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UCP2 induces metabolic reprogramming to inhibit proliferation of cancer cells

Abstract : Invalidation of uncoupling protein 2 (Ucp2) increases glucose utilization and proliferation in normal cells. We recently reported that cancer cells that overexpress UCP2 become less tumorigenic while switching their metabolism from glycolysis to oxidative phosphorylation. UCP2 appears to be a key regulator of cellular metabolism with a relevant function against tumorigenesis.
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https://www.hal.inserm.fr/inserm-01207304
Contributor : Mireille Bos <>
Submitted on : Wednesday, September 30, 2015 - 2:49:58 PM
Last modification on : Friday, June 19, 2020 - 3:08:41 AM
Long-term archiving on: : Thursday, December 31, 2015 - 10:34:11 AM

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Esteves Pauline, Claire Pecqueur, Alves-Guerra Marie-Clotilde. UCP2 induces metabolic reprogramming to inhibit proliferation of cancer cells. Molecular & Cellular Oncology, Taylor et Francis, 2014, 2 (1), ⟨10.4161/23723556.2014.975024⟩. ⟨inserm-01207304⟩

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