Abstract : Acoustic cavitation is widely used to improve drug delivery in tumors. In this study, we evaluate the safety of using unseeded inertial cavitation (without external nucleation agents) for this application. We show that unseeded inertial cavitation (UIC) does not degrade doxorubicin molecules or alter its cytotoxicity. Moreover, histopathologic analysis shows only slight or reversible moderate effects on healthy tissues. Finally, UIC does not promote metastatic spreading. Thus, the particular conditions used in this study provide the possibility of safe UIC concerning these three points.
http://www.hal.inserm.fr/inserm-01145626
Contributeur : Nathalie Duchange
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Soumis le : vendredi 24 avril 2015 - 17:45:53
Dernière modification le : mardi 12 juin 2018 - 11:29:25
Document(s) archivé(s) le : mercredi 19 avril 2017 - 06:00:14
Maxime Lafond, Jean-Louis Mestas, Fabrice Prieur, Kamel Chettab, Philippe Clézardin, et al.. Evaluation of Eventual Risks of Unseeded Inertial Cavitation for Enhancing the Delivery of Chemotherapies. Journées RITS 2015, Mar 2015, Dourdan, France. Actes des Journées RITS 2015, p70-71 Section imagerie et thérapie par ultrasons, 2015. 〈inserm-01145626〉
