Utility of Elastography and Contrast-enhanced Ultrasound For The Differentiation of Tumor Modifications Between Antiangiogenic and Cytotoxic Therapy

Abstract : Robust, novel information on tumor microenvironment would improve therapeutic follow-up in oncology. Shear wave elastography (SWE) evaluates Young's modulus (stiffness) based on shear wave velocity. Dynamic contrast-enhanced ultrasound (CEUS) traces microvascular flow with intravascular microbubbles. In this study, an ectopic tumor model was modified using two different types of drugs a cytotoxic (cyclophosphamide) and an anti-angiogenic (sunitinib). Both CEUS and SWE imaging were sensitive to functional, physiological and mechanical modifications of the tumor and provided complementarity information to describe these modifications.
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https://www.hal.inserm.fr/inserm-01155177
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Alexandre Dizeux, Thomas Payen, Guillaume Barrois, Capucine Baldini, Michele Lamuraglia, et al.. Utility of Elastography and Contrast-enhanced Ultrasound For The Differentiation of Tumor Modifications Between Antiangiogenic and Cytotoxic Therapy. Journées RITS 2015, May 2015, Dourdan, France. ⟨inserm-01155177⟩

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