Skip to Main content Skip to Navigation
Journal articles

Expanding roles for AMPK in skeletal muscle plasticity

Abstract : Skeletal muscle possesses a remarkable plasticity and responds to environmental and physiological challenges by changing its phenotype in terms of size, composition, and metabolic properties. Muscle fibers rapidly adapt to drastic changes in energy demands during exercise through fine-tuning of the balance between catabolic and anabolic processes. One major sensor of energy demand in exercising muscle is AMP-activated protein kinase (AMPK). Recent advances have shed new light on the relevance of AMPK both as a multitask gatekeeper and as an energy regulator in skeletal muscle. Here we summarize recent findings on the function of AMPK in skeletal muscle adaptation to contraction and highlight its role in the regulation of energy metabolism and the control of skeletal muscle regeneration post-injury.
Document type :
Journal articles
Complete list of metadatas

Cited literature [117 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01171734
Contributor : Benoit Viollet <>
Submitted on : Monday, July 6, 2015 - 11:27:43 AM
Last modification on : Thursday, April 9, 2020 - 11:56:13 AM
Long-term archiving on: : Tuesday, April 25, 2017 - 11:31:17 PM

Files

review_AMPK_muscle_Viollet_TEM...
Files produced by the author(s)

Identifiers

Citation

Rémi Mounier, Marine Théret, Louise Lantier, Marc Foretz, Benoit Viollet. Expanding roles for AMPK in skeletal muscle plasticity. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism , Elsevier, 2015, 26 (6), pp.275-286. ⟨10.1016/j.tem.2015.02.009⟩. ⟨inserm-01171734⟩

Share

Metrics

Record views

963

Files downloads

2237