Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Validating a widely used measure of frailty: are all sub-components necessary? Evidence from the Whitehall II cohort study.

Abstract : There is growing interest in the measurement of frailty in older age. The most widely used measure (Fried) characterizes this syndrome using five components: exhaustion, physical activity, walking speed, grip strength, and weight loss. These components overlap, raising the possibility of using fewer, and therefore making the device more time- and cost-efficient. The analytic sample was 5,169 individuals (1,419 women) from the British Whitehall II cohort study, aged 55 to 79 years in 2007-2009. Hospitalization data were accessed through English national records (mean follow-up 15.2 months). Age- and sex-adjusted Cox models showed that all components were significantly associated with hospitalization, the hazard ratios (HR) ranging from 1.18 (95 % confidence interval = 0.98, 1.41) for grip strength to 1.60 (1.35, 1.90) for usual walking speed. Some attenuation of these effects was apparent following mutual adjustment for frailty components, but the rank order of the strength of association remained unchanged. We observed a dose-response relationship between the number of frailty components and the risk for hospitalization [1 component-HR = 1.10 (0.96, 1.26); 2-HR = 1.52 (1.26, 1.83); 3-5-HR = 2.41 (1.84, 3.16), P trend <0.0001]. A concordance index used to evaluate the predictive power for hospital admissions of individual components and the full scale was modest in magnitude (range 0.57 to 0.58). Our results support the validity of the multi-component frailty measure, but the predictive performance of the measure is poor.
Document type :
Journal articles
Complete list of metadata

Cited literature [36 references]  Display  Hide  Download
Contributor : Pascale SZTAJNBOK Connect in order to contact the contributor
Submitted on : Thursday, April 30, 2015 - 10:04:46 AM
Last modification on : Sunday, June 26, 2022 - 12:03:23 PM
Long-term archiving on: : Wednesday, April 19, 2017 - 10:51:19 AM


Publication funded by an institution




Kim Bouillon, Severine Sabia, Markus Jokela, Catharine R Gale, Archana Singh-Manoux, et al.. Validating a widely used measure of frailty: are all sub-components necessary? Evidence from the Whitehall II cohort study.. AGE, Springer Verlag, 2013, 35 (4), pp.1457-65. ⟨10.1007/s11357-012-9446-2⟩. ⟨inserm-01147297⟩



Record views


Files downloads