Phosphonate PEG Copolymers to control the USPIO stealthiness

Abstract : For nanomedicine applications, there is a need to design advanced and cost-effective coatings, resistant to protein adsorption leading to increased biodistribution in vivo. In this study, phosphonate poly(ethylene glycol) copolymers were synthesized and used to coat 6nm and 13nm iron oxide particle. In vitro, PEGylated particles exhibit exceptional stability and low cellular uptake, of the order of 100 femtograms of iron per cell. In vivo, we developed an in vivo Dynamic Susceptibility Weighted MRI (7T) protocol to monitor the hepatic capture and clearance of the particles injected to mice as a function of the time. PEGylated coat of molecular weight 2000 gmol-1 show a 2hrs delay to liver uptake as compared to the commercially available USPIO Cliavist, indicating a direct correlation between the surface properties of the contrast agents and their stealthiness.
Document type :
Conference papers
Complete list of metadatas

Cited literature [4 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01145542
Contributor : Nathalie Duchange <>
Submitted on : Friday, April 24, 2015 - 3:12:29 PM
Last modification on : Monday, May 27, 2019 - 6:24:02 PM
Long-term archiving on : Wednesday, April 19, 2017 - 4:58:17 AM

File

ACTES-RITS2015-HAL-p20-21.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

  • HAL Id : inserm-01145542, version 1

Citation

Gregory Ramniceanu, Bich-Thuy Doan, Camille Vezignol, Alain Graillot, Quentin Crouzet, et al.. Phosphonate PEG Copolymers to control the USPIO stealthiness. Journées RITS 2015, Mar 2015, Dourdan, France. p20-21. ⟨inserm-01145542⟩

Share

Metrics

Record views

410

Files downloads

154