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EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries.

John Danesh 1 Rodolfo Saracci 2 Göran Berglund 3 Edith Feskens 4 Kim Overvad 5 Salvatore Panico 6 Simon Thompson 7 Agnès Fournier 8 Françoise Clavel-Chapelon 8 Marianne Canonico 9 Rudolf Kaaks 10 Jakob Linseisen 10 Heiner Boeing 11 Tobias Pischon 11 Cornelia Weikert 11 Anja Olsen 12 Anne Tjønneland 12 Søren Paaske Johnsen 13 Majken Karoline Jensen 5 Jose R Quirós 14 Carlos Alberto Gonzalez Svatetz 15 Maria-José Sánchez Pérez 16 Nerea Larrañaga 17 Carmen Navarro Sanchez 18 Concepción Moreno Iribas 19 Sheila Bingham 20 Kay-Tee Khaw 21 Nick Wareham 22 Timothy Key 23 Andrew Roddam 24 Antonia Trichopoulou 25 Vassiliki Benetou 26 Dimitrios Trichopoulos 25 Giovanna Masala 27 Sabina Sieri 28 Rosario Tumino 29 Carlotta Sacerdote 30 Amalia Mattiello 31 W M Monique Verschuren 32 H Bas Bueno-De-Mesquita 32 Diederick E Grobbee 33 Yvonne T van Der Schouw 34 Olle Melander 3 Göran Hallmans Patrik Wennberg 35 Eiliv Lund Merethe Kumle 36 Guri Skeie Pietro Ferrari 37 Nadia Slimani 38 Teresa Norat 39 Elio Riboli 40 
7 Plasmon Nano-optics
ICFO - Institut de Ciencies Fotoniques [Castelldefels]
Abstract : EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition (EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle (especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants (366,521 women and 153,457 men, mostly aged 35-70 years) in 23 centres in 10 European countries commenced follow-up for cause- specific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors.
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  • HAL Id : inserm-01149104, version 1
  • PUBMED : 17295097


John Danesh, Rodolfo Saracci, Göran Berglund, Edith Feskens, Kim Overvad, et al.. EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries.. European Journal of Epidemiology, Springer Verlag, 2006, 22 (2), pp.129-41. ⟨inserm-01149104⟩



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