K. Ali, M. Middleton, E. Pure, and D. Rader, Apolipoprotein E Suppresses the Type I Inflammatory Response In Vivo, Circulation Research, vol.97, issue.9, pp.922-927, 2005.
DOI : 10.1161/01.RES.0000187467.67684.43

D. Anderson, S. Ozaki, M. Nealon, J. Neitz, R. Mullins et al., Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation, American Journal of Ophthalmology, vol.131, issue.6, pp.767-781, 2001.
DOI : 10.1016/S0002-9394(00)00961-2

E. Ayroldi, O. Zollo, L. Cannarile, D. Adamio, F. Grohmann et al., Interleukin-6 (IL-6) prevents activation-induced cell death, 1998.

K. Azzam and M. Fessler, Crosstalk between reverse cholesterol transport and innate immunity, Trends in Endocrinology & Metabolism, vol.23, issue.4, pp.169-178, 2012.
DOI : 10.1016/j.tem.2012.02.001

S. Basu, Y. Ho, M. Brown, D. Bilheimer, R. Anderson et al., Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes, J Biol Chem, vol.257, pp.9788-9795, 1982.

J. Berbee, L. Havekes, and P. Rensen, Apolipoproteins modulate the inflammatory response to lipopolysaccharide, Journal of Endotoxin Research, vol.11, issue.2, pp.97-103, 2005.
DOI : 10.1179/096805105X35215

S. Camelo, R. W. Lavalette, S. Calippe, B. Cristofaro, B. Levy et al., Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages, Angiogenesis, vol.484, issue.5415, pp.609-622, 2012.
DOI : 10.1007/s10456-012-9290-0

URL : https://hal.archives-ouvertes.fr/inserm-00853034

B. Chang, R. Hurd, J. Wang, and P. Nishina, Survey of Common Eye Diseases in Laboratory Mouse Strains, Investigative Opthalmology & Visual Science, vol.54, issue.7, pp.4974-4981, 2013.
DOI : 10.1167/iovs.13-12289

W. Chen, D. Stambolian, A. Edwards, K. Branham, M. Othman et al., Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration, Proceedings of the National Academy of Sciences, vol.107, issue.16, pp.7401-7406, 2010.
DOI : 10.1073/pnas.0912702107

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867722

M. Chen, C. Luo, R. Penalva, and H. Xu, Paraquat-Induced Retinal Degeneration Is Exaggerated in CX3CR1-Deficient Mice and Is Associated with Increased Retinal Inflammation, Investigative Opthalmology & Visual Science, vol.54, issue.1, pp.682-690, 2013.
DOI : 10.1167/iovs.12-10888

A. Chow, B. Brown, and M. Merad, Studying the mononuclear phagocyte system in the molecular age, Nature Reviews Immunology, vol.83, issue.11, pp.788-798, 2011.
DOI : 10.1038/nri3087

C. Combadiere, C. Feumi, R. W. Keller, N. Rodero, M. Pezard et al., CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration, Journal of Clinical Investigation, vol.117, issue.10, pp.2920-2928, 2007.
DOI : 10.1172/JCI31692DS1

URL : https://hal.archives-ouvertes.fr/inserm-00176389

F. Cruz-guilloty, A. Saeed, J. Echegaray, S. Duffort, A. Ballmick et al., Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration, International Journal of Inflammation, vol.53, issue.6, p.503725, 2013.
DOI : 10.1016/j.bmc.2009.09.009

L. Dong and K. Weisgraber, Human Apolipoprotein E4 Domain Interaction: ARGININE 61 AND GLUTAMIC ACID 255 INTERACT TO DIRECT THE PREFERENCE FOR VERY LOW DENSITY LIPOPROTEINS, Journal of Biological Chemistry, vol.271, issue.32, pp.19053-19057, 1996.
DOI : 10.1074/jbc.271.32.19053

I. Galea, I. Bechmann, and V. Perry, What is immune privilege (not)?, Trends in Immunology, vol.28, issue.1, pp.12-18, 2007.
DOI : 10.1016/j.it.2006.11.004

E. Gautier, S. Ivanov, P. Lesnik, and G. Randolph, Local apoptosis mediates clearance of macrophages from resolving inflammation in mice, Blood, vol.122, issue.15, pp.2714-2722, 2013.
DOI : 10.1182/blood-2013-01-478206

P. Greaney, A. Nahimana, L. Lagopoulos, A. Etter, D. Aubry et al., A Fas agonist induces high levels of apoptosis in haematological malignancies, Leukemia Research, vol.30, issue.4, pp.415-426, 2006.
DOI : 10.1016/j.leukres.2005.08.006

T. Griffith, T. Brunner, S. Fletcher, D. Green, and T. Ferguson, Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege, Science, vol.270, issue.5239, pp.1189-1192, 1995.
DOI : 10.1126/science.270.5239.1189

L. Guo, M. Ladu, V. Eldik, and L. , A Dual Role for Apolipoprotein E in Neuroinflammation: Anti- and Pro-Inflammatory Activity, Journal of Molecular Neuroscience, vol.23, issue.3, pp.205-212, 2004.
DOI : 10.1385/JMN:23:3:205

N. Gupta, K. Brown, and A. Milam, Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration, Experimental Eye Research, vol.76, issue.4, pp.463-471, 2003.
DOI : 10.1016/S0014-4835(02)00332-9

G. Hageman, P. Luthert, V. Chong, N. Johnson, L. Anderson et al., An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration, Progress in Retinal and Eye Research, vol.20, issue.6, pp.705-732, 2001.
DOI : 10.1016/S1350-9462(01)00010-6

J. Heeren, T. Grewal, A. Laatsch, N. Becker, F. Rinninger et al., Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation, Journal of Biological Chemistry, vol.279, issue.53, pp.55483-55492, 2004.
DOI : 10.1074/jbc.M409324200

M. Houssier, R. W. Lavalette, S. Keller, N. Guillonneau, X. Baragatti et al., CD36 Deficiency Leads to Choroidal Involution via COX2 Down-Regulation in Rodents, PLoS Medicine, vol.278, issue.2, pp.39-263, 2004.
DOI : 10.1371/journal.pmed.0050039.g004

URL : https://hal.archives-ouvertes.fr/inserm-00258554

L. Johnson, D. Forest, C. Banna, C. Radeke, M. Maloney et al., Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration, Proceedings of the National Academy of Sciences, vol.108, issue.45, pp.18277-18282, 2011.
DOI : 10.1073/pnas.1109703108

S. Kang, D. Schneider, Z. Lin, D. Hanahan, D. Dichek et al., Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction, Nature Medicine, vol.26, issue.7, pp.738-743, 1997.
DOI : 10.1074/jbc.271.47.29969

J. Kezic, X. Chen, E. Rakoczy, and P. Mcmenamin, Diabetic Mouse, Investigative Opthalmology & Visual Science, vol.54, issue.1, pp.854-863, 2013.
DOI : 10.1167/iovs.12-10876

P. Kiener, P. Davis, G. Starling, C. Mehlin, S. Klebanoff et al., Differential Induction of Apoptosis by Fas???Fas Ligand Interactions in Human Monocytes and Macrophages, The Journal of Experimental Medicine, vol.86, issue.8, pp.1511-1516, 1997.
DOI : 10.1002/eji.1830241111

C. Klaver, M. Kliffen, C. Van-duijn, A. Hofman, M. Cruts et al., Genetic Association of Apolipoprotein E with Age-Related Macular Degeneration, The American Journal of Human Genetics, vol.63, issue.1, pp.200-206, 1998.
DOI : 10.1086/301901

R. Klein, T. Peto, A. Bird, and M. Vannewkirk, The epidemiology of age-related macular degeneration, American Journal of Ophthalmology, vol.137, issue.3, pp.486-495, 2004.
DOI : 10.1016/j.ajo.2003.11.069

R. Klein, M. Knudtson, B. Klein, T. Wong, M. Cotch et al., Inflammation, Complement Factor H, and Age-Related Macular Degeneration, Ophthalmology, vol.115, issue.10, pp.1742-1749, 2008.
DOI : 10.1016/j.ophtha.2008.03.021

URL : http://doi.org/10.1016/j.ophtha.2008.03.021

R. Klein, C. Myers, K. Cruickshanks, R. Gangnon, L. Danforth et al., Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction and the 20-Year Cumulative Incidence of Early Age-Related Macular Degeneration, JAMA Ophthalmology, vol.132, issue.4, pp.446-455, 2014.
DOI : 10.1001/jamaophthalmol.2013.7671

H. Kohno, Y. Chen, B. Kevany, E. Pearlman, M. Miyagi et al., Photoreceptor Proteins Initiate Microglial Activation via Toll-like Receptor 4 in Retinal Degeneration Mediated by All-trans-retinal, Journal of Biological Chemistry, vol.288, issue.21, 2013.
DOI : 10.1074/jbc.M112.448712

M. Koss, J. Hoffmann, N. Nguyen, M. Pfister, H. Mischak et al., Proteomics of Vitreous Humor of Patients with Exudative Age-Related Macular Degeneration, PLoS ONE, vol.2012, issue.5, p.96895, 2014.
DOI : 10.1371/journal.pone.0096895.t004

M. Linton, J. Atkinson, and S. Fazio, Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation, Science, vol.267, issue.5200, pp.1034-1037, 1995.
DOI : 10.1126/science.7863332

U. Luhmann, C. Lange, R. S. Munro, P. Cowing, J. Armer et al., Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling, PLoS ONE, vol.152, issue.4, p.35551, 2012.
DOI : 10.1371/journal.pone.0035551.s002

W. Ma, L. Zhao, A. Fontainhas, R. Fariss, and W. Wong, Microglia in the Mouse Retina Alter the Structure and Function of Retinal Pigmented Epithelial Cells: A Potential Cellular Interaction Relevant to AMD, PLoS ONE, vol.4, issue.11, p.7945, 2009.
DOI : 10.1371/journal.pone.0007945.t001

R. Mahley, S. Rall, and . Jr, E: Far More Than a Lipid Transport Protein, Annual Review of Genomics and Human Genetics, vol.1, issue.1, pp.507-537, 2000.
DOI : 10.1146/annurev.genom.1.1.507

G. Malek, L. Johnson, B. Mace, P. Saloupis, D. Schmechel et al., Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration, Proceedings of the National Academy of Sciences, vol.102, issue.33, pp.11900-11905, 2005.
DOI : 10.1073/pnas.0503015102

F. Matsuura, N. Wang, W. Chen, X. Jiang, and A. Tall, HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway, Journal of Clinical Investigation, vol.116, issue.5, 2006.
DOI : 10.1172/JCI27602DS1

G. Mckay, C. Patterson, U. Chakravarthy, S. Dasari, C. Klaver et al., with age-related macular degeneration - a pooled analysis of 15 studies, Human Mutation, vol.45, issue.12, pp.1407-1416, 2011.
DOI : 10.1002/humu.21577

R. Molday, D. Hicks, and L. Molday, Peripherin. A rim-specific membrane protein of rod outer segment discs, Invest Ophthalmol Vis Sci, vol.28, pp.50-61, 1987.

S. Mooijaart, J. Berbee, D. Van-heemst, L. Havekes, A. De-craen et al., ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age, PLoS Medicine, vol.16, issue.6, p.176, 2006.
DOI : 10.1371/journal.pmed.0030176.t006

M. Nakai, T. Kawamata, T. Taniguchi, K. Maeda, and C. Tanaka, Expression of apolipoprotein E mRNA in rat microglia, Neuroscience Letters, vol.211, issue.1, pp.41-44, 1996.
DOI : 10.1016/0304-3940(96)12716-6

H. Oh, H. Takagi, C. Takagi, K. Suzuma, A. Otani et al., The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes, Invest Ophthalmol Vis Sci, vol.40, pp.1891-1898, 1999.

J. Ong, N. Zorapapel, K. Rich, R. Wagstaff, R. Lambert et al., Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice, Invest Ophthalmol Vis Sci, vol.42, pp.1891-1900, 2001.

D. Park, A. Thomsen, C. Frevert, U. Pham, S. Skerrett et al., Fas (CD95) Induces Proinflammatory Cytokine Responses by Human Monocytes and Monocyte-Derived Macrophages, The Journal of Immunology, vol.170, issue.12, pp.6209-6216, 2003.
DOI : 10.4049/jimmunol.170.12.6209

P. Penfold, M. Killingsworth, and S. Sarks, Senile macular degeneration: The involvement of immunocompetent cells, Graefe's Archive for Clinical and Experimental Ophthalmology, vol.121, issue.2, pp.69-76, 1985.
DOI : 10.1007/BF02150948

F. Peri and C. Nusslein-volhard, Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo, Cell, vol.133, issue.5, pp.916-927, 2008.
DOI : 10.1016/j.cell.2008.04.037

R. Ransohoff, Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology, Immunity, vol.31, issue.5, pp.711-721, 2009.
DOI : 10.1016/j.immuni.2009.09.010

W. Raoul, N. Keller, M. Rodero, F. Behar-cohen, F. Sennlaub et al., Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells, Journal of Neuroimmunology, vol.198, issue.1-2, pp.56-61, 2008.
DOI : 10.1016/j.jneuroim.2008.04.014

URL : https://hal.archives-ouvertes.fr/inserm-00311574

D. Riddell, H. Zhou, K. Atchison, H. Warwick, P. Atkinson et al., Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels, Journal of Neuroscience, vol.28, issue.45, pp.11445-11453, 2008.
DOI : 10.1523/JNEUROSCI.1972-08.2008

M. Rosenfeld, S. Butler, V. Ord, B. Lipton, C. Dyer et al., Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.13, issue.9, pp.1382-1389, 1993.
DOI : 10.1161/01.ATV.13.9.1382

M. Rutar, R. Natoli, and J. Provis, Small interfering RNA-mediated suppression of Ccl2 in M??ller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration, Journal of Neuroinflammation, vol.452, issue.5, p.221, 2012.
DOI : 10.1186/1742-2094-9-221

E. Sakurai, A. Anand, B. Ambati, N. Van-rooijen, and J. Ambati, Macrophage Depletion Inhibits Experimental Choroidal Neovascularization, Investigative Opthalmology & Visual Science, vol.44, issue.8, pp.3578-3585, 2003.
DOI : 10.1167/iovs.03-0097

S. Sarks, Ageing and degeneration in the macular region: a clinico-pathological study., British Journal of Ophthalmology, vol.60, issue.5, pp.324-341, 1976.
DOI : 10.1136/bjo.60.5.324

S. Sather, K. Kenyon, J. Lefkowitz, X. Liang, B. Varnum et al., A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation, Blood, vol.109, issue.3, pp.1026-1033, 2007.
DOI : 10.1182/blood-2006-05-021634

G. Schmitz and E. Orso, CD14 signalling in lipid rafts: new ligands and co-receptors, Current Opinion in Lipidology, vol.13, issue.5, pp.513-521, 2002.
DOI : 10.1097/00041433-200210000-00007

J. Seddon, S. George, B. Rosner, and N. Rifai, Progression of Age-Related Macular Degeneration, Archives of Ophthalmology, vol.123, issue.6, pp.774-782, 2005.
DOI : 10.1001/archopht.123.6.774

F. Sennlaub, C. Auvynet, B. Calippe, S. Lavalette, L. Poupel et al., deficient mice, EMBO Molecular Medicine, vol.48, issue.11, pp.1775-1793, 2013.
DOI : 10.1002/emmm.201302692

URL : https://hal.archives-ouvertes.fr/inserm-00315944

M. Silverman, D. Zamora, Y. Pan, P. Texeira, S. Baek et al., Constitutive and Inflammatory Mediator-Regulated Fractalkine Expression in Human Ocular Tissues and Cultured Cells, Investigative Opthalmology & Visual Science, vol.44, issue.4, pp.1608-1615, 2003.
DOI : 10.1167/iovs.02-0233

K. Smoak, J. Aloor, J. Madenspacher, B. Merrick, J. Collins et al., Myeloid Differentiation Primary Response Protein 88 Couples Reverse Cholesterol Transport to Inflammation, Cell Metabolism, vol.11, issue.6, pp.493-502, 2010.
DOI : 10.1016/j.cmet.2010.04.006

J. Streilein, N. Ma, H. Wenkel, T. Ng, and P. Zamiri, Immunobiology and privilege of neuronal retina and pigment epithelium transplants, Vision Research, vol.42, issue.4, pp.487-495, 2002.
DOI : 10.1016/S0042-6989(01)00185-7

M. Suzuki, M. Tsujikawa, H. Itabe, Z. Du, P. Xie et al., Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration, Journal of Cell Science, vol.125, issue.10, pp.2407-2415, 2012.
DOI : 10.1242/jcs.097683

C. Tsutsumi, K. Sonoda, K. Egashira, H. Qiao, T. Hisatomi et al., The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization, Journal of Leukocyte Biology, vol.74, issue.1, pp.25-32, 2003.
DOI : 10.1189/jlb.0902436

H. Um, J. Orenstein, and S. Wahl, Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway, 1996.

H. Wenkel and J. Streilein, Evidence that retinal pigment epithelium functions as an immune-privileged tissue, Invest Ophthalmol Vis Sci, vol.41, pp.3467-3473, 2000.

L. Zhao, S. Lin, K. Bales, V. Gelfanova, D. Koger et al., Macrophage-Mediated Degradation of ??-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism, Journal of Neuroscience, vol.29, issue.11, pp.3603-3612, 2009.
DOI : 10.1523/JNEUROSCI.5302-08.2009

M. Zieger, P. Ahnelt, and P. Uhrin, CX3CL1 (Fractalkine) Protein Expression in Normal and Degenerating Mouse Retina: In Vivo Studies, PLoS ONE, vol.32, issue.9, p.106562, 2014.
DOI : 10.1371/journal.pone.0106562.s003