Prospects of apoptotic cell-based therapies for transplantation and inflammatory diseases.

Philippe Saas 1, 2, 3, 4 Sandra Kaminski 1, 2, 3, 4 Sylvain Perruche 1, 2, 3, 4
1 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
2 LabEx LipSTIC - Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer
3 UFC - Université de Franche-Comté
4 EFS-BFC - EFS Bourgogne Franche-Comté
Abstract : Apoptotic cell removal or interactions of early-stage apoptotic cells with immune cells are associated with an immunomodulatory microenvironment that can be harnessed to exert therapeutic effects. While the involved immune mechanisms are still being deciphered, apoptotic cell infusion has been tested in different experimental models where inflammation is deregulated. This includes chronic and acute inflammatory disorders such as arthritis, contact hypersensitivity and acute myocardial infarction. Apoptotic cell infusion has also been used in transplantation settings to prevent or treat acute and chronic rejection, as well as to limit acute graft-versus-host disease associated with allogeneic hematopoietic cell transplantation. Here, we review the mechanisms involved in apoptotic cell-induced immunomodulation and data obtained in preclinical models of transplantation and inflammatory diseases.
Keywords : cell therapy regulatory T cells dendritic cells macrophages transplantation inflammation apoptotic cells immunotherapy tolerance arthritis
Type de document :
Article dans une revue
Cancer Immunology, Immunotherapy, Springer Verlag, 2013, 5 (10), pp.1055-73. 〈10.2217/imt.13.103〉
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Contributeur : Philippe Saas <>
Soumis le : mardi 21 avril 2015 - 10:23:01
Dernière modification le : lundi 9 juillet 2018 - 13:12:02
Document(s) archivé(s) le : lundi 14 septembre 2015 - 11:11:01

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Philippe Saas, Sandra Kaminski, Sylvain Perruche. Prospects of apoptotic cell-based therapies for transplantation and inflammatory diseases.. Cancer Immunology, Immunotherapy, Springer Verlag, 2013, 5 (10), pp.1055-73. 〈10.2217/imt.13.103〉. 〈inserm-01144117〉

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