Skip to Main content Skip to Navigation
Journal articles

APOE polymorphism, socioeconomic status and cognitive function in mid-life--the Whitehall II longitudinal study.

Abstract : The aim of this study was to investigate the association of the common apolipoprotein E gene (APOE) variants with cognitive function and cognitive decline in adult mid-life and explore the possibility that APOE genotype mediates the link between socioeconomic status (SES) and cognitive function. Data on cognitive function, as measured by five cognitive tests, together with APOE genotype were obtained in an occupational cohort (the Whitehall II study) of 6,004 participants aged 44-69 years (1997-1999). Cognitive change was examined in 2,717 participants who had cognitive function measured at baseline (1991-1993). SES based on civil service employment grade was strongly related to cognitive function. There was no association between APOE genotype and employment grade. In women, participants with APOE-epsilon4 had a lower memory score (p<0.05), but the result was sensitive to data from a small number of individuals. A marginal cross-sectional difference in the semantic fluency score was found (p=0.07), and there was a relative decline at follow-up (p<0.001, net change=-1.19; 95% CI, -1.90 to -0.49) in those with APOE-epsilon4 genotypes. APOE-epsilon4 has little influence on cognitive decline in mid-life, whereas SES is a strong determinant, although APOE genotype may emerge as an important factor in cognitive function in later life.
Document type :
Journal articles
Complete list of metadatas

Cited literature [40 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01155229
Contributor : Pascale Sztajnbok <>
Submitted on : Tuesday, May 26, 2015 - 12:15:18 PM
Last modification on : Saturday, May 30, 2015 - 1:02:45 AM
Long-term archiving on: : Tuesday, September 15, 2015 - 6:53:18 AM

File

Zhao et al. APOE SPPE 2005.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Jing Hua Zhao, Eric Brunner, Meena Kumari, Archana Singh-Manoux, Emma Hawe, et al.. APOE polymorphism, socioeconomic status and cognitive function in mid-life--the Whitehall II longitudinal study.. Social Psychiatry and Psychiatric Epidemiology, Springer Verlag, 2005, 40 (7), pp.557-63. ⟨10.1007/s00127-005-0925-y⟩. ⟨inserm-01155229⟩

Share

Metrics

Record views

334

Files downloads

108