Skip to Main content Skip to Navigation
Journal articles

How to optimize the use of biobanks from population-based cohorts in aging research.

Abstract : In epidemiological cohorts, there is an increased interest for the implementation of biobanks. The potential role of biological determinants of diseases needs to be investigated before the onset of the event of interest in order to limit the problems encountered when examining biological determinants in classical case-control studies. Biobank is now a very sophisticated system that consists of a programmed storage of biological material and related data. Our aim in this paper is to document how biobank constitution is useful for studying biological determinants of aging and to give some indications on methodological issues that can be helpful to optimize the constitution and use of biobanks in aging cohorts. Optimization of sampling through two-phase designs (nested case control or case-cohort studies) allows better efficiency. These elements are, for most of them, not specific to aging populations but are useful more generally for the epidemiology of chronic diseases. Our purpose will be illustrated with some examples and results obtained in an ongoing aging cohort, the Three-City Study.
Document type :
Journal articles
Complete list of metadata

Cited literature [21 references]  Display  Hide  Download
Contributor : Claudine Berr Connect in order to contact the contributor
Submitted on : Friday, September 9, 2016 - 1:55:01 PM
Last modification on : Friday, September 9, 2022 - 10:20:08 AM
Long-term archiving on: : Saturday, December 10, 2016 - 12:35:07 PM


Berr Biogerontology 2016 Bioba...
Files produced by the author(s)



Claudine Berr, Audrey Gabelle, Nathalie Fievet, Marcel Goldberg, Marie Zins, et al.. How to optimize the use of biobanks from population-based cohorts in aging research.. Biogerontology, Springer Verlag, 2016, 17 (1), pp.221-7. ⟨10.1007/s10522-015-9586-8⟩. ⟨inserm-01180875⟩



Record views


Files downloads