Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, Science, vol.261, issue.5123, pp.921-923, 1993. ,
DOI : 10.1126/science.8346443
Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases, The Lancet, vol.342, issue.8873, pp.710-711, 1993. ,
DOI : 10.1016/0140-6736(93)91709-U
Association of apolipoprotein E allele ??4 with late-onset familial and sporadic Alzheimer's disease, Neurology, vol.43, issue.8, pp.1467-1472, 1993. ,
DOI : 10.1212/WNL.43.8.1467
Education halves the risk of dementia due to apolipoprotein e4 allele: a collaborative study from the Swedish brain power initiative, Neurobiol Aging, vol.33, pp.1007-1008, 2012. ,
How can elderly apolipoprotein E ??4 carriers remain free from dementia?, Neurobiology of Aging, vol.34, issue.1, pp.13-21, 2013. ,
DOI : 10.1016/j.neurobiolaging.2012.03.003
Apolipoprotein E gene, environmental risk factors, and their interactions in dementia among seniors, International Journal of Geriatric Psychiatry, vol.36, issue.10, pp.1005-1014, 2013. ,
DOI : 10.1111/j.1758-5872.2012.00222.x
Imaging Brain Effects of APOE4 in Cognitively Normal Individuals Across the Lifespan, Neuropsychology Review, vol.67, issue.7, pp.290-299, 2014. ,
DOI : 10.1007/s11065-014-9263-8
Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders, NeuroImage, vol.83, pp.450-457, 2013. ,
DOI : 10.1016/j.neuroimage.2013.06.053
URL : https://hal.archives-ouvertes.fr/inserm-00844867
Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease, Neurology, vol.80, issue.13, pp.1194-1201, 2013. ,
DOI : 10.1212/WNL.0b013e31828970c2
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI, J Lipid Res, vol.31, pp.545-548, 1990. ,
Region-Specific Hierarchy between Atrophy, Hypometabolism, and ??-Amyloid (A??) Load in Alzheimer's Disease Dementia, Journal of Neuroscience, vol.32, issue.46, pp.16265-16273, 2012. ,
DOI : 10.1523/JNEUROSCI.2170-12.2012
Metabolic Networks Underlying Cognitive Reserve in Prodromal Alzheimer Disease: A European Alzheimer Disease Consortium Project, Journal of Nuclear Medicine, vol.54, issue.6, pp.894-902, 2013. ,
DOI : 10.2967/jnumed.112.113928
Clinical evaluation of memory [in French], Rev Neurol, vol.154, issue.2, pp.18-32, 1998. ,
Examination and memory [in French], Rev Prat, vol.41, pp.866-868, 1991. ,
Cognitive Reserve???Mediated Modulation of Positron Emission Tomographic Activations During Memory Tasks in Alzheimer Disease, Archives of Neurology, vol.61, issue.1, pp.73-78, 2004. ,
DOI : 10.1001/archneur.61.1.73
Physical activity and amyloid-?? plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing, Molecular Psychiatry, vol.8, issue.8, pp.875-881, 2013. ,
DOI : 10.1177/153331750301800405
Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition, Arch Neurol, vol.69, pp.636-643, 2012. ,
Apolipoprotein E ??4 magnifies lifestyle risks for dementia: a population-based study, Journal of Cellular and Molecular Medicine, vol.25, issue.6b, pp.2762-2771, 2008. ,
DOI : 10.1111/j.1582-4934.2008.00296.x
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease, The Lancet Neurology, vol.4, issue.11, pp.705-711, 2005. ,
DOI : 10.1016/S1474-4422(05)70198-8
Cognitive reserve proxies relate to gray matter loss in cognitively healthy elderly with abnormal cerebrospinal fluid amyloid-b levels, J Alzheimers Dis, vol.35, pp.715-726, 2013. ,
Effect of Cognitive Reserve Markers on Alzheimer Pathologic Progression, Alzheimer Disease & Associated Disorders, vol.27, issue.4, pp.343-350, 2013. ,
DOI : 10.1097/WAD.0b013e3182900b2b
The Relevance of Beta-Amyloid on Markers of Alzheimer???s Disease in Clinically Normal Individuals and Factors That Influence These Associations, Neuropsychology Review, vol.27, issue.Suppl 3, pp.300-312, 2014. ,
DOI : 10.1007/s11065-014-9267-4
Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve, Trends in Cognitive Sciences, vol.17, issue.10, pp.502-509, 2013. ,
DOI : 10.1016/j.tics.2013.08.012
Association of lifetime cognitive engagement and low b-amyloid deposition, Arch Neurol, vol.69, pp.623-629, 2012. ,
Exercise and Alzheimer's disease biomarkers in cognitively normal older adults, Annals of Neurology, vol.88, issue.3, pp.311-318, 2010. ,
DOI : 10.1002/ana.22096
What is cognitive reserve? Theory and research application of the reserve concept, Journal of the International Neuropsychological Society, vol.8, issue.03, pp.448-460, 2002. ,
DOI : 10.1017/S1355617702813248
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia, Proceedings of the National Academy of Sciences, vol.101, issue.1, pp.284-289, 2004. ,
DOI : 10.1073/pnas.2635903100
Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ??4 Allele for Apolipoprotein E, New England Journal of Medicine, vol.334, issue.12, pp.752-758, 1996. ,
DOI : 10.1056/NEJM199603213341202
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease, Proceedings of the National Academy of Sciences, vol.97, issue.11, pp.6037-6042, 2000. ,
DOI : 10.1073/pnas.090106797
Apolipoprotein E Type 4 Allele and Cerebral Glucose Metabolism in Relatives at Risk for Familial Alzheimer Disease, JAMA: The Journal of the American Medical Association, vol.273, issue.12, pp.942-947, 1995. ,
DOI : 10.1001/jama.1995.03520360056039
Characterizing the normative profile of 18F-FDG PET brain imaging: Sex difference, aging effect, and cognitive reserve, Psychiatry Research: Neuroimaging, vol.221, issue.1, pp.78-85, 2014. ,
DOI : 10.1016/j.pscychresns.2013.10.009
Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve ,
Fibrillar amyloid-?? burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease, Proceedings of the National Academy of Sciences, vol.106, issue.16, pp.6820-6825, 2009. ,
DOI : 10.1073/pnas.0900345106
Apolipoprotein E as a ??-amyloid-independent factor in Alzheimer???s disease, Alzheimer's Research & Therapy, vol.5, issue.5 ,
DOI : 10.1016/S0197-4580(02)00016-7
Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study, The Lancet Neurology, vol.6, issue.6, pp.494-500, 2007. ,
DOI : 10.1016/S1474-4422(07)70106-0
Hippocampal volume differences between healthy young apolipoprotein E e2 and e4 carriers, J Alzheimers Dis, vol.26, pp.207-210, 2011. ,
Apolipoprotein E, Not Fibrillar ??-Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging, Journal of Neuroscience, vol.32, issue.50, pp.18227-18233, 2012. ,
DOI : 10.1523/JNEUROSCI.3266-12.2012