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Therapy: Metformin takes a new route to clinical efficacy.

Abstract : Metformin is currently the first-line treatment option for patients with type 2 diabetes mellitus, yet its mechanism of action remains uncertain. A new study reveals the important role for the activation of a duodenal AMPK-dependent neuronal pathway in the acute antihyperglycaemic effect of metformin and the inhibition of hepatic glucose production.
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https://www.hal.inserm.fr/inserm-01171783
Contributor : Benoit Viollet <>
Submitted on : Monday, July 6, 2015 - 12:32:26 PM
Last modification on : Thursday, April 9, 2020 - 11:48:21 AM
Long-term archiving on: : Tuesday, April 25, 2017 - 11:56:28 PM

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Marc Foretz, Benoit Viollet. Therapy: Metformin takes a new route to clinical efficacy.. Nature Reviews Endocrinology, Nature Publishing Group, 2015, nature reviews endocrinology, 11 (7), pp.390-392. ⟨inserm-01171783⟩

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