Metabolism of inflammation limited by AMPK and pseudo-starvation, Nature, vol.50, issue.7432, pp.346-55, 2013. ,
DOI : 10.1038/nature11862
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1804, issue.3, pp.581-91, 2010. ,
DOI : 10.1016/j.bbapap.2009.09.012
Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation, Expert Opinion on Investigational Drugs, vol.12, issue.8, pp.1155-67, 2012. ,
DOI : 10.1677/JOE-09-0056
Role of nuclear factor ??b in synovial inflammation, Current Rheumatology Reports, vol.31, issue.3, pp.201-208, 2002. ,
DOI : 10.1007/s11926-002-0066-1
Signal transduction networks in rheumatoid arthritis, Annals of the Rheumatic Diseases, vol.62, issue.90002, pp.86-95, 2003. ,
DOI : 10.1136/ard.62.suppl_2.ii86
Evolving concepts of rheumatoid arthritis, Nature, vol.241, issue.6937, pp.356-61, 2003. ,
DOI : 10.1093/rheumatology/39.10.1060
Signalling, inflammation and arthritis: NF-??B and its relevance to arthritis and inflammation, Rheumatology, vol.47, issue.5, pp.584-90, 2008. ,
DOI : 10.1093/rheumatology/kem298
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial???monocyte interaction, Journal of Neuroscience Research, vol.281, issue.3, pp.614-639, 2006. ,
DOI : 10.1002/jnr.20953
Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury, AJP: Lung Cellular and Molecular Physiology, vol.295, issue.3, pp.497-504, 2008. ,
DOI : 10.1152/ajplung.90210.2008
Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide Ribonucleoside with Protective Effect in Dextran Sulfate Sodium-Induced Acute and Chronic Colitis, Journal of Pharmacology and Experimental Therapeutics, vol.333, issue.3, pp.717-742, 2010. ,
DOI : 10.1124/jpet.109.164954
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome, Cell Metabolism, vol.3, issue.6, pp.403-419, 2006. ,
DOI : 10.1016/j.cmet.2006.05.005
Caspase 1??????independent activation of interleukin-1???? in neutrophil-predominant inflammation, Arthritis & Rheumatism, vol.9, issue.12, pp.3642-50, 2009. ,
DOI : 10.1002/art.24959
K/BxN Serum Transfer Arthritis as a Model of Inflammatory Joint Pain, Methods Mol Biol, vol.851, pp.249-60, 2012. ,
DOI : 10.1007/978-1-61779-561-9_19
Liposomal clodronate eliminates synovial macrophages, reduces inflammation and ameliorates joint destruction in antigen-induced arthritis, Rheumatology, vol.38, issue.9, pp.818-843, 1999. ,
DOI : 10.1093/rheumatology/38.9.818
Targeting IL-6 in the treatment of inflammatory and autoimmune diseases, Expert Opinion on Investigational Drugs, vol.58, issue.10, pp.1457-66, 2009. ,
DOI : 10.1038/nbt0908-957
Actual status of antiinterleukin-1 therapies in rheumatic diseases, Current Opinion in Rheumatology, vol.22, issue.3, pp.246-51, 2010. ,
DOI : 10.1097/BOR.0b013e3283373fa0
Targeting TNF for Treatment of Cancer and Autoimmunity, Adv Exp Med Biol, vol.647, pp.37-51, 2009. ,
DOI : 10.1007/978-0-387-89520-8_3
Hematopoietic AMPK ??1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity, Journal of Clinical Investigation, vol.121, issue.12, pp.4903-4918, 2011. ,
DOI : 10.1172/JCI58577DS1
Berberine suppresses proinflammatory responses through AMPK activation in macrophages, AJP: Endocrinology and Metabolism, vol.296, issue.4, pp.955-64, 2008. ,
DOI : 10.1152/ajpendo.90599.2008
Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype, The Journal of Immunology, vol.181, issue.12, pp.8633-8674, 2008. ,
DOI : 10.4049/jimmunol.181.12.8633
Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models, Diabetologia, vol.347, issue.5, pp.1482-94, 2012. ,
DOI : 10.1007/s00125-012-2494-4
Metformin inhibits TNF-??-induced I??B kinase phosphorylation, I??B-?? degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation, International Journal of Cardiology, vol.134, issue.2, pp.169-75, 2009. ,
DOI : 10.1016/j.ijcard.2008.04.010
Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis, International Immunopharmacology, vol.16, issue.1, pp.85-92, 2013. ,
DOI : 10.1016/j.intimp.2013.03.020
AMPK inhibition in health and disease, Critical Reviews in Biochemistry and Molecular Biology, vol.279, issue.2, pp.276-95, 2010. ,
DOI : 10.1152/ajplung.90210.2008
URL : https://hal.archives-ouvertes.fr/inserm-00489848
5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-?? production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages, Biochemical and Biophysical Research Communications, vol.318, issue.2, pp.372-80, 2004. ,
DOI : 10.1016/j.bbrc.2004.04.035
Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications, Pharmaceutical Research, vol.61, issue.7, pp.1227-51, 2007. ,
DOI : 10.1007/s11095-007-9254-z
Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase, Journal of Biological Chemistry, vol.282, issue.45, pp.32549-60, 2007. ,
DOI : 10.1074/jbc.M706536200
Differential effects of AMPK agonists on cell growth and metabolism, Oncogene, vol.281, issue.28, 2014. ,
DOI : 10.1073/pnas.1312570111
A-769662 activates AMPK ??1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle, AJP: Cell Physiology, vol.297, issue.4, pp.1041-52, 2009. ,
DOI : 10.1152/ajpcell.00051.2009
AMP-activated protein kinase activator A-769662 is an inhibitor of the Na+-K+-ATPase, AJP: Cell Physiology, vol.297, issue.6, pp.1554-66, 2009. ,
DOI : 10.1152/ajpcell.00010.2009
AMP-activated protein kinase inhibits NF-??B signaling and inflammation: impact on healthspan and lifespan, Journal of Molecular Medicine, vol.9, issue.7, pp.667-76, 2011. ,
DOI : 10.1007/s00109-011-0748-0
Macrophage ??1 AMP-activated Protein Kinase (??1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1, Journal of Biological Chemistry, vol.285, issue.25, pp.19051-19060, 2010. ,
DOI : 10.1074/jbc.M110.123620
Targeting Interleukin-6 in Rheumatoid Arthritis, Drugs, vol.71, issue.10, pp.341-56, 2013. ,
DOI : 10.1007/s40265-013-0018-2
Metabolic Syndrome in Rheumatoid Arthritis, Mediators of Inflammation, vol.14, issue.4, pp.710928-710938, 2013. ,
DOI : 10.1038/nrrheum.2012.158
MAPKs and their relevance to arthritis and inflammation, Rheumatology, vol.47, issue.4, pp.409-423, 2008. ,
DOI : 10.1093/rheumatology/kem297
Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor ??B signalling in rat skeletal muscle cells by AMP-activated protein kinase, Biochemical Journal, vol.290, issue.2, pp.463-74, 2011. ,
DOI : 10.1152/ajpendo.00293.2009
5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF??-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling, Molecular Cancer Therapeutics, vol.6, issue.5, pp.1562-71, 2007. ,
DOI : 10.1158/1535-7163.MCT-06-0800