The g277s mutation in transferrin does not disturb function, British Journal of Haematology, vol.32, issue.4, pp.674-675, 2003. ,
DOI : 10.1021/bi970628v
Paraquat and iron exposure as possible synergistic environmental risk factors in Parkinson???s disease, Neurotoxicity Research, vol.8, issue.2, pp.307-313, 2003. ,
DOI : 10.1007/BF03033150
Haploview: analysis and visualization of LD and haplotype maps, Bioinformatics, vol.21, issue.2, pp.263-265, 2005. ,
DOI : 10.1093/bioinformatics/bth457
MRI evaluation of brain iron in earlier- and later-onset Parkinson???s disease and normal subjects, Magnetic Resonance Imaging, vol.17, issue.2, pp.213-222, 1999. ,
DOI : 10.1016/S0730-725X(98)00155-6
Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography, Neurology, vol.45, issue.1, pp.182-184, 1995. ,
DOI : 10.1212/WNL.45.1.182
Intranigral Iron Injection Induces Behavioral and Biochemical "Parkinsonism" in Rats, Journal of Neurochemistry, vol.32, issue.6, pp.2133-2135, 1991. ,
DOI : 10.1007/BF01244786
Variants in TF and HFE Explain ???40% of Genetic Variation in Serum-Transferrin Levels, The American Journal of Human Genetics, vol.84, issue.1, pp.60-65, 2009. ,
DOI : 10.1016/j.ajhg.2008.11.011
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume, Nature Genetics, vol.41, issue.11, pp.1173-1175, 2009. ,
DOI : 10.1038/ng.209
Four variants in transferrin and HFE genes as potential markers of iron deficiency anaemia risk: an association study in menstruating women, Nutrition & Metabolism, vol.8, issue.1, p.69, 2011. ,
DOI : 10.1111/j.1365-2141.2009.07843.x
Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990, Neurology, vol.52, issue.6, pp.1214-1220, 1976. ,
DOI : 10.1212/WNL.52.6.1214
The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients, Neuroscience Letters, vol.327, issue.2, pp.91-94, 2002. ,
DOI : 10.1016/S0304-3940(02)00398-1
Parkinson's Disease and Residential Exposure to Maneb and Paraquat From Agricultural Applications in the Central Valley of California, American Journal of Epidemiology, vol.169, issue.8, pp.919-926, 2009. ,
DOI : 10.1093/aje/kwp006
Definition and Clinical Importance of Haplotypes, Annual Review of Medicine, vol.56, issue.1, pp.303-320, 2005. ,
DOI : 10.1146/annurev.med.56.082103.104540
High-Resolution Haplotype Structure in the Human Genome, Nature Genetics, vol.29, issue.2, pp.229-232, 2001. ,
DOI : 10.1038/ng1001-229
Human transferrin G277S mutation and iron deficiency in pregnancy, British Journal of Haematology, vol.96, issue.2, pp.249-250, 2006. ,
DOI : 10.1021/bi970628v
INCREASED NIGRAL IRON CONTENT IN POSTMORTEM PARKINSONIAN BRAIN, The Lancet, vol.330, issue.8569, pp.1219-1220, 1987. ,
DOI : 10.1016/S0140-6736(87)91361-4
Hepcidin and the Iron-Infection Axis, Science, vol.338, issue.6108, pp.768-772, 2012. ,
DOI : 10.1126/science.1224577
Interaction Between ABCB1 and Professional Exposure to Organochlorine Insecticides in Parkinson Disease, Archives of Neurology, vol.67, issue.6, pp.739-745, 2010. ,
DOI : 10.1001/archneurol.2010.101
CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease, Annals of Neurology, vol.158, issue.suppl 2, pp.430-434, 2004. ,
DOI : 10.1002/ana.20051
Professional exposure to pesticides and Parkinson disease, Annals of Neurology, vol.13, issue.suppl 2, pp.494-504, 2009. ,
DOI : 10.1002/ana.21717
Association study of the G258S transferrin gene polymorphism and Parkinson's disease in the Spanish population, Journal of Neurology, vol.64, issue.10, pp.1269-1270, 2005. ,
DOI : 10.1007/s00415-005-0695-1
I-Ferrotransferrin Binding Sites in the Mesencephalon of Control Subjects and Patients with Parkinson's Disease, Journal of Neurochemistry, vol.126, issue.6, pp.2338-2341, 1993. ,
DOI : 10.1002/ana.410320717
??-Synuclein expression is modulated at the translational level by iron, NeuroReport, vol.23, issue.9, pp.576-580, 2012. ,
DOI : 10.1097/WNR.0b013e328354a1f0
Neonatal iron potentiates adult MPTP-induced neurodegenerative and functional deficits, Parkinsonism & Related Disorders, vol.7, issue.2, pp.97-105, 2001. ,
DOI : 10.1016/S1353-8020(00)00028-6
Diagnostic Criteria for Parkinson Disease, Archives of Neurology, vol.56, issue.1, pp.33-39, 1999. ,
DOI : 10.1001/archneur.56.1.33
Potential sources of increased iron in the substantia nigra of parkinsonian patients, J Neural Transm, vol.70, pp.133-142, 2006. ,
DOI : 10.1007/978-3-211-45295-0_21
Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease, Neurology, vol.45, issue.6, pp.1138-1143, 1995. ,
DOI : 10.1212/WNL.45.6.1138
Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys, Free Radical Biology and Medicine, vol.35, issue.5, pp.540-547, 2003. ,
DOI : 10.1016/S0891-5849(03)00385-X
Mitochondrial Iron Metabolism and Its Role in Neurodegeneration, J Alzheimers Dis, vol.20, issue.2, pp.551-568, 2010. ,
Occurrence of depression and anxiety prior to Parkinson???s disease, Parkinsonism & Related Disorders, vol.16, issue.9, pp.576-581, 2010. ,
DOI : 10.1016/j.parkreldis.2010.06.014
The Effects of Polyphenols on Survival and Locomotor Activity in Drosophila melanogaster Exposed to Iron and Paraquat, Neurochemical Research, vol.27, issue.Suppl 1, pp.227-238, 2010. ,
DOI : 10.1007/s11064-009-0046-1
Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo, Neuron, vol.37, issue.6, pp.899-909, 2003. ,
DOI : 10.1016/S0896-6273(03)00126-0
Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age, Neurobiology of Aging, vol.28, issue.6, pp.907-913, 2007. ,
DOI : 10.1016/j.neurobiolaging.2006.04.003
Targeted Deletion of the Gene Encoding Iron Regulatory Protein-2 Causes Misregulation of Iron Metabolism and Neurodegenerative Disease in Mice, Nature Genetics, vol.27, issue.2, pp.209-214, 2001. ,
DOI : 10.1038/84859
Polymorphisms in the Transferrin 5??? Flanking Region Associated with Differences in Total Iron Binding Capacity: Possible Implications in Iron Homeostasis, Blood Cells, Molecules, and Diseases, vol.27, issue.2, pp.539-548, 2001. ,
DOI : 10.1006/bcmd.2001.0418
Role of dietary iron restriction in a mouse model of Parkinson's disease, Experimental Neurology, vol.190, issue.2, pp.506-514, 2004. ,
DOI : 10.1016/j.expneurol.2004.08.014
Regulation of the 75-kDa Subunit of Mitochondrial Complex I by Iron, Journal of Biological Chemistry, vol.276, issue.29, pp.27685-27692, 2001. ,
DOI : 10.1074/jbc.M100941200
The complete amino acid sequence of human serum transferrin., Proceedings of the National Academy of Sciences, vol.79, issue.8, pp.2504-2508, 1982. ,
DOI : 10.1073/pnas.79.8.2504
Midbrain iron content in early Parkinson disease: A potential biomarker of disease status, Neurology, vol.70, issue.Issue 16, Part 2, pp.1411-1417, 2008. ,
DOI : 10.1212/01.wnl.0000286384.31050.b5
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease, Neurobiology of Disease, vol.34, issue.3, pp.417-431, 2009. ,
DOI : 10.1016/j.nbd.2009.02.009
Genome-Wide Association Study Identifies Genetic Loci Associated with Iron Deficiency, PLoS ONE, vol.102, issue.3, pp.17390-21483845, 2011. ,
DOI : 10.1371/journal.pone.0017390.t002
Associations between Single Nucleotide Polymorphisms in Iron-Related Genes and Iron Status in Multiethnic Populations, PLoS ONE, vol.2, issue.6, pp.38339-22761678, 2012. ,
DOI : 10.1371/journal.pone.0038339.s003
Transcranial sonography for diagnosis of Parkinson's disease, BMC Neurology, vol.21, issue.10, 2010. ,
DOI : 10.1002/mds.21054
Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts, Movement Disorders, vol.3, issue.3, pp.334-340, 2007. ,
DOI : 10.1002/mds.21227
Expression of the neuronal transferrin receptor is age dependent and susceptible to iron deficiency, The Journal of Comparative Neurology, vol.64, issue.3, pp.420-430, 1998. ,
DOI : 10.1002/(SICI)1096-9861(19980831)398:3<420::AID-CNE8>3.0.CO;2-1
The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain, Journal of Neurochemistry, vol.28, issue.1, pp.233-245, 2004. ,
DOI : 10.1046/j.1471-4159.2003.02142.x
Iron trafficking inside the brain, Journal of Neurochemistry, vol.184, issue.5, pp.1730-1740, 2007. ,
DOI : 10.1016/j.brainres.2003.10.066
Iron Histochemistry of the Substantia Nigra in Parkinson's Disease, Neurodegeneration, vol.3, issue.4, pp.277-282, 1994. ,
Individual dopaminergic neurons show raised iron levels in Parkinson disease, Neurology, vol.68, issue.21, pp.1820-1825, 2007. ,
DOI : 10.1212/01.wnl.0000262033.01945.9a
Physiological and Pathological Role of Alpha-synuclein in Parkinson???s Disease Through Iron Mediated Oxidative Stress; The Role of a Putative Iron-responsive Element, International Journal of Molecular Sciences, vol.10, issue.3, pp.1226-1260, 2009. ,
DOI : 10.3390/ijms10031226
Iron Storage within Dopamine Neurovesicles Revealed by Chemical Nano-Imaging, PLoS ONE, vol.62, issue.9, pp.925-17895967, 2007. ,
DOI : 10.1371/journal.pone.0000925.g007
URL : https://hal.archives-ouvertes.fr/inserm-00383874
Ceruloplasmin Regulates Iron Levels in the Cns and Prevents Free Radical Injury, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.22, issue.15, pp.6578-6586, 2002. ,
Iron and Paraquat as Synergistic Environmental Risk Factors in Sporadic Parkinson's Disease Accelerate Age-Related Neurodegeneration, Journal of Neuroscience, vol.27, issue.26, pp.6914-6922, 2007. ,
DOI : 10.1523/JNEUROSCI.1569-07.2007
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses, The American Journal of Human Genetics, vol.81, issue.3, pp.559-575, 2007. ,
DOI : 10.1086/519795
Genetics of iron regulation and the possible role of iron in Parkinson's disease, Neurobiology of Disease, vol.32, issue.2, pp.183-195, 2008. ,
DOI : 10.1016/j.nbd.2008.07.001
??-Synuclein Genetic Variants Predict Faster Motor Symptom Progression in Idiopathic Parkinson Disease, PLoS ONE, vol.75, issue.5, pp.36199-22615757, 2012. ,
DOI : 10.1371/journal.pone.0036199.t007
Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins, Metabolic Brain Disease, vol.192, issue.4, pp.673-684, 2009. ,
DOI : 10.1007/s11011-009-9169-y
The G277S transferrin mutation does not affect iron absorption in iron deficient women, European Journal of Nutrition, vol.51, issue.3, pp.57-60, 2007. ,
DOI : 10.1007/s00394-006-0631-x
Score Tests for Association between Traits and Haplotypes when Linkage Phase Is Ambiguous, The American Journal of Human Genetics, vol.70, issue.2, pp.425-434, 2002. ,
DOI : 10.1086/338688
Infusion of iron into the rat substantia nigra: Nigral pathology and dose-dependent loss of striatal dopaminergic markers, Journal of Neuroscience Research, vol.10, issue.1, pp.67-82, 1993. ,
DOI : 10.1002/jnr.490350109
Haplo Stats (version 1.5.0): Statistical Methods for Haplotypes When Linkage Phase is Ambiguous, p.10026895, 2013. ,
Iron, the substantia nigra and related neurological disorders, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1790, issue.7, pp.606-614, 2009. ,
DOI : 10.1016/j.bbagen.2008.08.005
Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains, Journal of Neurochemistry, vol.53, issue.3, pp.978-982, 1991. ,
DOI : 10.1007/BF00964867
Do Polymorphisms in the Familial Parkinsonism Genes Contribute to Risk for Sporadic Parkinson's Disease? Movement disorders : official journal of the, pp.833-838, 2009. ,
Manganese: A transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of Parkinsonism, Neuroscience, vol.85, issue.4, pp.1101-1111, 1998. ,
DOI : 10.1016/S0306-4522(97)00660-X
A genome-wide association analysis of serum iron concentrations, Blood, vol.115, issue.1, pp.94-96, 2010. ,
DOI : 10.1182/blood-2009-07-232496
Oligodendrocytes and myelination: The role of iron, Glia, vol.18, issue.5 Part 2, pp.467-478, 2009. ,
DOI : 10.1002/glia.20784
Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations, Journal of Medical Genetics, vol.48, issue.9, pp.629-634, 2011. ,
DOI : 10.1136/jmedgenet-2011-100061
Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human ??-Synuclein: A POSSIBLE MOLECULAR LINK BETWEEN PARKINSON'S DISEASE AND HEAVY METAL EXPOSURE, Journal of Biological Chemistry, vol.276, issue.47, pp.44284-44296, 2001. ,
DOI : 10.1074/jbc.M105343200
Gene???environment interactions in Parkinson's disease and other forms of parkinsonism, NeuroToxicology, vol.31, issue.5, pp.598-602, 2010. ,
DOI : 10.1016/j.neuro.2010.04.007
Assessing the Performance of the Haplotype Block Model of Linkage Disequilibrium, The American Journal of Human Genetics, vol.73, issue.3, pp.502-515, 2003. ,
DOI : 10.1086/378099
Substantia Nigra Echogenicity Is Normal in Non- Extrapyramidal Cerebral Disorders but Increased in Parkinson's Disease, Journal of Neural Transmission, vol.109, issue.2, pp.191-196, 2002. ,
DOI : 10.1007/s007020200015
Intranigral injected iron progressively reduces striatal dopamine metabolism, Journal of Neural Transmission - Parkinson's Disease and Dementia Section, vol.17, issue.3, pp.209-214, 1994. ,
DOI : 10.1007/BF02260941
Effects of HFE C282Y and H63D Polymorphisms and Polygenic Background on Iron Stores in a Large Community Sample of Twins, The American Journal of Human Genetics, vol.66, issue.4, pp.1246-1258, 2000. ,
DOI : 10.1086/302862
Iron, brain ageing and neurodegenerative disorders, Nature Reviews Neuroscience, vol.41, issue.11, pp.863-873, 2004. ,
DOI : 10.1016/S0006-2952(99)00079-9
Neuroprotection by Iron Chelator against Proteasome Inhibitor-Induced Nigral Degeneration. Biochemical and biophysical research communications, pp.544-549, 2005. ,