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Co-activation of AMPK and mTORC1 Induce Cytotoxicity in Acute Myeloid Leukemia

Abstract : Graphical Abstract Highlights d AMPK activation blocks AML propagation without toxicity to normal hematopoiesis d Cytotoxicity induced by an AMPK activator (GSK621) involves autophagy in AML d Co-activation of AMPK and mTORC1 is synthetically lethal in AML d AMPK and mTORC1 crosstalk requires eIF2a/ATF4 signaling
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https://www.hal.inserm.fr/inserm-01158968
Contributor : Mireille Bos <>
Submitted on : Tuesday, June 2, 2015 - 11:35:03 AM
Last modification on : Monday, May 18, 2020 - 11:00:35 AM
Long-term archiving on: : Monday, April 24, 2017 - 11:21:55 PM

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Pierre Sujobert, Laury Poulain, Etienne Paubelle, Florence Zylbersztejn, Adrien Grenier, et al.. Co-activation of AMPK and mTORC1 Induce Cytotoxicity in Acute Myeloid Leukemia. Cell Reports, Elsevier Inc, 2015, Epub ahead of print. ⟨10.1016/j.celrep.2015.04.063⟩. ⟨inserm-01158968⟩

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