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Conference papers
Evaluation of Eventual Risks of Unseeded Inertial Cavitation for Enhancing the Delivery of Chemotherapies
Abstract : Acoustic cavitation is widely used to improve drug delivery in tumors. In this study, we evaluate the safety of using unseeded inertial cavitation (without external nucleation agents) for this application. We show that unseeded inertial cavitation (UIC) does not degrade doxorubicin molecules or alter its cytotoxicity. Moreover, histopathologic analysis shows only slight or reversible moderate effects on healthy tissues. Finally, UIC does not promote metastatic spreading. Thus, the particular conditions used in this study provide the possibility of safe UIC concerning these three points.
Cited literature [6 references]
https://www.hal.inserm.fr/inserm-01145626
Contributor : Nathalie Duchange Connect in order to contact the contributor
Submitted on : Friday, April 24, 2015 - 5:45:53 PM
Last modification on : Tuesday, October 19, 2021 - 11:07:41 PM
Long-term archiving on: : Wednesday, April 19, 2017 - 6:00:14 AM
Contributor : Nathalie Duchange Connect in order to contact the contributor
Submitted on : Friday, April 24, 2015 - 5:45:53 PM
Last modification on : Tuesday, October 19, 2021 - 11:07:41 PM
Long-term archiving on: : Wednesday, April 19, 2017 - 6:00:14 AM
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ACTES-RITS2015-HAL-p70-71.pdf
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Distributed under a Creative Commons Attribution 4.0 International License