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Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Abstract : Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.
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https://www.hal.inserm.fr/inserm-01231327
Contributor : Olivier Micheau <>
Submitted on : Thursday, November 19, 2015 - 9:46:21 PM
Last modification on : Friday, January 24, 2020 - 8:02:16 AM

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Mohammed Elmallah, Olivier Micheau. Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). Marine drugs, MDPI, 2015, 13 (11), ⟨10.3390/md13116884⟩. ⟨inserm-01231327⟩

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