O. Reilly, M. Pirie-shepherd, S. Lane, W. Folkman, and J. , Antiangiogenic Activity of the Cleaved Conformation of the Serpin Antithrombin, Science, vol.285, issue.5435, pp.1926-1928, 1999.
DOI : 10.1126/science.285.5435.1926

D. Dawson, O. Volpert, P. Gillis, S. Crawford, H. Xu et al., Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis, Science, vol.285, issue.5425, pp.245-248, 1999.
DOI : 10.1126/science.285.5425.245

L. Devy, S. Blacher, C. Grignet-debrus, K. Bajou, V. Masson et al., The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent, The FASEB Journal, vol.16, issue.2, pp.147-154, 2002.
DOI : 10.1096/fj.01-0552com

S. Becerra and V. Notario, The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential, Nature Reviews Cancer, vol.2012, issue.4, pp.258-271, 2013.
DOI : 10.1038/nrc3484

S. Selbonne, F. Azibani, S. Iatmanen, Y. Boulaftali, B. Richard et al., In Vitro and In Vivo Antiangiogenic Properties of the Serpin Protease Nexin-1, Molecular and Cellular Biology, vol.32, issue.8, pp.1496-1505
DOI : 10.1128/MCB.06554-11

R. Scott, B. Bergman, A. Bajpai, R. Hersh, H. Rodriguez et al., Protease nexin. Properties and a modified purification procedure, J Biol Chem, vol.260, issue.11, pp.7029-7034, 1985.

D. Evans, M. Mcgrogan, R. Scott, and R. Carrell, Protease specificity and heparin binding and activation of recombinant protease nexin I, J Biol Chem, vol.266, issue.33, pp.22307-22312, 1991.

M. Bouton, Y. Boulaftali, B. Richard, V. Arocas, and J. Michel, Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology, Blood, vol.119, issue.11, pp.2452-2457
DOI : 10.1182/blood-2011-10-387464

V. Murer, J. Spetz, U. Hengst, L. Altrogge, A. De-agostini et al., Male fertility defects in mice lacking the serine protease inhibitor protease nexin-1, Proceedings of the National Academy of Sciences, vol.98, issue.6, pp.3029-3033, 2001.
DOI : 10.1073/pnas.051630698

M. Lino, S. Atanasoski, M. Kvajo, B. Fayard, E. Moreno et al., Mice Lacking Protease Nexin-1 Show Delayed Structural and Functional Recovery after Sciatic Nerve Crush, Journal of Neuroscience, vol.27, issue.14, pp.3677-3685, 2007.
DOI : 10.1523/JNEUROSCI.0277-07.2007

URL : http://edoc.unibas.ch/30675/1/20140109131012_52ce91a449746.pdf

Y. Boulaftali, F. Adam, L. Venisse, V. Ollivier, B. Richard et al., Anticoagulant and antithrombotic properties of platelet protease nexin-1, Blood, vol.115, issue.1, pp.97-106, 2010.
DOI : 10.1182/blood-2009-04-217240

M. Fruttiger, Development of the mouse retinal vasculature: angiogenesis versus vasculogenesis, Invest Ophthalmol Vis Sci, vol.43, issue.2, pp.522-527, 2002.

M. Fruttiger, Development of the retinal vasculature, Angiogenesis, vol.10, issue.2, pp.77-88, 2007.
DOI : 10.1007/s10456-007-9065-1

A. Luthi, H. Van-der-putten, F. Botteri, I. Mansuy, M. Meins et al., Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation, J Neurosci, vol.17, issue.12, pp.4688-4699, 1997.

M. Kvajo, H. Albrecht, M. Meins, U. Hengst, E. Troncoso et al., Regulation of Brain Proteolytic Activity Is Necessary for the In Vivo Function of NMDA Receptors, Journal of Neuroscience, vol.24, issue.43, pp.9734-9743, 2004.
DOI : 10.1523/JNEUROSCI.3306-04.2004

H. Gerhardt, M. Golding, M. Fruttiger, C. Ruhrberg, A. Lundkvist et al., VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia, The Journal of Cell Biology, vol.15, issue.6, pp.1163-1177, 2003.
DOI : 10.1002/(SICI)1521-1878(200003)22:3<219::AID-BIES3>3.0.CO;2-A

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172999

S. Claxton and M. Fruttiger, Oxygen modifies artery differentiation and network morphogenesis in the retinal vasculature, Developmental Dynamics, vol.414, issue.3, pp.822-828, 2005.
DOI : 10.1002/dvdy.20407

Y. Boulaftali, D. Francois, L. Venisse, M. Jandrot-perrus, V. Arocas et al., Endothelial Protease Nexin-1 Is a Novel Regulator of A Disintegrin and Metalloproteinase 17 Maturation and Endothelial Protein C Receptor Shedding via Furin Inhibition, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.33, issue.7, pp.1647-1654, 2013.
DOI : 10.1161/ATVBAHA.113.301494

M. Bouton, L. Venisse, B. Richard, C. Pouzet, V. Arocas et al., Protease Nexin-1 Interacts With Thrombomodulin and Modulates Its Anticoagulant Effect, Circulation Research, vol.100, issue.8, pp.1174-1181, 2007.
DOI : 10.1161/01.RES.0000265066.92923.ee

L. Chen, X. Zhang, and K. Chai, Regulation of prostasin expression and function in the prostate, The Prostate, vol.327, issue.1, pp.1-12, 2004.
DOI : 10.1002/pros.10346

B. Richard, V. Arocas, M. Guillin, J. Michel, M. Jandrot-perrus et al., Protease nexin-1: A cellular serpin down-regulated by thrombin in rat aortic smooth muscle cells, Journal of Cellular Physiology, vol.268, issue.1, pp.138-145, 2004.
DOI : 10.1002/jcp.20103

S. Feeney, D. Simpson, T. Gardiner, C. Boyle, P. Jamison et al., Role of Vascular Endothelial Growth Factor and Placental Growth Factors During Retinal Vascular Development and Hyaloid Regression, Investigative Opthalmology & Visual Science, vol.44, issue.2, pp.839-847, 2003.
DOI : 10.1167/iovs.02-0040

J. Baker and R. Gronke, Protease Nexins and Cellular Regulation, Seminars in Thrombosis and Hemostasis, vol.12, issue.03, pp.216-220, 1986.
DOI : 10.1055/s-2007-1003554

M. Bouton, R. B. Rossignol, P. , P. M. Guillin, M. Michel et al., The serpin protease-nexin 1, Jandrot-Perrus M, 2003.

B. Choi, M. Suzuki, T. Kim, S. Wagner, and D. Cunningham, Protease nexin-1. Localization in the human brain suggests a protective role against extravasated serine proteases, Am J Pathol, vol.137, issue.4, pp.741-747, 1990.

I. Gravanis and S. Tsirka, Tissue plasminogen activator and glial function, Glia, vol.14, issue.2, pp.177-183, 2005.
DOI : 10.1002/glia.20115

J. Kim, N. Tran, Z. Li, F. Yang, W. Zhou et al., Brain Endothelial Hemostasis Regulation by Pericytes, Journal of Cerebral Blood Flow & Metabolism, vol.19, issue.2, pp.209-217, 2006.
DOI : 10.1038/227680a0

M. Dorrell, E. Aguilar, C. Weber, and M. Friedlander, Global Gene Expression Analysis of the Developing Postnatal Mouse Retina, Investigative Opthalmology & Visual Science, vol.45, issue.3, pp.1009-1019, 2004.
DOI : 10.1167/iovs.03-0806

M. Dorrell and M. Friedlander, Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina, Progress in Retinal and Eye Research, vol.25, issue.3, pp.277-295, 2006.
DOI : 10.1016/j.preteyeres.2006.01.001

A. Uemura, S. Kusuhara, H. Katsuta, and S. Nishikawa, Angiogenesis in the mouse retina: A model system for experimental manipulation, Experimental Cell Research, vol.312, issue.5, pp.676-683, 2006.
DOI : 10.1016/j.yexcr.2005.10.030

J. Sommer, S. Gloor, G. Rovelli, J. Hofsteenge, H. Nick et al., cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily, Biochemistry, vol.26, issue.20, pp.6407-6410, 1987.
DOI : 10.1021/bi00394a016

N. Simonavicius, M. Ashenden, A. Van-weverwijk, S. Lax, D. Huso et al., Pericytes promote selective vessel regression to regulate vascular patterning, Blood, vol.120, issue.7, pp.1516-1527, 2012.
DOI : 10.1182/blood-2011-01-332338

R. Balsara and V. Ploplis, Plasminogen activator inhibitor-1: The double-edged sword in apoptosis, Thrombosis and Haemostasis, vol.100, issue.6, pp.1029-1036, 2008.
DOI : 10.1160/TH08-07-0427

A. Basu, G. Menicucci, J. Maestas, A. Das, and P. Mcguire, Plasminogen Activator Inhibitor-1 (PAI-1) Facilitates Retinal Angiogenesis in a Model of Oxygen-Induced Retinopathy, Investigative Opthalmology & Visual Science, vol.50, issue.10, pp.4974-4981, 2009.
DOI : 10.1167/iovs.09-3619

Q. Huang, S. Wang, C. Sorenson, and N. Sheibani, PEDF-deficient mice exhibit an enhanced rate of retinal vascular expansion and are more sensitive to hyperoxia-mediated vessel obliteration, Experimental Eye Research, vol.87, issue.3, pp.226-241, 2008.
DOI : 10.1016/j.exer.2008.06.003

T. Ota, K. Ota, H. Jono, H. Fujimori, M. Ueda et al., Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis, Oral Oncology, vol.46, issue.9, pp.657-661, 2010.
DOI : 10.1016/j.oraloncology.2010.06.004

L. Weckbach, L. Groesser, J. Borgolte, J. Pagel, F. Pogoda et al., Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis, AJP: Heart and Circulatory Physiology, vol.303, issue.4, pp.429-438, 2012.
DOI : 10.1152/ajpheart.00934.2011

X. Yang, L. Castilla, X. Xu, C. Li, J. Gotay et al., Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5, Development, vol.126, issue.8, pp.1571-1580, 1999.