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Characterization of normal and cancer stem cells: One experimental paradigm for two kinds of stem cells

Abstract : The characterization of normal stem cells and cancer stem cells uses the same paradigm. These cells are isolated by a Fluorescent-Activated Cell Sorting step and their stemness is assayed following implantation into animals. However, differences exist between these two kinds of stem cells. Therefore, the translation of the experimental procedures used for normal stem cell isolation into the cancer stem cell research field is a potential source of artefacts. In addition, normal stem cell therapy has for objective the regeneration of a tissue, while cancer stem cell-centred therapy seeks the destruction of the cancer tissue. Taking these differences into account is critical for anticipating problems that might arise in cancer stem cell-centred therapy and for upgrading the cancer stem cell paradigm accordingly.
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https://www.hal.inserm.fr/inserm-01194520
Contributor : Didier Wion <>
Submitted on : Monday, September 7, 2015 - 10:45:57 AM
Last modification on : Friday, November 6, 2020 - 3:53:37 AM
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Bioessays 2009 31 993-1001.pdf
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Jean-François Mayol, Corinne Loeuillet, Francis Hérodin, Didier Wion. Characterization of normal and cancer stem cells: One experimental paradigm for two kinds of stem cells. BioEssays, Wiley-VCH Verlag, 2009, pp.993-1001. ⟨10.1002/bies.200900041⟩. ⟨inserm-01194520⟩

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