Utility of Elastography and Contrast-enhanced Ultrasound For The Differentiation of
Tumor Modifications Between Antiangiogenic and Cytotoxic Therapy

Alexandre Dizeux; Thomas Payen; Guillaume Barrois; Capucine Baldini; Michele Lamuraglia; Delphine Le Guillou Buffello; Eva Comperat; Jean-Luc Gennisson; Mickael Tanter; S. Lori Bridal

Utility of Elastography and Contrast-enhanced Ultrasound For The Differentiation of Tumor Modifications Between Antiangiogenic and Cytotoxic Therapy

Alexandre Dizeux ¹ Thomas Payen ¹ Guillaume Barrois ¹ Capucine Baldini ¹ Michele Lamuraglia ^{1, 2} Delphine Le Guillou Buffello ¹ Eva Comperat ² Jean-Luc Gennisson ³ Mickael Tanter ³ S. Lori Bridal ¹

1 LIB - Laboratoire d'Imagerie Biomédicale

2 Service d’Oncologie

3 POM - Physique des Ondes pour la Médecine et la Biologie

INSERM - Institut National de la Santé et de la Recherche Médicale : U979, Institut Langevin ondes et images

Abstract : Robust, novel information on tumor microenvironment would improve therapeutic follow-up in oncology. Shear wave elastography (SWE) evaluates Young's modulus (stiffness) based on shear wave velocity. Dynamic contrast-enhanced ultrasound (CEUS) traces microvascular flow with intravascular microbubbles. In this study, an ectopic tumor model was modified using two different types of drugs a cytotoxic (cyclophosphamide) and an anti-angiogenic (sunitinib). Both CEUS and SWE imaging were sensitive to functional, physiological and mechanical modifications of the tumor and provided complementarity information to describe these modifications.

Keywords : Shear Wave Elastography Contrast-Enhanced Ultrasound Tumor microenvironment Therapy monitoring

Document type :

Conference papers

Domain :

Life Sciences [q-bio] / Bioengineering

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https://www.hal.inserm.fr/inserm-01155177
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Submitted on : Tuesday, May 26, 2015 - 11:40:36 AM
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