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Long-term immune responses to vaccination in HIV-infected patients: a systematic review and meta-analysis: Responses to vaccines in HIV patients

Abstract : Vaccine-induced antibodies may wane more quickly in persons living with HIV than in healthy individuals. Here, we reviewed the literature on vaccines routinely recommended in HIV-infected patients to estimate how seroprotection decreases over time in those who initially responded to immunization. For each study retrieved from the literature, the decrease of seroprotection was modeled with a log binomial generalized linear model, and data were pooled in a meta-analysis in order to provide estimates of seroprotection two and five years after last vaccine administration. Our analyses confirmed that duration of seroprotection was shorter in HIV-infected patients, and that with current guidelines, a substantial proportion of patients would have lost protective antibodies before being proposed a booster. We therefore discuss the implications on the monitoring of antibody levels and timing of revaccination in these patients.
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Submitted on : Thursday, December 17, 2015 - 1:58:40 PM
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Solen Kernéis, Odile Launay, Clément Turbelin, Frédéric Batteux, Thomas Hanslik, et al.. Long-term immune responses to vaccination in HIV-infected patients: a systematic review and meta-analysis: Responses to vaccines in HIV patients. Clinical Infectious Diseases, Oxford University Press (OUP), 2014, 58 (8), pp.1130-9. ⟨10.1093/cid/cit937⟩. ⟨inserm-01245561⟩

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