 |
Journal articles
Heat shock factor 1 is a potent therapeutic target for enhancing the efficacy of treatments for multiple myeloma with adverse prognosis
Abstract : AbstractDeregulated expression of heat shock proteins (HSPs) encoding genes is frequent in multiple myeloma. HSPs, which are molecular chaperones involved in protein homeostasis pathways, have emerged recently as promising therapeutic targets. Using human myeloma cell lines and primary myeloma cells belonging to various molecular groups, we tested the efficacy of HSP90, HSP70, and heat shock factor 1 (HSF1) inhibitors alone or associated with current antimyeloma drugs. We report here that KNK-437 (an inhibitor of HSF1) and bortezomib have additive effects on apoptosis induction in cells belonging to groups with bad prognosis.
https://www.hal.inserm.fr/inserm-01237704
Contributor : Bmc Bmc <>
Submitted on : Thursday, December 3, 2015 - 4:15:50 PM
Last modification on : Friday, June 19, 2020 - 3:08:41 AM
Long-term archiving on: : Saturday, April 29, 2017 - 5:14:06 AM
Contributor : Bmc Bmc <>
Submitted on : Thursday, December 3, 2015 - 4:15:50 PM
Last modification on : Friday, June 19, 2020 - 3:08:41 AM
Long-term archiving on: : Saturday, April 29, 2017 - 5:14:06 AM
Files
13045_2015_Article_135.pdf
Publication funded by an institution
- 13045_2015_135_MOESM3_ESM.pdf Publication funded by an institution