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Development and validation of a motorized focused ultrasound system for the controlled delivery of large molecules to the rodent brain under 7T MRI guidance

Remi Magnin 1, * Sébastien Mériaux 1 Denis Le Bihan 1 Erik Dumont 2 Benoît Larrat 1
* Corresponding author
1 Unité d'imagerie par IRM et de Spectroscopie
NEUROSPIN - Service NEUROSPIN, CEA/DSV/I2BM
Abstract : The use of focused ultrasound combined with microbubbles has shown the capability to increase the permeability of the Blood Brain Barrier (BBB) locally, transiently and non-invasively, allowing the delivery of large molecules to the brain. Magnetic Resonance Imaging is of great interest to precisely monitor the disruption. In this study, we have shown the possibility to use our motorized system to open the BBB along arbitrary trajectories under 7T MRI guidance and to test different acoustic conditions on a single animal.
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Conference papers
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https://www.hal.inserm.fr/inserm-01145628
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Submitted on : Friday, April 24, 2015 - 5:55:33 PM
Last modification on : Monday, February 10, 2020 - 6:14:06 PM
Long-term archiving on: : Wednesday, April 19, 2017 - 6:04:41 AM

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  • HAL Id : inserm-01145628, version 1

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Remi Magnin, Sébastien Mériaux, Denis Le Bihan, Erik Dumont, Benoît Larrat. Development and validation of a motorized focused ultrasound system for the controlled delivery of large molecules to the rodent brain under 7T MRI guidance. Journées RITS 2015, Mar 2015, Dourdan, France. p72-73 Section imagerie et thérapie par ultrasons. ⟨inserm-01145628⟩

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