Ebola virus dynamics in mice treated with favipiravir

Abstract : The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease. Here, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with Ebola virus, which were either left untreated or treated with favipiravir at 6 or 8 days post infection. This approach provided estimates of kinetic parameters of Ebola virus reproduction, such as the half-life of productively infected cells, of about 6 hours, and the basic reproductive number which indicates that virus produced by a single infected cell productively infects about 9 new cells. Furthermore, the model predicted that favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6 days after initiation of treatment, respectively. The model could be particularly helpful to guide future studies evaluating favipiravir in larger animals.
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Submitted on : Wednesday, September 9, 2015 - 10:15:04 AM
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Vincent Madelain, Lisa Oestereich, Frederik Graw, Thi-Huyen Nguyen, Xavier de Lamballerie, et al.. Ebola virus dynamics in mice treated with favipiravir. Antiviral Research, Elsevier Masson, 2015, pp.10.1016/j.antiviral.2015.08.015. ⟨10.1016/j.antiviral.2015.08.015⟩. ⟨inserm-01196078⟩



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