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Utility of Elastography and Contrast-enhanced Ultrasound For The Differentiation of Tumor Modifications Between Antiangiogenic and Cytotoxic Therapy

Alexandre Dizeux 1 Thomas Payen 1 Guillaume Barrois 1 Capucine Baldini 1 Michele Lamuraglia 1, 2 Delphine Le Guillou Buffello 1 Eva Comperat 2 Jean-Luc Gennisson 3, 4 Mickael Tanter 3, 4 S. Lori Bridal 1
1 LIB - Laboratoire d'Imagerie Biomédicale
2 Service d’Oncologie
3 Physique des ondes pour la médecine
ESPCI Paris - Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, INSERM - Institut National de la Santé et de la Recherche Médicale : U979, CNRS - Centre National de la Recherche Scientifique : UMR7587
4 IL - Institut Langevin - Ondes et Images (UMR7587)
Abstract : Robust, novel information on tumor microenvironment would improve therapeutic follow-up in oncology. Shear wave elastography (SWE) evaluates Young's modulus (stiffness) based on shear wave velocity. Dynamic contrast-enhanced ultrasound (CEUS) traces microvascular flow with intravascular microbubbles. In this study, an ectopic tumor model was modified using two different types of drugs a cytotoxic (cyclophosphamide) and an anti-angiogenic (sunitinib). Both CEUS and SWE imaging were sensitive to functional, physiological and mechanical modifications of the tumor and provided complementarity information to describe these modifications.
Keywords : Shear Wave Elastography Contrast-Enhanced Ultrasound Tumor microenvironment Therapy monitoring
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https://www.hal.inserm.fr/inserm-01155177
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Submitted on : Tuesday, May 26, 2015 - 11:40:36 AM
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Alexandre Dizeux, Thomas Payen, Guillaume Barrois, Capucine Baldini, Michele Lamuraglia, et al.. Utility of Elastography and Contrast-enhanced Ultrasound For The Differentiation of Tumor Modifications Between Antiangiogenic and Cytotoxic Therapy. Journées RITS 2015, May 2015, Dourdan, France. ⟨inserm-01155177⟩

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