatology, vol.12, issue.5, pp.1229-1268, 2007.
DOI : 10.1002/hep.21582

D. Hay, J. Fletcher, C. Payne, J. Terrace, R. Gallagher et al., Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling, Proceedings of the National Academy of Sciences, vol.105, issue.34, pp.12301-12307, 2008.
DOI : 10.1073/pnas.0806522105

K. Si-tayeb, F. Noto, M. Nagaoka, J. Li, M. Battle et al., Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells, Hepatology, vol.26, issue.1, pp.297-305, 2010.
DOI : 10.1002/hep.23354

P. Roelandt, K. Pauwelyn, P. Sancho-bru, K. Subramanian, B. Bose et al., Human Embryonic and Rat Adult Stem Cells with Primitive Endoderm-Like Phenotype Can Be Fated to Definitive Endoderm, and Finally Hepatocyte-Like Cells, PLoS ONE, vol.72, issue.8, 2010.
DOI : 10.1371/journal.pone.0012101.s006

Y. Chen, C. Tseng, H. Wang, H. Kuo, V. Yang et al., Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol, Hepatology, vol.17, issue.4, pp.1193-203, 2012.
DOI : 10.1002/hep.24790

T. Touboul, N. Hannan, S. Corbineau, A. Martinez, C. Martinet et al., Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development, Hepatology, vol.5, issue.5, pp.1754-65, 2010.
DOI : 10.1002/hep.23506

S. Rashid, S. Corbineau, N. Hannan, S. Marciniak, E. Miranda et al., Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells, Journal of Clinical Investigation, vol.120, issue.9, pp.3127-3163, 2010.
DOI : 10.1172/JCI43122DS1

M. Baxter, S. Withey, S. Harrison, C. Segeritz, F. Zhang et al., Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes, Journal of Hepatology, vol.62, issue.3, pp.581-590, 2015.
DOI : 10.1016/j.jhep.2014.10.016

N. Hannan, C. Segeritz, T. Touboul, and L. Vallier, Production of hepatocyte-like cells from human pluripotent stem cells, Nature Protocols, vol.8, issue.2, pp.430-437, 2013.
DOI : 10.1002/stem.199

G. Yang, K. Si-tayeb, S. Corbineau, R. Vernet, R. Gayon et al., Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors, BMC Biology, vol.11, issue.1, pp.86-96, 2013.
DOI : 10.1073/pnas.062038599

URL : https://hal.archives-ouvertes.fr/inserm-00852086

H. Kubota, H. Yao, and L. Reid, Identification and Characterization of Vitamin A-Storing Cells in Fetal Liver: Implications for Functional Importance of Hepatic Stellate Cells in Liver Development and Hematopoiesis, STEM CELLS, vol.24, issue.9, pp.2339-2388, 2007.
DOI : 10.1634/stemcells.2006-0316

O. Lozoya, E. Wauthier, R. Turner, C. Barbier, G. Prestwich et al., Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche, Biomaterials, vol.32, issue.30, pp.7389-402, 2011.
DOI : 10.1016/j.biomaterials.2011.06.042

D. Haridass, Q. Yuan, P. Becker, T. Cantz, M. Iken et al., Repopulation Efficiencies of Adult Hepatocytes, Fetal Liver Progenitor Cells, and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice, The American Journal of Pathology, vol.175, issue.4, pp.1483-92, 2009.
DOI : 10.2353/ajpath.2009.090117

S. Asgari, M. Moslem, K. Bagheri-lankarani, B. Pournasr, M. Miryounesi et al., Differentiation and Transplantation of Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells, Stem Cell Reviews and Reports, vol.120, issue.4, pp.493-504
DOI : 10.1007/s12015-011-9330-y

H. Liu, Y. Kim, S. Sharkis, L. Marchionni, and Y. Jang, In Vivo Liver Regeneration Potential of Human Induced Pluripotent Stem Cells from Diverse Origins, Science Translational Medicine, vol.3, issue.82, 2011.
DOI : 10.1126/scitranslmed.3002376

D. Woo, S. Kim, H. Lim, J. Heo, H. Park et al., Direct and Indirect Contribution of Human Embryonic Stem Cell???Derived Hepatocyte-Like Cells to Liver Repair in Mice, Gastroenterology, vol.142, issue.3, pp.602-613, 2012.
DOI : 10.1053/j.gastro.2011.11.030

J. Delgado, V. Vanneaux, J. Branger, T. Touboul, L. Sentilhes et al., The role of HGF on invasive properties and repopulation potential of human fetal hepatic progenitor cells, Experimental Cell Research, vol.315, issue.19, pp.3396-405, 2009.
DOI : 10.1016/j.yexcr.2009.07.007

D. Mahieu-caputo, J. Allain, J. Branger, A. Coulomb, J. Delgado et al., Repopulation of Athymic Mouse Liver by Cryopreserved Early Human Fetal Hepatoblasts, Human Gene Therapy, vol.15, issue.12, pp.1219-1247, 2004.
DOI : 10.1089/hum.2004.15.1219

H. Malhi, A. Irani, S. Gagandeep, and S. Gupta, Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes, J Cell Sci, vol.115, pp.2679-88, 2002.

C. Aguilar-gallardo, M. Poo, E. Gomez, A. Galan, E. Sanchez et al., Derivation, characterization, differentiation, and registration of seven human embryonic stem cell lines (VAL-3, -4, -5, -6M, -7, -8, and -9) on human feeder, In Vitro Cellular & Developmental Biology - Animal, vol.17, issue.116???118, pp.3-4317, 2010.
DOI : 10.1007/s11626-010-9285-3

M. Donato, A. Lahoz, S. Montero, A. Bonora, E. Pareja et al., Functional Assessment of the Quality of Human Hepatocyte Preparations for Cell Transplantation, Cell Transplantation, vol.17, issue.10, pp.10-111211, 2008.
DOI : 10.3727/096368908787236620

M. Gomez-lechon, A. Lahoz, J. Castell, and M. Donato, Evaluation of Cytochrome P450 Activities in Human Hepatocytes In Vitro, Methods Mol Biol, vol.806, pp.87-97, 2012.
DOI : 10.1007/978-1-61779-367-7_7

M. Donato, S. Montero, J. Castell, M. Gomez-lechon, and A. Lahoz, Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies, Analytical and Bioanalytical Chemistry, vol.28, issue.1, pp.2251-63, 2010.
DOI : 10.1007/s00216-009-3441-1

N. Dianat, H. Dubois-pot-schneider, C. Steichen, C. Desterke, P. Leclerc et al., Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells, Hepatology, vol.58, issue.2, pp.700-714, 2014.
DOI : 10.1002/hep.27165

URL : https://hal.archives-ouvertes.fr/hal-01169803

C. Terry, A. Dhawan, R. Mitry, S. Lehec, and R. Hughes, Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation, Liver Transplantation, vol.16, issue.2, pp.229-266, 2010.
DOI : 10.1002/lt.21983

L. Tolosa, E. Pareja-ibars, M. Donato, M. Cortes, S. Lopez et al., Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation, Cell Transplantation, vol.23, issue.10, pp.1229-1271, 2014.
DOI : 10.3727/096368913X669743

P. Newsome, J. Plevris, L. Nelson, and P. Hayes, Animal models of fulminant hepatic failure: A critical evaluation, Liver Transplantation, vol.97, issue.1, 2000.
DOI : 10.1002/lt.500060110

Z. Farzaneh, B. Pournasr, M. Ebrahimi, N. Aghdami, and H. Baharvand, Enhanced Functions of Human Embryonic Stem Cell-derived Hepatocyte-like Cells on Three-dimensional Nanofibrillar Surfaces, Stem Cell Reviews and Reports, vol.331, issue.2, pp.601-611, 2010.
DOI : 10.1007/s12015-010-9179-5

Y. Yu, K. Kim, S. Lee, S. Choi, Y. Kim et al., Hepatic Differentiation from Human Embryonic Stem Cells Using Stromal Cells, Journal of Surgical Research, vol.170, issue.2, pp.253-61, 2011.
DOI : 10.1016/j.jss.2011.06.032

W. Liu, J. Ramirez, E. Gamazon, S. Mirkov, P. Chen et al., Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver, Human Molecular Genetics, vol.23, issue.20, pp.5558-69, 2014.
DOI : 10.1093/hmg/ddu268

R. Hines, The ontogeny of drug metabolism enzymes and implications for adverse drug events, Pharmacology & Therapeutics, vol.118, issue.2, pp.250-67, 2008.
DOI : 10.1016/j.pharmthera.2008.02.005

E. Schmelzer, L. Zhang, A. Bruce, E. Wauthier, J. Ludlow et al., Human hepatic stem cells from fetal and postnatal donors, The Journal of Experimental Medicine, vol.82, issue.8, pp.1973-87, 2007.
DOI : 10.1016/S0963-6897(98)00008-6

R. Turner, E. Wauthier, O. Lozoya, R. Mcclelland, J. Bowsher et al., Successful transplantation of human hepatic stem cells with restricted localization to liver using hyaluronan grafts???, Hepatology, vol.24, issue.9 Suppl., pp.775-84, 2013.
DOI : 10.1002/hep.26065

A. Carpentier, A. Tesfaye, V. Chu, I. Nimgaonkar, F. Zhang et al., Engrafted human stem cell???derived hepatocytes establish an infectious HCV murine model, Journal of Clinical Investigation, vol.124, issue.11, pp.4953-64, 2014.
DOI : 10.1172/JCI75456DS1

X. Song, Y. Guo, S. Duo, C. J. Wu, C. Ochiya et al., A Mouse Model of Inducible Liver Injury Caused by Tet-On Regulated Urokinase for Studies of Hepatocyte Transplantation, The American Journal of Pathology, vol.175, issue.5, pp.1975-83, 2009.
DOI : 10.2353/ajpath.2009.090349

N. Steinebrunner, C. Mogler, S. Vittas, B. Hoyler, C. Sandig et al., Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse, BMC Gastroenterology, vol.112, issue.1, pp.148-158, 2014.
DOI : 10.1097/ALN.0b013e3181c5388f

C. Ju, Damage-associated molecular patterns: Their impact on the liver and beyond during acetaminophen overdose, Hepatology, vol.247, issue.5, pp.1599-601, 2012.
DOI : 10.1002/hep.25920

W. Lee, A. Larson, and J. Arenas, Thinking through acetaminophen hepatotoxicity and liver transplantation: Choosing worthy recipients, Liver Transplantation, vol.329, issue.6, pp.567-576, 2009.
DOI : 10.1002/lt.21728

U. Ben-david and N. Benvenisty, The tumorigenicity of human embryonic and induced pluripotent stem cells, Nature Reviews Cancer, vol.471, issue.4, pp.268-77, 2011.
DOI : 10.1038/nrc3034

L. Cui, Y. Guan, Z. Qu, J. Zhang, B. Liao et al., WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors, Journal of Clinical Investigation, vol.123, issue.4, pp.1647-61, 2013.
DOI : 10.1172/JCI65048DS1

D. Doi, A. Morizane, T. Kikuchi, H. Onoe, T. Hayashi et al., Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC-Derived Neural Cells in a Primate Model of Parkinson's Disease, STEM CELLS, vol.107, issue.suppl 3, pp.935-980, 2012.
DOI : 10.1002/stem.1060

R. Chinzei, Y. Tanaka, K. Shimizu-saito, Y. Hara, S. Kakinuma et al., Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes, Hepatology, vol.97, issue.1, pp.22-31, 2002.
DOI : 10.1053/jhep.2002.34136

N. Amariglio, A. Hirshberg, B. Scheithauer, Y. Cohen, R. Loewenthal et al., Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient, PLoS Medicine, vol.302, issue.2, 2009.
DOI : 10.1371/journal.pmed.1000029.sd001

D. Cyranoski, Strange lesions after stem-cell therapy, Nature, vol.465, issue.7301, 2010.
DOI : 10.1038/465997a

J. Harding and O. Mirochnitchenko, Preclinical Studies for Induced Pluripotent Stem Cell-based Therapeutics, Journal of Biological Chemistry, vol.289, issue.8, pp.4585-93, 2014.
DOI : 10.1074/jbc.R113.463737

Y. Tan, S. Ooi, and L. Wang, Immunogenicity and Tumorigenicity of Pluripotent Stem Cells and their Derivatives: Genetic and Epigenetic Perspectives, Current Stem Cell Research & Therapy, vol.9, issue.1, pp.63-72, 2014.
DOI : 10.2174/1574888X113086660068

K. Chen, K. Pernelle, Y. Tsai, Y. Wu, J. Hsieh et al., Liver X receptor ?? (LXR??/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4??, Journal of Hepatology, vol.61, issue.6, pp.1276-86, 2014.
DOI : 10.1016/j.jhep.2014.07.025

E. Fitzpatrick, R. Mitry, and A. Dhawan, Human hepatocyte transplantation: state of the art, Journal of Internal Medicine, vol.52, issue.Suppl. 1, pp.339-57, 2009.
DOI : 10.1111/j.1365-2796.2009.02152.x

C. Selden and H. Hodgson, Cellular therapies for liver replacement, Transplant Immunology, vol.12, issue.3-4, pp.3-4273, 2004.
DOI : 10.1016/j.trim.2003.12.008

C. Ribes-koninckx, E. Ibars, C. Agrasot, M. Bonora-centelles, A. Miquel et al., Clinical Outcome of Hepatocyte Transplantation in Four Pediatric Patients With Inherited Metabolic Diseases, Cell Transplantation, vol.21, issue.10, pp.2267-82, 2012.
DOI : 10.3727/096368912X637505

G. Lanzoni, T. Oikawa, Y. Wang, C. Cui, G. Carpino et al., Concise review: Clinical programs of stem cell therapies for liver and pancreas, STEM CELLS, vol.499, issue.10, pp.2047-60, 2013.
DOI : 10.1002/stem.1457

V. Cardinale, G. Carpino, R. Gentile, C. Napoletano, H. Rahimi et al., Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis, BMC Gastroenterology, vol.18, issue.2, pp.204-214, 2014.
DOI : 10.1002/lt.22322

L. Li, M. Baroja, A. Majumdar, K. Chadwick, A. Rouleau et al., Human Embryonic Stem Cells Possess Immune-Privileged Properties, Stem Cells, vol.22, issue.4, pp.448-56, 2004.
DOI : 10.1634/stemcells.22-4-448

S. Bhatia, G. Underhill, K. Zaret, and I. Fox, Cell and tissue engineering for liver disease, Science Translational Medicine, vol.6, issue.245, pp.245-247, 2014.
DOI : 10.1126/scitranslmed.3005975

T. Takebe, K. Sekine, M. Enomura, H. Koike, M. Kimura et al., Vascularized and functional human liver from an iPSC-derived organ bud transplant, Nature, vol.51, issue.7459, pp.481-485, 2013.
DOI : 10.1073/pnas.1109767108