Lipoic acid -the drug of the future?, Pharmacol Rep, vol.57, pp.570-577, 2005. ,
??-Lipoic Acid: A Metabolic Antioxidant and Potential Redox Modulator of Transcription, Adv Pharmacol, vol.38, pp.79-101, 1997. ,
DOI : 10.1016/S1054-3589(08)60980-1
Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1790, issue.10, pp.1149-60, 1790. ,
DOI : 10.1016/j.bbagen.2009.07.026
Molecular aspects of lipoic acid in the prevention of diabetes complications, Nutrition, vol.17, issue.10, pp.888-95, 2001. ,
DOI : 10.1016/S0899-9007(01)00658-X
The effects of lipoic acid and ??-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial, Diabetes Research and Clinical Practice, vol.92, issue.2, pp.253-60, 2011. ,
DOI : 10.1016/j.diabres.2011.02.010
Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo, Cancer Biology & Therapy, vol.284, issue.14, pp.1425-1460, 2012. ,
DOI : 10.1002/jcp.20494
alpha-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-kappaB induction of RPS6KA4, Anticancer Drugs, vol.24, pp.555-65, 2013. ,
Effects of ??-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells, Nutrition Research and Practice, vol.3, issue.4, pp.265-71, 2009. ,
DOI : 10.4162/nrp.2009.3.4.265
??-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells, Cancer Letters, vol.335, issue.2, pp.472-480, 2013. ,
DOI : 10.1016/j.canlet.2013.03.008
The natural antioxidant alpha-lipoic acid induces p27Kip1-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells, European Journal of Pharmacology, vol.641, issue.1, pp.29-34, 2010. ,
DOI : 10.1016/j.ejphar.2010.05.009
Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin, Investigational New Drugs, vol.37, issue.2, pp.256-64, 2013. ,
DOI : 10.1007/s10637-012-9849-z
URL : https://hal.archives-ouvertes.fr/hal-00761761
Alpha-lipoic acid modulates ovarian surface epithelial cell growth, Gynecologic Oncology, vol.103, issue.1, pp.45-52, 2006. ,
DOI : 10.1016/j.ygyno.2006.01.060
Safety evaluation of ??-lipoic acid (ALA), Regulatory Toxicology and Pharmacology, vol.46, issue.1, pp.29-41, 2006. ,
DOI : 10.1016/j.yrtph.2006.06.004
Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants, Folia Neuropathol, vol.39, pp.147-54, 2001. ,
Increased ROS generation and p53 activation in ??-lipoic acid-induced apoptosis of hepatoma cells, Apoptosis, vol.3, issue.1, pp.113-136, 2007. ,
DOI : 10.1007/s10495-006-0487-9
The secrets of the Bcl-2 family, Cell Death and Differentiation, vol.1813, issue.11, pp.1733-1773, 2012. ,
DOI : 10.1083/jcb.201002018
The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant, Nat Cell Biol, vol.2, pp.156-62, 2000. ,
A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia, Cancer Gene Therapy, vol.82, issue.1, pp.1-7, 2013. ,
DOI : 10.1182/blood-2009-02-207654
Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2, Biochemical Journal, vol.3, issue.3, pp.545-51, 2011. ,
DOI : 10.1038/sj.cdd.4400868
Bcl-XL and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis, Int J Cancer, vol.126, pp.885-95, 2010. ,
Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatment, Gynecologic Oncology, vol.101, issue.3, pp.507-526, 2006. ,
DOI : 10.1016/j.ygyno.2005.11.017
Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells, Journal of Ovarian Research, vol.6, issue.1, p.72, 2013. ,
DOI : 10.1016/j.cell.2011.06.050
Downregulation of Bcl-xL and Mcl-1 is sufficient to induce cell death in mesothelioma cells highly refractory to conventional chemotherapy, Carcinogenesis, vol.31, issue.6, pp.984-93, 2010. ,
DOI : 10.1093/carcin/bgq026
Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1, Biochemical and Biophysical Research Communications, vol.434, issue.4, pp.809-823, 2013. ,
DOI : 10.1016/j.bbrc.2013.04.018
Platinum compounds sensitize ovarian carcinoma cells to ABT-737 by modulation of the Mcl-1/Noxa axis, Apoptosis, vol.77, issue.4, pp.492-508, 2013. ,
DOI : 10.1007/s10495-012-0799-x
URL : https://hal.archives-ouvertes.fr/inserm-00872602
Effect of citrate on malignant pleural mesothelioma cells: a synergistic effect with cisplatin, Anticancer Res, vol.29, pp.1249-54, 2009. ,
Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice, Blood, vol.122, issue.14, pp.2402-2413, 2013. ,
DOI : 10.1182/blood-2013-01-478651
A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1826, issue.2, pp.423-456, 1826. ,
DOI : 10.1016/j.bbcan.2012.07.001
Citrate kills tumor cells through activation of apical caspases, Cellular and Molecular Life Sciences, vol.46, issue.14, pp.4229-4266, 2012. ,
DOI : 10.1007/s00018-012-1166-3
siPGK1 Sensitizes Chemoresistant Human Ovarian Cancer Cell Lines to Cisplatin, Anticancer Res, vol.32, pp.4277-86, 2012. ,
Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro, Anticancer Res, vol.26, pp.3561-3567, 2006. ,
Acquisition of chemoresistance in a human ovarian carcinoma cell line is linked to a defect in cell cycle control, International Journal of Cancer, vol.381, issue.4, pp.454-63, 1998. ,
DOI : 10.1002/(SICI)1097-0215(19981109)78:4<454::AID-IJC11>3.0.CO;2-6
PI3K/mTOR dual inhibitor NVP-BEZ235 decreases Mcl-1 expression and sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies, provided that Bim expression is induced, Cancer Letters, vol.348, issue.1-2, 2014. ,
DOI : 10.1016/j.canlet.2014.03.001
Cancer of the Ovary, New England Journal of Medicine, vol.351, issue.24, pp.2519-2548, 2004. ,
DOI : 10.1056/NEJMra041842
??-Lipoic acid suppresses migration and invasion via downregulation of cell surface ??1-integrin expression in bladder cancer cells, Journal of Clinical Biochemistry and Nutrition, vol.54, issue.1, pp.18-25, 2014. ,
DOI : 10.3164/jcbn.13-57
??-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells, Nutrition Research, vol.30, issue.6, pp.403-412, 2010. ,
DOI : 10.1016/j.nutres.2010.06.009
Oncogenic BRAF signalling increases Mcl-1 expression in cutaneous metastatic melanoma, Experimental Dermatology, vol.387, issue.11, pp.767-776, 2013. ,
DOI : 10.1111/exd.12254
Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells, Molecular Cancer Therapeutics, vol.8, issue.11, pp.3162-70, 2009. ,
DOI : 10.1158/1535-7163.MCT-09-0493
BIM, PUMA, and the Achilles' Heel of Oncogene Addiction, Science Signaling, vol.6, issue.268, p.12, 2013. ,
DOI : 10.1126/scisignal.2004113
Bim Expression Is Reduced in Human Cutaneous Melanomas, Journal of Investigative Dermatology, vol.128, issue.2, pp.403-410, 2008. ,
DOI : 10.1038/sj.jid.5700989
Prognostic impact of the expression/phosphorylation of the BH3-only proteins of the BCL-2 family in glioblastoma multiforme, Cell Death and Disease, vol.80, issue.11, 2012. ,
DOI : 10.1056/NEJM200011093431901
Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family, Journal of Ovarian Research, vol.6, issue.1, pp.38-44, 2013. ,
DOI : 10.1016/j.ccr.2012.02.028
URL : https://hal.archives-ouvertes.fr/hal-00840946
NF-??B in Cancer: A Matter of Life and Death, Cancer Discovery, vol.1, issue.6, pp.469-71, 2011. ,
DOI : 10.1158/2159-8290.CD-11-0260
NF-kappaB activation fails to protect cells to TNFalpha-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w, Biochim Biophys Acta, vol.2013, pp.1085-95, 1833. ,
Lipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in C6 astrocyte cell line, International Journal of Developmental Neuroscience, vol.31, issue.3, pp.165-70, 2013. ,
DOI : 10.1016/j.ijdevneu.2012.12.006
ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim, Cell, vol.129, issue.7, pp.1337-1386, 2007. ,
DOI : 10.1016/j.cell.2007.04.027
Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L), Cell Death and Disease, vol.42, issue.2, 2014. ,
DOI : 10.1021/tx00026a012
Mitochondrial DNA Damage via Augmented Oxidative Stress Regulates Endoplasmic Reticulum Stress and Autophagy: Crosstalk, Links and Signaling, PLoS ONE, vol.105, issue.12, p.83349, 2013. ,
DOI : 10.1371/journal.pone.0083349.g004
Physiological Roles of Mitochondrial Reactive Oxygen Species, Molecular Cell, vol.48, issue.2, pp.158-67, 2012. ,
DOI : 10.1016/j.molcel.2012.09.025
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress, Cell Death and Differentiation, vol.14, issue.11, pp.1880-91, 2012. ,
DOI : 10.1016/j.bbamcr.2010.11.023
Ampelopsin Induces Cell Growth Inhibition and Apoptosis in Breast Cancer Cells through ROS Generation and Endoplasmic Reticulum Stress Pathway, PLoS ONE, vol.9, issue.2, p.89021, 2014. ,
DOI : 10.1371/journal.pone.0089021.g007
Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim, Biochemical and Biophysical Research Communications, vol.438, issue.3, pp.500-506, 2013. ,
DOI : 10.1016/j.bbrc.2013.07.107
Metabolic treatment of cancer: intermediate results of a prospective case series, Anticancer Res, vol.34, pp.973-80, 2014. ,