Diffuse optical tomography (DOT) is a growing area of research in the field of biomedical optics and neurosciences. Over the past 20 years, technical development allowed a more and more accurate detection of the brain activation. In order to increase the accuracy of the brain’s activation detection, we have developed a Hyperspectral Time Resolved DOT system. It is composed of a compact supercontinuum laser within the picosecond range for the source part and of an ICCD camera coupled with an imaging spectrometer for the detection part. This allows a simultaneous detection of the spatial, time resolved, and spectral information. Through the information acquired by our system, we can propose a method that increases the accuracy of the optical imaging of the cerebral activity, both spatially and in term of specificity, by obtaining its broadband optical characterization. On top of the improvement of the accuracy of the detection, the compact size of our system has the great potential to be easily transport in a clinical environment.