Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Abstract : Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.
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Marine drugs, MDPI, 2015, 13 (11), 〈10.3390/md13116884〉
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http://www.hal.inserm.fr/inserm-01231327
Contributeur : Olivier Micheau <>
Soumis le : jeudi 19 novembre 2015 - 21:46:21
Dernière modification le : vendredi 8 juin 2018 - 14:50:12

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Mohammed Elmallah, Olivier Micheau. Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). Marine drugs, MDPI, 2015, 13 (11), 〈10.3390/md13116884〉. 〈inserm-01231327〉

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