Y. Yang, Cancer immunotherapy: harnessing the immune system to battle cancer, Journal of Clinical Investigation, vol.125, issue.9, pp.3335-3342, 2015.
DOI : 10.1172/JCI83871

J. Joyce and D. Fearon, T cell exclusion, immune privilege, and the tumor microenvironment, Science, vol.348, issue.6230, pp.74-80, 2015.
DOI : 10.1126/science.aaa6204

C. Slaney, M. Kershaw, and P. Darcy, Trafficking of T Cells into Tumors, Cancer Research, vol.74, issue.24, pp.7168-74, 2014.
DOI : 10.1158/0008-5472.CAN-14-2458

P. Mrass, H. Takano, L. Ng, S. Daxini, M. Lasaro et al., Random migration precedes stable target cell interactions of tumor-infiltrating T cells, The Journal of Experimental Medicine, vol.70, issue.12, pp.2749-61, 2006.
DOI : 10.3109/10739689609148303

A. Boissonnas, L. Fetler, I. Zeelenberg, S. Hugues, and S. Amigorena, In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor, The Journal of Experimental Medicine, vol.115, issue.2, pp.345-56, 2007.
DOI : 10.1084/jem.20041378

B. Breart, F. Lemaitre, S. Celli, and P. Bousso, Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice, Journal of Clinical Investigation, vol.118, issue.4, pp.1390-1397, 2008.
DOI : 10.1172/JCI34388

A. Boissonnas, F. Licata, L. Poupel, J. S. Fetler, L. Krumeich et al., CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network, Neoplasia, vol.15, issue.1, pp.85-94, 2013.
DOI : 10.1593/neo.121572

M. Ruocco, K. Pilones, N. Kawashima, M. Cammer, J. Huang et al., Suppressing T cell motility induced by anti???CTLA-4 monotherapy improves antitumor effects, Journal of Clinical Investigation, vol.122, issue.10, pp.3718-3748, 2012.
DOI : 10.1172/JCI61931DS1

T. Pentcheva-hoang, T. Simpson, W. Montalvo-ortiz, and J. Allison, Cytotoxic T Lymphocyte Antigen-4 Blockade Enhances Antitumor Immunity by Stimulating Melanoma-Specific T-cell Motility, Cancer Immunology Research, vol.2, issue.10, pp.970-80, 2014.
DOI : 10.1158/2326-6066.CIR-14-0104

J. Engelhardt, B. Boldajipour, P. Beemiller, P. Pandurangi, C. Sorensen et al., Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells, Cancer Cell, vol.21, issue.3, pp.402-419, 2012.
DOI : 10.1016/j.ccr.2012.01.008

H. Salmon, K. Franciszkiewicz, D. Damotte, M. Dieu-nosjean, P. Validire et al., Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors, Journal of Clinical Investigation, vol.122, issue.3, pp.899-91010, 1172.
DOI : 10.1172/JCI45817DS1

Y. Naito, K. Saito, K. Shiiba, A. Ohuchi, K. Saigenji et al., CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer, Cancer Res, issue.16, pp.583491-583495, 1998.

L. Zhang, J. Conejo-garcia, D. Katsaros, P. Gimotty, M. Massobrio et al., Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer, New England Journal of Medicine, vol.348, issue.3, pp.203-216, 2003.
DOI : 10.1056/NEJMoa020177

E. Sato, S. Olson, J. Ahn, B. Bundy, H. Nishikawa et al., Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer, Proceedings of the National Academy of Sciences, vol.102, issue.51, pp.18538-18581, 2005.
DOI : 10.1073/pnas.0509182102

N. Hartmann, N. Giese, T. Giese, I. Poschke, R. Offringa et al., Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer, Clinical Cancer Research, vol.20, issue.13, pp.3422-3455, 2014.
DOI : 10.1158/1078-0432.CCR-13-2972

O. Kawai, G. Ishii, K. Kubota, Y. Murata, Y. Naito et al., T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer, Cancer, vol.116, issue.6, pp.1387-95, 2008.
DOI : 10.1002/cncr.23712

R. Herbst, J. Soria, M. Kowanetz, G. Fine, O. Hamid et al., Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells, Nature J Exp Med, vol.515, issue.20810, pp.563-570, 2011.

C. Feig, J. Jones, M. Kraman, R. Wells, A. Deonarine et al., Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer, Proceedings of the National Academy of Sciences, vol.110, issue.50, pp.20212-20219, 2013.
DOI : 10.1073/pnas.1320318110

G. Motz, S. Santoro, L. Wang, T. Garrabrant, R. Lastra et al., Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors, Nature Medicine, vol.72, issue.6, pp.607-622, 2014.
DOI : 10.4049/jimmunol.181.11.8036

E. Evans, A. Jonason, . Jr, H. Bussler, S. Torno et al., Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies, Cancer Immunology Research, vol.3, issue.6, pp.689-701, 2015.
DOI : 10.1158/2326-6066.CIR-14-0171

H. Salmon, A. Rivas-caicedo, F. Asperti-boursin, C. Lebugle, P. Bourdoncle et al., <em>Ex vivo</em> Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes, Journal of Visualized Experiments, issue.53, pp.3054-3064, 2011.
DOI : 10.3791/3054

F. Asperti-boursin, E. Real, G. Bismuth, A. Trautmann, and E. Donnadieu, CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3???kinase??? independent manner, The Journal of Experimental Medicine, vol.159, issue.5, pp.1167-79, 2007.
DOI : 10.4049/jimmunol.173.1.50

B. Zinselmeyer, S. Heydari, C. Sacristan, D. Nayak, M. Cammer et al., PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis, The Journal of Experimental Medicine, vol.121, issue.4, pp.757-74, 2013.
DOI : 10.1016/S0076-6879(09)05416-0

W. Weninger, M. Biro, and R. Jain, Leukocyte migration in the interstitial space of non-lymphoid??organs, Nature Reviews Immunology, vol.6, issue.4, pp.232-278, 2014.
DOI : 10.1038/nri3641

P. Lu, V. Weaver, and Z. Werb, The extracellular matrix: A dynamic niche in cancer progression, The Journal of Cell Biology, vol.62, issue.4, pp.395-406, 2012.
DOI : 10.1002/1097-0142(19950215)75:4<1010::AID-CNCR2820750417>3.0.CO;2-O

A. Ene-obong, A. Clear, J. Watt, J. Wang, R. Fatah et al., Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma, Gastroenterology, vol.145, issue.5, pp.1121-1153, 2013.
DOI : 10.1053/j.gastro.2013.07.025

K. Tan, M. Evrard, M. Tham, M. Hong, C. Huang et al., Tumor stroma and chemokines control T-cell migration into melanoma following Temozolomide treatment, OncoImmunology, vol.10, issue.11, pp.978709-978719, 2015.
DOI : 10.1158/0008-5472.CAN-03-2828

L. Guidotti, D. Inverso, L. Sironi, D. Lucia, P. Fioravanti et al., Immunosurveillance of the Liver by Intravascular Effector CD8+ T Cells, Cell, vol.161, issue.3, pp.486-500, 2015.
DOI : 10.1016/j.cell.2015.03.005

E. Peranzoni, A. Rivas-caicedo, H. Bougherara, H. Salmon, and E. Donnadieu, Positive and negative influence of the matrix architecture on antitumor immune surveillance, Cellular and Molecular Life Sciences, vol.12, issue.5, pp.4431-4479, 2013.
DOI : 10.1007/s00018-013-1339-8

E. Van-goethem, R. Poincloux, F. Gauffre, I. Maridonneau-parini, L. Cabec et al., Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like Structures, The Journal of Immunology, vol.184, issue.2, pp.1049-61, 2010.
DOI : 10.4049/jimmunol.0902223

URL : https://hal.archives-ouvertes.fr/hal-00869875

P. Mrass, J. Petravic, M. Davenport, and W. Weninger, Cell-autonomous and environmental contributions to the interstitial migration of T cells, Seminars in Immunopathology, vol.204, issue.3, pp.257-74, 2010.
DOI : 10.1007/s00281-010-0212-1

J. Jacobelli, R. Friedman, M. Conti, A. Lennon-dumenil, M. Piel et al., Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA???regulated adhesions, Nature Immunology, vol.334, issue.10, pp.953-61, 1936.
DOI : 10.1016/j.bbrc.2004.06.045