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Development of Targeted Microbubbles for Ultrasound Molecular Imaging of Breast Cancer

Abstract : A subtype of metastatic breast cancer has recently been identified, in which netrin-1 is over-expressed. Netrin-1 binds to dependence receptors inducing survival, while its absence actively triggers apoptosis. An anti-netrin-1 therapy is under development , which disrupts ligand-receptor interaction and induces apoptosis. To identify potential responders for such a targeted therapy, netrin-1 expression has to be analyzed. Molecular imaging with ultrasound (US) is able to detect the expression of a specific protein when using targeted contrast agents. Thus, we aim to develop an US molecular imaging approach using microbubbles (MB) functionalized with an anti-netrin-1 antibody. Binding was tested on purified netrin-1 protein in static and dynamic conditions. Anti-netrin-1 MB were validated in in-vitro assays and will be further tested in pre-clinical studies using metastatic breast cancer animal models.
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https://www.hal.inserm.fr/inserm-01155018
Contributor : Frédérique Frouin <>
Submitted on : Tuesday, May 26, 2015 - 7:39:34 AM
Last modification on : Wednesday, June 10, 2020 - 6:42:06 PM
Long-term archiving on: : Thursday, April 20, 2017 - 8:11:51 AM

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Jennifer Wischhusen, Jean-Guy Delcros, Patrick Mehlen, Frédéric Padilla. Development of Targeted Microbubbles for Ultrasound Molecular Imaging of Breast Cancer. Journées RITS 2015, Mar 2015, Dourdan, France. pp 150-151. ⟨inserm-01155018⟩

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